3O4X: Protein diaphanous homolog 1

Crystal structure of complex between amino and carboxy terminal fragments of mDia1. Determined by X-ray diffraction at 3.2 Å resolution. Released 13 Oct 2010.

Method

X-ray diffraction

Resolution

3.2 Å

Organism

Mus musculus

Chains

8

Atoms

24,335

Mol. weight

367.47 kDa

Released

13 Oct 2010

Explore 3O4X in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3O4X contains 161 α-helices and 30 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 16 helices, 1 β-strand

Molecules and chains

>3O4X_1 Protein diaphanous homolog 1 (chains A, B, C, D)
GSESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKR
LHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI
DAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLDGLKSGTSIALKVGCLQL
INALITPAEELDFRVHIRSELMRLGLHQVLQELREIENEDMKVQLCVFDEQGDEDFFDLK
GRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEEC
VSQIVLHKNGTDPDFKCRHLQIDIERLVDQ

>3O4X_2 Protein diaphanous homolog 1 (chains E, F, G, H)
GSFGFGVPAAPVLPFGLTPKKVYKPEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNE
LFAKLTLAFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMP
YQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKEEYDDLAESEQFGVVMGTV
PRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAG
SRNAGAFGFNISFLCKLRDTKSADQKMTLLHFLAELCENDHPEVLKFPDELAHVEKASRV
SAENLQKSLDQMKKQIADVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSN
METLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKE
KAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRG

Primary citation

Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins. Nezami, A., Poy, F., Toms, A. et al. PLoS One (2010) 5:e12992-e12992. DOI 10.1371/journal.pone.0012992 · PubMed

Related structures

Other PDB entries of the same protein (UniProt O08808 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 2V8F 1.1 Å, Mouse Profilin IIa in complex with a double repeat from the FH1 domain of mDia1
• 4UWX 1.65 Å, Structure of liprin-alpha3 in complex with mDia1 Diaphanous- inhibitory domain
• 2F31 2.1 Å, Crystal structure of the autoinhibitory switch in Formin mDia1; the DID/DAD complex
• 2BNX 2.4 Å, Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin…
• 1V9D 2.6 Å, Crystal structure of the core FH2 domain of mouse mDia1
• 3EG5 2.7 Å, Crystal structure of MDIA1-TSH GBD-FH3 in complex with CDC42-GMPPNP
• 3OBV 2.75 Å, Autoinhibited Formin mDia1 Structure
• 1Z2C 3.0 Å, Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
• 2BAP 3.3 Å, Crystal structure of the N-terminal mDia1 Armadillo Repeat Region and Dimerisation…
• 9B3D 3.41 Å, mDia1 in the middle of F-actin
• 8RU2 3.49 Å, Structure of the F-actin barbed end bound by formin mDia1
• 9B27 3.51 Å, Dia1 at the Barbed End of F-Actin

Browse structure collections

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