3PVL: Myosin VIIa MyTH4-FERM-SH3

Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans. Determined by X-ray diffraction at 2.8 Å resolution. Released 2 Mar 2011.

Method
X-ray diffraction
Resolution
2.8 Å
Organisms
Mus musculus, Homo sapiens
Chains
2
Atoms
4,997
Mol. weight
85.59 kDa
Ligands
PO4
Released
2 Mar 2011

Explore 3PVL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3PVL contains 36 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 36 helices, 22 β-strands

ElementResiduesLengthSheet
α-helix1001-10088
β-strand100911
α-helix1021-10222
β-strand102711
α-helix1032-104918
α-helix1053-10564
α-helix1070-10756
α-helix1084-10885
α-helix1150-116314
α-helix1165-11673
α-helix1168-117811
α-helix1185-120117
α-helix1203-12053
α-helix1209-12179
α-helix1224-123714
α-helix1243-12453
α-helix1246-12549
α-helix1256-12572
β-strand1258-126472
β-strand1269-127462
β-strand127913
α-helix1280-129011
β-strand1299-130572
β-strand1308-131362
β-strand131813
α-helix1319-133113
α-helix1337-13393
β-strand1343-134862
α-helix1357-13593
α-helix1361-137717
α-helix1385-140016
α-helix1406-141611
α-helix1419-14213
α-helix1428-144417
α-helix1451-146515
β-strand1472-148094
β-strand1488-149474
β-strand1497-150154
β-strand1507-151264
α-helix1513-15153
β-strand1516-152274
α-helix1529-15302
β-strand1531-153664
β-strand1541-154554
α-helix1549-156618
β-strand1569-157245
α-helix1575-15773
β-strand158615
α-helix1587-15882
β-strand1594-159745
α-helix1602-16076
β-strand1610-161565
β-strand1621-162555
α-helix1626-16283
β-strand1629-163135
α-helix16321
α-helix1637-16393
α-helix1640-16467
Chain B: 0 helices, 2 β-strands
ElementResiduesLengthSheet
β-strand308-30922
β-strand313-31532

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Myosin VIIa isoform 1Aprotein655Mus musculusP97479 (AlphaFold model)
Usher syndrome type-1G proteinBprotein96Homo sapiensQ495M9 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>3PVL_1 Myosin VIIa isoform 1 (chains A)
SGFEDLERGRREMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQ
PLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYK
RELQALQGEGEVTKRLNDGESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQ
ISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEERLRRT
FVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTARELCNALADKISLK
DRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPW
HNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLSLVP
TYIPDREITPLKNLEKWAQLAIAAHKKGIYAQRRTDSQKVKEDVVNYARFKWPLLFSRFY
EAYKFSGPPLPKSDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRGTKMMAPSFTL
ATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSFAKGDL
IILDHDTGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVTMT
Sequence of entity 2 (B), FASTA
>3PVL_2 Usher syndrome type-1G protein (chains B)
SEVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDGGLDGVGAPRGRLQSSPSLDD
DSLGSANSLQDRSCGEELPWDELDLGLDEDLEPETS

Ligands and cofactors

IDNameFormulaCopies
PO4Phosphate ionO4 P2

Water and common crystallization additives (GOL) are not listed.

Primary citation

Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Wu, L., Pan, L., Wei, Z. et al. Science (2011) 331:757-760. DOI 10.1126/science.1198848 · PubMed

Other PDB entries of the same protein (UniProt P97479 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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