5WSV: Myosin VIIa IQ5

Crystal structure of Myosin VIIa IQ5 in complex with Ca2+-CaM. Determined by X-ray diffraction at 2.33 Å resolution. Released 7 Jun 2017.

Method: X-ray diffraction
Resolution: 2.33 Å
Organisms: Homo sapiens, Mus musculus
Chains: 4
Atoms: 2,507
Mol. weight: 45.83 kDa
Ligands: CA
Released: 7 Jun 2017

Explore 5WSV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5WSV contains 18 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	1
α-helix	65-72	8
α-helix	82-92	11
β-strand	100	1	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-143	6

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	828-853	26

Chain C: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	3
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	3
α-helix	65-72	8
α-helix	82-92	11
β-strand	100	1	4
α-helix	102-111	10
α-helix	118-128	11
β-strand	136	1	4
α-helix	138-145	8

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	829-855	27

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A, C	protein	151	Homo sapiens	P0DP23 (AlphaFold model)
Unconventional myosin-VIIa	B, D	protein	47	Mus musculus	P97479 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>5WSV_1 Calmodulin (chains A, C)
GPGSMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEV
DADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEK
LTDEEVDEMIREADIDGDGQVNYEEFVQMMT

Sequence of entity 2 (B, D), FASTA

>5WSV_2 Unconventional myosin-VIIa (chains B, D)
GPGSLVRKAFRHRLWAVITVQAYARGMIARRLHRRLRVEYQRRLEAE

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	8

Water and common crystallization additives (SO4) are not listed.

Primary citation

Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension. Li, J., Chen, Y., Deng, Y. et al. Structure (2017) 25:579-591.e4. DOI 10.1016/j.str.2017.02.002 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

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