3PWU: MHC class I antigen

An immmunodominant CTL epitope from rinderpest virus presented by cattle MHC class I molecule N*01801(BoLA-A11). Determined by X-ray diffraction at 1.9 Å resolution. Released 24 Aug 2011.

Method: X-ray diffraction
Resolution: 1.9 Å
Organisms: Bos taurus, Mus musculus
Chains: 3
Atoms: 3,562
Mol. weight: 44.45 kDa
Released: 24 Aug 2011

Explore 3PWU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3PWU contains 10 α-helices and 30 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	2-11	10	1
α-helix	19	1
β-strand	20-27	8	1
β-strand	30-36	7	1
β-strand	45-46	2	1
α-helix	49-51	3
α-helix	56-83	28
β-strand	93-102	10	1
β-strand	108-117	10	1
β-strand	120-125	6	1
β-strand	132-134	3	1
α-helix	137-149	13
α-helix	151-160	10
α-helix	162-178	17
β-strand	182	1	2
α-helix	183-184	2
β-strand	185-192	8	3
β-strand	197-207	11	3
β-strand	208	1	2
β-strand	213-218	6	4
β-strand	221-222	2	4
β-strand	228-229	2	3
β-strand	233-234	2	3
β-strand	240-249	10	3
α-helix	253-255	3
β-strand	256-261	6	4
β-strand	269-271	3	4

Chain B: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-8	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A	protein	274	Bos taurus	Q95477 (AlphaFold model)
Beta-2-microglobulin	B	protein	99	Mus musculus	P01887 (AlphaFold model)
IPA from Hemagglutinin glycoprotein	C	protein	9		P41355

Sequence of entity 1 (A), FASTA

>3PWU_1 MHC class I antigen (chains A)
SHSLRYFYTAVSRPGLGEPRFIAVGYVDDTQFTRFDSDAPNPRDEPRVPWMEQEGPEYWD
RNTRIYKDTAQIFRANLNTALGYYNQSEAGSHTFQEMYGCYVGPDGRLLLGFMQFAYDGR
DYIALNEDLRSWTAADTAAQITKRKWEAAGEAERQRNYLEGRCVEGLRRYLENGKDTLLR
ADPPKAHVTHHPISDREVTLRCWALGFYPEEISLTWQHEGEDQTQDMELVETRPSGDGTF
QKWAALVVPSGEEQRYTCRVQHEGLQEPLTLRWE

Sequence of entity 2 (B), FASTA

>3PWU_2 Beta-2-microglobulin (chains B)
IQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDW
SFYILAHTEFTPTETDTYACRVKHDSMAEPKTVYWDRDM

Sequence of entity 3 (C), FASTA

>3PWU_3 IPA from Hemagglutinin glycoprotein (chains C)
IPAYGVLTI

Primary citation

Two distinct conformations of a rinderpest virus epitope presented by bovine major histocompatibility complex class I N*01801: a host strategy to present featured peptides. Li, X., Liu, J., Qi, J. et al. J Virol (2011) 85:6038-6048. DOI 10.1128/JVI.00030-11 · PubMed

Other PDB entries of the same protein (UniProt Q95477 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3PWV 2.7 Å, An immmunodominant CTL epitope from rinderpest virus presented by cattle MHC class I…

Browse structure collections

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