Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9. Determined by X-ray diffraction at 1.65 Å resolution. Released 19 Oct 2011.
Explore 3TWC in 3D Show helices and sheets RCSB PDB PDBe
3TWC contains 14 α-helices and 46 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-7 | 5 | 7 |
| β-strand | 11-12 | 2 | 8 |
| β-strand | 18-25 | 8 | 7 |
| β-strand | 35-39 | 7 | 9 |
| β-strand | 46-52A | 8 | 9 |
| β-strand | 55-59 | 5 | 9 |
| α-helix | 64-66 | 3 | |
| β-strand | 67-72 | 6 | 7 |
| β-strand | 77-82 | 6 | 7 |
| α-helix | 84-86 | 3 | |
| β-strand | 88-98 | 11 | 9 |
| β-strand | 100G-103 | 8 | 9 |
| β-strand | 107-109 | 3 | 9 |
| β-strand | 110-111 | 2 | 8 |
| α-helix | 114-116 | 3 | |
| β-strand | 117 | 1 | 10 |
| α-helix | 118-119 | 2 | |
| β-strand | 120-124 | 5 | 11 |
| β-strand | 137-147 | 11 | 11 |
| β-strand | 148 | 1 | 10 |
| β-strand | 153-157 | 4 | 12 |
| α-helix | 158-164 | 3 | |
| β-strand | 166 | 1 | 12 |
| β-strand | 170-173 | 3 | 11 |
| α-helix | 174-176 | 3 | |
| β-strand | 177-178 | 2 | 11 |
| β-strand | 185-194 | 10 | 11 |
| α-helix | 195-197 | 3 | |
| β-strand | 207-212 | 6 | 12 |
| α-helix | 213-215 | 3 | |
| β-strand | 217-222 | 6 | 12 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5 | 1 | 1 |
| β-strand | 9-13 | 4 | 2 |
| β-strand | 19-24 | 6 | 1 |
| β-strand | 33-38 | 6 | 2 |
| β-strand | 45-48 | 4 | 2 |
| β-strand | 49 | 1 | 3 |
| β-strand | 53 | 1 | 3 |
| β-strand | 62-67 | 6 | 1 |
| β-strand | 70-75 | 6 | 1 |
| α-helix | 80-82 | 3 | |
| β-strand | 84-92 | 9 | 2 |
| β-strand | 95A-98 | 4 | 2 |
| β-strand | 102-106 | 5 | 2 |
| β-strand | 111 | 1 | 4 |
| α-helix | 112-113 | 2 | |
| β-strand | 114-118 | 5 | 5 |
| α-helix | 119-121 | 3 | |
| α-helix | 122-126 | 5 | |
| β-strand | 130-139 | 10 | 5 |
| β-strand | 140 | 1 | 4 |
| β-strand | 145-150 | 6 | 6 |
| β-strand | 153-155 | 3 | 6 |
| β-strand | 159-161 | 3 | 5 |
| α-helix | 162-164 | 3 | |
| β-strand | 165-166 | 2 | 5 |
| β-strand | 173-181 | 9 | 5 |
| α-helix | 183-188 | 6 | |
| β-strand | 192-198 | 7 | 6 |
| β-strand | 203-209 | 7 | 6 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| PGT127 light chain, Ig lambda-2 chain C regions | L | protein | 211 | Homo sapiens | P0DOY2 (AlphaFold model) |
| PGT127 heavy chain, Ig gamma-1 chain C region | H | protein | 239 | Homo sapiens | P01857 (AlphaFold model) |
>3TWC_1 PGT127 light chain, Ig lambda-2 chain C regions (chains L) QSALTQPPSASGSPGQSITISCTGTSNNFVSWYQQYPGKAPKLVIYEVNKRPSGVPDRFS GSKSGSTASLTVSGLQADDEGVYYCSSLVGNWDVIFGGGTKLTVLGQPKAAPSVTLFPPS SEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLT PEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
>3TWC_2 PGT127 heavy chain, Ig gamma-1 chain C region (chains H) QPQLQESGPGLVEASETLSLTCTVSGDSTGRCNYFWGWVRQPPGKGLEWIGSLSHCRSYY NTDWTYHNPSLKSRLTISLDTPKNQVFLRLTSVTAADTATYYCARFGGEVLVYRDWPKPA WVDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD
| ID | Name | Formula | Copies |
|---|---|---|---|
| AML | Amylamine | C5 H13 N | 1 |
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Pejchal, R., Doores, K.J., Walker, L.M. et al. Science (2011) 334:1097-1103. DOI 10.1126/science.1213256 · PubMed
Other PDB entries of the same protein (UniProt P0DOY2 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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