Serine/threonine-protein kinase 25 (STK25) is a 426-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00506.
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The mean pLDDT of this model is 79.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Oxidant stress-activated serine/threonine kinase that plays a role in metabolic homeostasis, neuronal polarization, cell migration, Golgi organization, apoptosis or innate immunity. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as…
Homodimer. Interacts with CTTNBP2NL (PubMed:18782753). Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26 (PubMed:18782753). Interacts with TAOK3 (via N-terminus); the interaction promotes…
Cytoplasm, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Z4V | X-ray | 1.64 Å | A=1-294 |
| 2XIK | X-ray | 1.97 Å | A=1-293 |
| 3W8H | X-ray | 2.43 Å | B=355-426 |
| 4NZW | X-ray | 3.58 Å | B=1-293 |
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