3ZM2: Catalytic domain of human SHP2

Catalytic domain of human SHP2. Determined by X-ray diffraction at 1.5 Å resolution. Released 23 Apr 2014.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 2,398
Mol. weight: 33.11 kDa
Released: 23 Apr 2014

Explore 3ZM2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3ZM2 contains 14 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	251-254	4
α-helix	267-269	3
α-helix	271-276	6
α-helix	286-288	3
β-strand	289-291	3	1
α-helix	292-293	2
β-strand	304-310	7	1
β-strand	327-331	5	1
α-helix	332-334	3
α-helix	335-337	3
α-helix	338-347	10
β-strand	352-355	4	1
β-strand	360-361	2	2
β-strand	364-365	2	2
α-helix	372-373	2
β-strand	377-380	4	1
β-strand	383-392	10	1
β-strand	396-405	10	1
β-strand	413-420	8	1
α-helix	433-447	15
α-helix	454	1
β-strand	455-459	5	1
α-helix	464-482	19
α-helix	490-498	9
α-helix	508-524	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tyrosine-protein phosphatase non-receptor type 11	A	protein	284	HOMO SAPIENS	Q06124 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3ZM2_1 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 (chains A)
GAHMWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSD
YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG
KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW
PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG
VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQR

Primary citation

Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Grosskopf, S., Eckert, C., Arkona, C. et al. ChemMedChem (2015) 10:815. DOI 10.1002/CMDC.201500015 · PubMed

Other PDB entries of the same protein (UniProt Q06124 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9EIK 1.25 Å, Crystal structure of N-SH2 domain of SHP2 with T42A mutation bound to GAB1 tyrosine…
3ZM1 1.4 Å, Catalytic domain of human SHP2
4JMG 1.4 Å, Crystal structure of the synthetic protein in complex with pY peptide
7PPM 1.48 Å, SHP2 catalytic domain in complex with IRS1 (889-901) phosphopeptide (pSer-892, pTyr-896)
3ZM0 1.5 Å, Catalytic domain of human SHP2
3ZM3 1.5 Å, Catalytic domain of human SHP2
7PPL 1.53 Å, SHP2 catalytic domain in complex with IRS1 (625-639) phosphopeptide (pTyr-632, pSer-636)
9EIC 1.58 Å, Crystal structure of unbound N-SH2 domain of SHP2 with T42A mutation
9EHD 1.59 Å, Crystal structure of N-SH2 domain of SHP2 bound to GAB1 tyrosine phosphorylated peptide…
3B7O 1.6 Å, Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible…
4RDD 1.6 Å, Co-crystal structure of SHP2 in complex with a Cefsulodin derivative
5EHR 1.7 Å, Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099

Browse structure collections

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