3ZNG: Ankyrin repeat and SOCS-box protein 9
Ankyrin repeat and SOCS-box protein 9 (ASB9) in complex with ElonginB and ElonginC. Determined by X-ray diffraction at 2.85 Å resolution. Released 4 Dec 2013.
- Method
- X-ray diffraction
- Resolution
- 2.85 Å
- Organism
- HOMO SAPIENS
- Chains
- 6
- Atoms
- 6,525
- Mol. weight
- 107.16 kDa
- Released
- 4 Dec 2013
Explore 3ZNG in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
3ZNG contains 55 α-helices and 32 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 18 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 39-46 | 8 | |
| α-helix | 49-58 | 10 | |
| α-helix | 72-78 | 7 | |
| α-helix | 82-90 | 9 | |
| α-helix | 105-112 | 8 | |
| α-helix | 115-123 | 9 | |
| α-helix | 137-143 | 7 | |
| α-helix | 147-155 | 9 | |
| β-strand | 164 | 1 | 1 |
| β-strand | 168 | 1 | 1 |
| α-helix | 170-176 | 7 | |
| α-helix | 180-189 | 10 | |
| β-strand | 197 | 1 | 2 |
| β-strand | 200 | 1 | 2 |
| α-helix | 202-209 | 8 | |
| α-helix | 212-220 | 9 | |
| α-helix | 235-238 | 4 | |
| α-helix | 244-251 | 8 | |
| α-helix | 255-257 | 3 | |
| α-helix | 258-267 | 10 | |
| α-helix | 275-280 | 6 | |
| α-helix | 285-291 | 7 | |
Chain B: 5 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 19-22 | 4 | 3 |
| β-strand | 28-31 | 4 | 3 |
| α-helix | 33-36 | 4 | |
| α-helix | 40-45 | 6 | |
| β-strand | 60-61 | 2 | 3 |
| α-helix | 67-82 | 16 | |
| α-helix | 89-92 | 4 | |
| α-helix | 97-110 | 14 | |
Chain C: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-9 | 7 | 3 |
| β-strand | 12-18 | 7 | 3 |
| α-helix | 24-35 | 12 | |
| β-strand | 68 | 1 | 4 |
| β-strand | 71 | 1 | 4 |
| α-helix | 72 | 1 | |
| β-strand | 73-74 | 2 | 3 |
| α-helix | 92-100 | 9 | |
Chain D: 18 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 39-46 | 8 | |
| α-helix | 49-58 | 10 | |
| α-helix | 72-79 | 8 | |
| α-helix | 82-90 | 9 | |
| α-helix | 105-112 | 8 | |
| α-helix | 115-123 | 9 | |
| α-helix | 137-143 | 7 | |
| α-helix | 147-155 | 9 | |
| β-strand | 164 | 1 | 5 |
| β-strand | 168 | 1 | 5 |
| α-helix | 170-176 | 7 | |
| α-helix | 180-189 | 10 | |
| β-strand | 197 | 1 | 6 |
| β-strand | 200 | 1 | 6 |
| α-helix | 202-209 | 8 | |
| α-helix | 212-220 | 9 | |
| α-helix | 235-238 | 4 | |
| α-helix | 244-251 | 8 | |
| α-helix | 255-257 | 3 | |
| α-helix | 258-268 | 11 | |
| α-helix | 275-280 | 6 | |
| α-helix | 285-291 | 7 | |
Chain E: 5 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 19-22 | 4 | 7 |
| β-strand | 28-31 | 4 | 7 |
| α-helix | 33-36 | 4 | |
| α-helix | 40-45 | 6 | |
| β-strand | 60-61 | 2 | 7 |
| α-helix | 67-83 | 17 | |
| α-helix | 90-92 | 3 | |
| α-helix | 97-110 | 14 | |
Chain F: 6 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-9 | 7 | 7 |
| β-strand | 10 | 1 | 8 |
| β-strand | 12-18 | 7 | 7 |
| β-strand | 23 | 1 | 9 |
| α-helix | 24-35 | 12 | |
| α-helix | 39-41 | 3 | |
| β-strand | 42-46 | 5 | 7 |
| β-strand | 49-50 | 2 | 7 |
| β-strand | 56 | 1 | 9 |
| β-strand | 68 | 1 | 10 |
| β-strand | 71 | 1 | 10 |
| α-helix | 72 | 1 | |
| β-strand | 73-79 | 7 | 7 |
| β-strand | 80-81 | 2 | 11 |
| β-strand | 84-85 | 2 | 11 |
| α-helix | 86-88 | 3 | |
| β-strand | 90 | 1 | 8 |
| α-helix | 94-100 | 7 | |
| α-helix | 101-103 | 3 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Ankyrin repeat and socs box protein 9 | A, D | protein | 268 | HOMO SAPIENS | Q96DX5 (AlphaFold model) |
| Transcription elongation factor B polypeptide 1 | B, E | protein | 97 | HOMO SAPIENS | Q15369 (AlphaFold model) |
| Transcription elongation factor B polypeptide 2 | C, F | protein | 118 | HOMO SAPIENS | Q15370 (AlphaFold model) |
Sequence of entity 1 (A, D), FASTA
>3ZNG_1 ANKYRIN REPEAT AND SOCS BOX PROTEIN 9 (chains A, D)
MSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGA
QVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSL
IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEE
LACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQ
QHHKITKLVLPEDLKQFLLHLAENLYFQ
Sequence of entity 2 (B, E), FASTA
>3ZNG_2 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 (chains B, E)
MMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCM
YFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
Sequence of entity 3 (C, F), FASTA
>3ZNG_3 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 (chains C, F)
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGEC
GFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
Primary citation
Multimeric Complexes Among Ankyrin-Repeat and Socs-Box Protein 9 (Asb9), Elonginbc, and Cullin 5: Insights Into the Structure and Assembly of Ecs-Type Cullin-Ring E3 Ubiquitin Ligases. Thomas, J.C., Matak-Vinkovic, D., Van Molle, I. et al. Biochemistry (2013) 52:5236. DOI 10.1021/BI400758H · PubMed
Other PDB entries of the same protein (UniProt Q96DX5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3D9H 2.2 Å, Crystal Structure of the Splice Variant of Human ASB9 (hASB9-2), an Ankyrin Repeat Protein
- 3ZKJ 2.58 Å, Crystal Structure of Ankyrin Repeat and Socs Box-Containing Protein 9 (Asb9) in Complex…
- 6V9H 4.1 Å, Ankyrin repeat and SOCS-box protein 9 (ASB9), ElonginB (ELOB), and ElonginC (ELOC) bound…
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