3ZNH: Crimean Congo Hemorrhagic Fever Virus OTU domain

Crimean Congo Hemorrhagic Fever Virus OTU domain in complex with ubiquitin-propargyl. Determined by X-ray diffraction at 2.3 Å resolution. Released 27 Feb 2013.

Method: X-ray diffraction
Resolution: 2.3 Å
Organisms: CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS, HOMO SAPIENS
Chains: 2
Atoms: 1,822
Mol. weight: 29.42 kDa
Released: 27 Feb 2013

Explore 3ZNH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3ZNH contains 11 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	10-13	4	1
β-strand	16-19	4	1
β-strand	24	1	2
α-helix	25-27	3
β-strand	29-32	4	1
α-helix	40-49	10
α-helix	58-72	15
α-helix	73-75	3
α-helix	79-82	4
α-helix	86-93	8
β-strand	101	1	3
α-helix	102-111	10
β-strand	116-121	6	1
β-strand	126	1	2
β-strand	127-133	7	1
β-strand	142-147	6	1
β-strand	151-157	7	1

Chain B: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	4
β-strand	12-16	5	4
β-strand	22	1	5
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	4
β-strand	48-49	2	4
α-helix	50-51	2
β-strand	55	1	5
β-strand	66-71	6	4
α-helix	72	1
β-strand	74	1	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin thioesterase	A	protein	183	CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS	Q6TQR6 (AlphaFold model)
Polyubiquitin-B	B	protein	76	HOMO SAPIENS	P0CG47 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3ZNH_1 UBIQUITIN THIOESTERASE (chains A)
MDFLRSLDWTQVIAGQYVSNPRFNISDYFEIVRQPGDGNCFYHSIAELTMPNKTDHSYHY
IKRLTESAARKYYQEEPEARLVGLSLEDYLKRMLSDNEWGSTLEASMLAKEMGITIIIWT
VAASDEVEAGIKFGDGDVFTAVNLLHSGQTHFDALRILPQFETDTREALSLMDRVIAVDQ
LTS

Sequence of entity 2 (B), FASTA

>3ZNH_2 POLYUBIQUITIN-B (chains B)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGX

Primary citation

On Terminal Alkynes that Can React with Active-Site Cysteine Nucleophiles in Proteases. Ekkebus, R., Van Kasteren, S.I., Kulathu, Y. et al. J Am Chem Soc (2013) 135:2867. DOI 10.1021/JA309802N · PubMed

Other PDB entries of the same protein (UniProt Q6TQR6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5V5H 1.5 Å, OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.2
3PHX 1.6 Å, OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with ISG15
3PRP 1.7 Å, Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic…
3PHW 2.0 Å, OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin
5V5G 2.1 Å, OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.4
3PHU 2.2 Å, OTU Domain of Crimean Congo Hemorrhagic Fever Virus
5V5I 2.2 Å, OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.1
3PRM 2.3 Å, Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic…
3PSE 2.3 Å, Structure of a viral OTU domain protease bound to interferon-stimulated gene 15 (ISG15)
9T0E 2.3 Å, Structure of Crimean Congo hemorrhagic fever virus (CCHFV) L protein bound to 5' vRNA…
22TH 2.5 Å, Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in complex…
3PT2 2.5 Å, Structure of a viral OTU domain protease bound to Ubiquitin

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