6-conformation model of SARS-CoV-2 NSP3 macrodomain (C2 crystal form, 100 K). Determined by X-ray diffraction at 0.77 Å resolution. Released 30 Sept 2026.
Explore 44PS in 3D Show helices and sheets RCSB PDB PDBe
44PS contains 13 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 8 | 1 | |
| β-strand | 9-10 | 2 | 1 |
| β-strand | 15-18 | 4 | 1 |
| α-helix | 22-29 | 8 | |
| β-strand | 33-37 | 5 | 1 |
| α-helix | 47-55 | 9 | |
| α-helix | 59-71 | 13 | |
| α-helix | 73-75 | 3 | |
| β-strand | 79-83 | 5 | 1 |
| β-strand | 90-94 | 5 | 1 |
| α-helix | 99-101 | 3 | |
| α-helix | 105-107 | 3 | |
| α-helix | 108-113 | 6 | |
| α-helix | 114-117 | 4 | |
| β-strand | 120-124 | 5 | 1 |
| α-helix | 125 | 1 | |
| α-helix | 129-131 | 3 | |
| α-helix | 135-145 | 11 | |
| β-strand | 149-153 | 5 | 1 |
| α-helix | 157-168 | 12 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Papain-like protease nsp3 | A | protein | 173 | Severe acute respiratory syndrome coronavirus 2 | P0DTD1 (AlphaFold model) |
>44PS_1 Papain-like protease nsp3 (chains A) SNAGEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKAT NNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFN QHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLE
Optimizing the connectivity of protein conformations to untangle ensemble refinement. Passmore, S.K., Holton, J.M., Zatsepin, N.A. et al. bioRxiv (2026). DOI 10.64898/2026.09.17.752399
Other PDB entries of the same protein (UniProt P0DTD1 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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