4A0I: Survivin

Crystal structure of Survivin bound to the N-terminal tail of hSgo1. Determined by X-ray diffraction at 2.6 Å resolution. Released 9 Nov 2011.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: HOMO SAPIENS
Chains: 4
Atoms: 2,166
Mol. weight: 34.18 kDa
Ligands: ZN
Released: 9 Nov 2011

Explore 4A0I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4A0I contains 14 α-helices and 10 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	8-13	6
α-helix	15-20	6
α-helix	35-40	6
β-strand	43-45	3	1
β-strand	55-57	3	1
β-strand	63-65	3	1
α-helix	73-80	8
α-helix	85-88	4
α-helix	93-95	3
β-strand	97	1	2
α-helix	98-139	42

Chain B: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
α-helix	15-19	5
α-helix	35-40	6
β-strand	43-45	3	3
β-strand	55-57	3	3
β-strand	63-65	3	3
α-helix	73-80	8
α-helix	85-88	4
α-helix	93-95	3
β-strand	97	1	2
α-helix	98-138	41

Chains C and D: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2-3	2	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Baculoviral iap repeat-containing protein 5	A, B	protein	142	HOMO SAPIENS	O15392 (AlphaFold model)
Shugoshin-like 1	C, D	protein	5	HOMO SAPIENS	Q5FBB7 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>4A0I_1 BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5 (chains A, B)
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAKKVRRAIEQLAAMD

Sequence of entity 2 (C, D), FASTA

>4A0I_2 SHUGOSHIN-LIKE 1 (chains C, D)
AKERC

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	2

Primary citation

Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex. Jeyaprakash, A.A., Basquin, C., Jayachandran, U. et al. Structure (2011) 19:1625. DOI 10.1016/J.STR.2011.09.002 · PubMed

Other PDB entries of the same protein (UniProt O15392 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2QFA 1.4 Å, Crystal structure of a Survivin-Borealin-INCENP core complex
9TPI 1.8 Å, Survivin 1-122 in complex with a molecular tweezer-Histone-H3-peptide conjugate
6YIF 1.81 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
9TPH 2.0 Å, Survivin 1-127 in complex with a molecular tweezer-Histone-H3-peptide conjugate
3UEC 2.18 Å, Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.
2RAW 2.4 Å, Crystal structure of the Borealin-Survivin complex
3UIG 2.4 Å, crystal structure of human Survivin in complex with T3 phosphorylated H3(1-15) peptide
3UIH 2.4 Å, crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide
8RUP 2.42 Å, Chromosome Passenger Complex (CPC) localization module in complex with H3.T3p-nucleosome
3UEF 2.45 Å, Crystal structure of human Survivin bound to histone H3 (C2 space group).
7LBO 2.5 Å, Crystal structure of human Survivin bound to histone H3 T3phK4me1 peptide
6YIH 2.55 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…

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