2QFA: Survivin-Borealin-INCENP core complex

Crystal structure of a Survivin-Borealin-INCENP core complex. Determined by X-ray diffraction at 1.4 Å resolution. Released 6 Nov 2007.

Method: X-ray diffraction
Resolution: 1.4 Å
Organism: Homo sapiens
Chains: 3
Atoms: 2,429
Mol. weight: 29.87 kDa
Ligands: ZN
Released: 6 Nov 2007

Explore 2QFA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2QFA contains 13 α-helices and 7 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
α-helix	15-20	6
α-helix	35-40	6
β-strand	43-45	3	1
β-strand	48	1	2
β-strand	51	1	2
β-strand	55-57	3	1
β-strand	63-64	2	1
α-helix	73-80	8
α-helix	85-88	4
α-helix	93-95	3
β-strand	97	1	3
α-helix	98-139	42

Chain B: 3 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	16-60	45
α-helix	63-66	4
β-strand	69	1	3
α-helix	70-75	6

Chain C: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	10-26	17
α-helix	27-31	5
α-helix	32-45	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Baculoviral IAP repeat-containing protein 5	A	protein	142	Homo sapiens	O15392 (AlphaFold model)
Borealin	B	protein	62	Homo sapiens	Q53HL2 (AlphaFold model)
Inner centromere protein	C	protein	47	Homo sapiens	Q9NQS7 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2QFA_1 Baculoviral IAP repeat-containing protein 5 (chains A)
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAKKVRRAIEQLAAMD

Sequence of entity 2 (B), FASTA

>2QFA_2 Borealin (chains B)
SLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYF
AL

Sequence of entity 3 (C), FASTA

>2QFA_3 Inner centromere protein (chains C)
MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Water and common crystallization additives (MES) are not listed.

Primary citation

Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Jeyaprakash, A.A., Klein, U.R., Lindner, D. et al. Cell (2007) 131:271-285. DOI 10.1016/j.cell.2007.07.045 · PubMed

Other PDB entries of the same protein (UniProt O15392 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9TPI 1.8 Å, Survivin 1-122 in complex with a molecular tweezer-Histone-H3-peptide conjugate
6YIF 1.81 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
9TPH 2.0 Å, Survivin 1-127 in complex with a molecular tweezer-Histone-H3-peptide conjugate
3UEC 2.18 Å, Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.
2RAW 2.4 Å, Crystal structure of the Borealin-Survivin complex
3UIG 2.4 Å, crystal structure of human Survivin in complex with T3 phosphorylated H3(1-15) peptide
3UIH 2.4 Å, crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide
8RUP 2.42 Å, Chromosome Passenger Complex (CPC) localization module in complex with H3.T3p-nucleosome
3UEF 2.45 Å, Crystal structure of human Survivin bound to histone H3 (C2 space group).
7LBO 2.5 Å, Crystal structure of human Survivin bound to histone H3 T3phK4me1 peptide
6YIH 2.55 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
1F3H 2.58 Å, X-ray crystal structure of the human anti-apoptotic protein survivin

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