4B8B: N-Terminal domain of the yeast Not1

N-Terminal domain of the yeast Not1. Determined by X-ray diffraction at 2.8 Å resolution. Released 21 Nov 2012.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
SACCHAROMYCES CEREVISIAE S288C
Chains
2
Atoms
8,410
Mol. weight
142.91 kDa
Ligands
AU
Released
21 Nov 2012

Explore 4B8B in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4B8B contains 83 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 42 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix194-1974
α-helix198-2003
α-helix201-2077
α-helix234-24512
α-helix249-2513
α-helix254-26310
α-helix275-28511
α-helix288-2969
α-helix301-31212
α-helix323-3253
β-strand33111
α-helix343-3453
β-strand34611
α-helix347-35812
α-helix367-38216
α-helix384-39310
α-helix395-4028
α-helix405-42117
α-helix424-4263
α-helix427-4337
α-helix437-45014
α-helix457-4648
α-helix468-4747
α-helix4761
α-helix479-4824
α-helix484-4907
α-helix495-5028
α-helix508-52013
α-helix536-54712
α-helix553-56917
α-helix571-5733
α-helix581-5855
α-helix595-60915
α-helix615-62612
α-helix631-64717
α-helix648-6536
α-helix656-67116
α-helix677-69115
α-helix6941
α-helix698-70912
α-helix711-7166
α-helix718-72710
α-helix729-7335
α-helix735-7439
Chain B: 41 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix194-1974
α-helix200-2067
α-helix235-24511
α-helix249-2513
α-helix254-26310
α-helix275-28511
α-helix288-2969
α-helix301-31212
α-helix316-3183
β-strand33112
α-helix343-3453
β-strand34612
α-helix347-35812
α-helix360-3623
α-helix367-38216
α-helix384-39310
α-helix395-4028
α-helix405-42117
α-helix424-4263
α-helix427-4326
α-helix437-45014
α-helix457-4648
α-helix468-4747
α-helix4761
α-helix480-49011
α-helix495-5028
α-helix508-52013
α-helix536-54813
α-helix553-56917
α-helix571-5733
α-helix581-5855
α-helix595-60915
α-helix615-62511
α-helix631-64717
α-helix648-6536
α-helix656-67116
α-helix677-69115
α-helix6941
α-helix698-70912
α-helix711-7166
α-helix718-72710
α-helix729-7335
α-helix735-7428

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
General negative regulator of transcription subunit 1A, Bprotein603SACCHAROMYCES CEREVISIAE S288CP25655 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4B8B_1 GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 1 (chains A, B)
RSSQINDFKTIKMNHTNYLRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILS
PGSQNLQNDPTRSWLTPPMVLDATNRGNVIARSISSLQANQINWNRVFNLMSTKYFLSAP
LMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGCFDLLNAEGTR
KVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFFEDFNYAPEYLILA
LVKEMKRFVLLIENRTVIDEILITLLIQVHNKSPSSFKDVISTITDDSKIVDAAKIIINS
DDAPIANFLKSLLDTGRLDTVINKLPFNEAFKILPCARQIGWEGFDTFLKTKVSPSNVDV
VLESLEVQTKMTDTNTPFRSLKTFDLFAFHSLIEVLNKCPLDVLQLQRFESLEFSLLIAF
PRLINFGFGHDEAILANGDIAGINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDL
PRDQEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMILFQLLRGFVLDVAFRIIMRF
AKEPPESKMFKFAVQAIYAFRIRLAEYPQYCKDLLRDVPALKSQAQVYQSIVEAATLANA
PKE

Ligands and cofactors

IDNameFormulaCopies
AUGold ionAu29

Primary citation

Architecture of the Nuclease Module of the Yeast Ccr4-not Complex: The not1-Caf1-Ccr4 Interaction. Basquin, J., Roudko, V.V., Rode, M. et al. Mol Cell (2012) 48:207. DOI 10.1016/J.MOLCEL.2012.08.014 · PubMed

Other PDB entries of the same protein (UniProt P25655 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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