4BXO: Fanconi anemia group M protein

Architecture and DNA recognition elements of the Fanconi anemia FANCM- FAAP24 complex. Determined by X-ray diffraction at 2.15 Å resolution. Released 28 Aug 2013.

Method: X-ray diffraction
Resolution: 2.15 Å
Organisms: HOMO SAPIENS, SYNTHETIC CONSTRUCT
Chains: 4
Atoms: 3,617
Mol. weight: 59.69 kDa
Ligands: CA
Released: 28 Aug 2013

Explore 4BXO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4BXO contains 26 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	1819-1823	5	1
α-helix	1826-1829	4
α-helix	1831-1838	8
β-strand	1844-1848	5	1
β-strand	1855-1856	2	1
β-strand	1861-1867	7	1
α-helix	1868-1872	5
α-helix	1877-1888	12
β-strand	1893-1899	7	1
α-helix	1916-1927	12
β-strand	1931-1935	5	1
α-helix	1938-1954	17
α-helix	1970-1977	8
α-helix	1984-1993	10
α-helix	1997-2001	5
α-helix	2005-2012	8
α-helix	2016-2027	12
α-helix	2032-2034	3

Chain B: 14 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	18-22	5	2
α-helix	23-25	3
α-helix	29-35	7
β-strand	39-43	5	2
β-strand	50-51	2	2
β-strand	56-61	6	2
α-helix	63-68	6
α-helix	73-80	8
β-strand	86-92	7	2
α-helix	98-100	3
α-helix	101-105	5
α-helix	106-111	6
β-strand	115-119	5	2
α-helix	122-137	16
α-helix	140-142	3
α-helix	156-163	8
α-helix	173-180	8
α-helix	184-188	5
α-helix	192-195	4
α-helix	201-212	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Fanconi anemia group M protein	A	protein	254	HOMO SAPIENS	Q8IYD8 (AlphaFold model)
Fanconi anemia-associated protein of 24 kda	B	protein	217	HOMO SAPIENS	Q9BTP7 (AlphaFold model)
5'-d(tpcpapgpcpaptpcpaptp*cp)-3'	H	DNA	11	SYNTHETIC CONSTRUCT
5'-d(gpaptpgpaptpgpcptpgp*cp)-3'	I	DNA	11	SYNTHETIC CONSTRUCT

Sequence of entity 1 (A), FASTA

>4BXO_1 FANCONI ANEMIA GROUP M PROTEIN (chains A)
GSGSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCD
YIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRR
TKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQ
FYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQM
LPNDLNQDRLKSDI

Sequence of entity 2 (B), FASTA

>4BXO_2 FANCONI ANEMIA-ASSOCIATED PROTEIN OF 24 KDA (chains B)
GSHMEKNPPDDTGPVHVPLGHIVANEKWRGSQLAEEMQGKIKLIFEDGLTPDFYLSNRCC
ILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLL
PVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLL
LQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQP

Sequence of entity 3 (H), FASTA

>4BXO_3 5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*AP*TP*CP)-3' (chains H)
GATGATGCTGA

Sequence of entity 4 (I), FASTA

>4BXO_4 5'-D(*GP*AP*TP*GP*AP*TP*GP*CP*TP*GP*CP)-3' (chains I)
TCAGCATCATC

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Architecture and DNA Recognition Elements of the Fanconi Anemia Fancm-Faap24 Complex. Coulthard, R., Deans, A.J., Swuec, P. et al. Structure (2013) 21:1648. DOI 10.1016/J.STR.2013.07.006 · PubMed

Other PDB entries of the same protein (UniProt Q8IYD8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4E45 2.0 Å, Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi…
9EL5 2.2 Å, FANCM translocase domain bound to DNA
9HJO 2.4 Å, FANCM-FAAP24-dsDNA complex
4DRB 2.63 Å, The crystal structure of FANCM bound MHF complex
4M6W 2.9 Å, Crystal structure of the C-terminal segment of FANCM in complex with FAAP24
4DAY 3.3 Å, Crystal structure of the RMI core complex with MM2 peptide from FANCM

Browse structure collections

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