4C2M: RNA polymerase I

Name: PDB 4C2M: Structure of RNA polymerase I at 2.8 A resolution
Published: 2013-10-23
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structure of RNA polymerase I at 2.8 A resolution. Determined by X-ray diffraction at 2.8 Å resolution. Released 23 Oct 2013.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: SACCHAROMYCES CEREVISIAE
Chains: 30
Atoms: 69,107
Mol. weight: 1254.19 kDa
Ligands: ZN
Released: 23 Oct 2013

Explore 4C2M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4C2M contains 465 α-helices and 495 β-strands across 30 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains 1 and L: 1 helix, 4 β-strands

Element	Residues	Length	Sheet
β-strand	29-31	3	1
β-strand	37-38	2	1
β-strand	55-58	4	1
α-helix	59-60	2
β-strand	65-68	4	2

Chain 2: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	11-16	6	4
β-strand	22-25	4	5
β-strand	37-42	6	5
β-strand	51-56	6	5
β-strand	60-66	7	5
α-helix	70-72	3
β-strand	74-82	9	4
β-strand	87-92	6	4
β-strand	95-102	8	5
α-helix	103-106	4

Chains 3 and N: 8 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	30-31	2	5
α-helix	35-37	3
β-strand	52-59	8	4
β-strand	79-82	4	4
β-strand	85-91	7	4
α-helix	93-96	4
β-strand	107-112	6	5
β-strand	119-121	3	5
β-strand	123	1	10
α-helix	129	1
β-strand	130	1	10
α-helix	131	1
β-strand	135-141	7	4
α-helix	145-148	4
α-helix	150-153	4
α-helix	156-163	8
α-helix	177-179	3

Chains 4 and O: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	273-293	21
α-helix	297-299	3
β-strand	301	1	12
β-strand	307	1	12
β-strand	308-309	2	13

Chain A: 100 helices, 70 β-strands

Element	Residues	Length	Sheet
β-strand	10-18	9	15
α-helix	21-27	7
β-strand	31	1	16
β-strand	34	1	17
β-strand	38	1	18
α-helix	43	1
β-strand	44	1	18
α-helix	45	1
β-strand	48	1	17
α-helix	52-54	3
α-helix	61-62	2
β-strand	77-86	10	16
α-helix	88-90	3
α-helix	91-100	10
β-strand	101	1	19
β-strand	108	1	19
α-helix	112-126	15
α-helix	130-135	6
α-helix	136-138	3
α-helix	175-198	24
β-strand	203	1	20
β-strand	206	1	20
α-helix	210-228	19
α-helix	240-241	2
β-strand	242-245	4	21
β-strand	251-254	4	21
α-helix	255-257	3
α-helix	258-266	9
β-strand	314	1	21
α-helix	317-330	14
α-helix	332-338	7
α-helix	352-355	4
β-strand	356-362	7	16
α-helix	363-364	2
α-helix	365-367	3
β-strand	371-373	3	22
β-strand	376-378	3	22
α-helix	381-404	24
α-helix	415-438	24
α-helix	440-442	3
α-helix	444-446	3
α-helix	452-454	3
α-helix	456-461	6
α-helix	466-470	5
β-strand	474-476	3	23
β-strand	479-486	8	24
β-strand	494-497	4	24
α-helix	499-502	4
β-strand	506-510	5	25
α-helix	511	1
α-helix	516-525	10
β-strand	533-537	5	25
β-strand	543-545	3	25
α-helix	551-558	8
α-helix	568-570	3
β-strand	576-580	5	25
α-helix	581	1
β-strand	586-590	5	24
α-helix	597-599	3
β-strand	600-607	8	24
β-strand	614-616	3	24
α-helix	618-620	3
α-helix	621-624	4
β-strand	632-636	5	24
α-helix	641-649	9
β-strand	652	1	24
α-helix	653-656	4
β-strand	658	1	26
β-strand	665	1	26
α-helix	672-680	9
β-strand	686-688	3	27
α-helix	689-700	12
α-helix	715-717	3
β-strand	719-721	3	27
β-strand	725-727	3	27
α-helix	728-739	12
α-helix	745-747	3
β-strand	749-752	4	28
α-helix	757-759	3
β-strand	768-772	5	28
β-strand	775-778	4	28
α-helix	783-786	4
α-helix	793-824	32
β-strand	826-827	2	29
α-helix	830-833	4
α-helix	834	1
β-strand	835	1	30
α-helix	836	1
α-helix	837-847	11
α-helix	848-850	3
α-helix	853-861	9
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	30
α-helix	924-931	8
α-helix	937-944	8
β-strand	948-949	2	31
β-strand	952	1	32
β-strand	955	1	32
α-helix	970	1
α-helix	976-979	4
β-strand	981-982	2	31
β-strand	985	1	33
β-strand	989	1	33
α-helix	992-1011	20
α-helix	1017-1027	11
β-strand	1031-1032	2	34
β-strand	1038-1039	2	34
β-strand	1045-1047	3	34
β-strand	1055	1	35
α-helix	1057-1059	3
α-helix	1066-1070	5
α-helix	1073-1080	8
α-helix	1082-1088	7
β-strand	1090	1	36
α-helix	1093-1107	15
α-helix	1113-1115	3
α-helix	1123-1126	4
β-strand	1132	1	36
α-helix	1138-1150	13
α-helix	1152-1155	4
α-helix	1163-1175	13
β-strand	1178	1	35
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1196-1200	5
α-helix	1218-1226	9
β-strand	1237-1241	5	37
β-strand	1242	1	38
α-helix	1248-1258	11
β-strand	1261-1262	2	39
α-helix	1263-1266	4
β-strand	1267-1275	9	40
β-strand	1288-1296	9	40
α-helix	1297-1298	2
α-helix	1299-1306	8
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1335	14
β-strand	1348	1	41
α-helix	1364-1366	3
α-helix	1369-1378	10
α-helix	1385-1387	3
α-helix	1389-1394	6
α-helix	1442-1452	11
β-strand	1457-1462	6	40
β-strand	1469-1476	8	40
α-helix	1480-1482	3
α-helix	1485-1493	9
β-strand	1497-1499	3	39
β-strand	1507-1508	2	37
β-strand	1513	1	42
β-strand	1516	1	42
β-strand	1518-1522	5	37
α-helix	1526-1529	4
α-helix	1530-1532	3
β-strand	1536	1	38
α-helix	1538-1540	3
β-strand	1542-1543	2	37
α-helix	1546-1553	8
α-helix	1555-1572	18
α-helix	1579-1589	11
α-helix	1600-1603	4
α-helix	1609-1613	5
α-helix	1618-1627	10
β-strand	1631-1632	2	15
α-helix	1637-1643	7
α-helix	1645-1647	3
α-helix	1650-1652	3
β-strand	1654-1660	7	43

Chain B: 56 helices, 73 β-strands

Element	Residues	Length	Sheet
α-helix	18-26	9
α-helix	36-50	15
α-helix	60-68	9
β-strand	71-74	4	44
β-strand	94-104	11	44
β-strand	108-109	2	45
β-strand	119-120	2	45
α-helix	123-129	7
β-strand	134-145	12	44
β-strand	150-162	13	44
α-helix	177-182	6
β-strand	194-196	3	46
β-strand	199-203	5	46
β-strand	205-209	5	47
α-helix	210	1
β-strand	211	1	41
β-strand	214-218	5	41
α-helix	220-225	6
β-strand	229-239	11	41
β-strand	245-253	9	41
β-strand	258-264	7	41
β-strand	267-272	6	41
α-helix	273-280	8
α-helix	285-293	9
α-helix	300-313	14
α-helix	323-334	12
α-helix	346-357	12
α-helix	360-362	3
α-helix	367-385	19
α-helix	390-392	3
α-helix	397-399	3
β-strand	400-403	4	47
α-helix	405-434	30
α-helix	443-451	9
α-helix	457-467	11
β-strand	485-487	3	46
α-helix	493-499	7
β-strand	502-504	3	47
α-helix	507-510	4
α-helix	522-524	3
β-strand	528	1	48
β-strand	543-544	2	47
β-strand	545	1	48
β-strand	550-551	2	49
α-helix	561-567	7
α-helix	570	1
β-strand	571-572	2	50
α-helix	573-575	3
β-strand	584-588	5	50
β-strand	591-596	6	50
α-helix	598-614	17
β-strand	625-629	5	50
α-helix	637-638	2
β-strand	639-643	5	50
β-strand	649-650	2	49
β-strand	651-655	5	51
β-strand	660-664	5	51
α-helix	666-669	4
β-strand	674-675	2	51
α-helix	678-680	3
β-strand	688-689	2	51
α-helix	693-696	4
α-helix	699-703	5
α-helix	707-709	3
β-strand	710	1	52
α-helix	712-722	11
β-strand	725	1	53
α-helix	733-735	3
β-strand	740-744	5	54
β-strand	748	1	55
β-strand	752-753	2	56
α-helix	755-759	5
α-helix	762-764	3
β-strand	769-775	7	53
β-strand	776-777	2	29
β-strand	786-790	5	53
α-helix	791-795	5
β-strand	801-810	10	54
α-helix	819-821	3
β-strand	823-825	3	57
α-helix	835-838	4
β-strand	840	1	58
β-strand	846	1	58
α-helix	847	1
β-strand	851-852	2	54
β-strand	857-863	7	57
β-strand	868-873	6	57
β-strand	880-888	9	54
α-helix	896-898	3
β-strand	900-909	10	54
β-strand	916-919	4	53
β-strand	924-931	8	53
β-strand	938-939	2	59
α-helix	943-945	3
β-strand	947-949	3	53
α-helix	951-953	3
β-strand	959	1	52
α-helix	960-975	16
β-strand	979-980	2	56
β-strand	987	1	60
β-strand	990	1	60
α-helix	992-1003	12
β-strand	1010-1011	2	53
β-strand	1013-1014	2	59
β-strand	1021	1	59
α-helix	1022	1
β-strand	1026-1036	11	53
α-helix	1037-1038	2
β-strand	1045-1047	3	24
β-strand	1052-1053	2	61
β-strand	1059	1	61
α-helix	1060	1
α-helix	1067-1068	2
β-strand	1069-1071	3	23
α-helix	1073-1082	10
α-helix	1085-1089	5
α-helix	1090-1094	5
β-strand	1098-1104	7	62
β-strand	1113-1115	3	63
α-helix	1118-1119	2
β-strand	1126-1128	3	63
β-strand	1133-1134	2	64
α-helix	1135-1139	5
α-helix	1155-1157	3
β-strand	1158-1160	3	64
β-strand	1166-1168	3	64
β-strand	1173-1179	7	62
α-helix	1180-1191	12
β-strand	1194-1201	8	15

Chain C: 16 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-46	6	65
β-strand	51-57	7	65
α-helix	61-73	13
β-strand	77-88	12	66
α-helix	94-103	10
α-helix	105	1
β-strand	106-107	2	67
α-helix	110-112	3
α-helix	114-117	4
α-helix	122-125	4
β-strand	132-139	8	66
β-strand	141-142	2	68
α-helix	153-156	4
β-strand	157-158	2	68
β-strand	161-163	3	69
α-helix	164-166	3
β-strand	168-170	3	66
α-helix	175-178	4
β-strand	185-186	2	67
β-strand	192-195	4	69
β-strand	201-211	11	66
α-helix	217-219	3
β-strand	222-235	14	65
β-strand	240	1	70
α-helix	242-248	7
β-strand	256-258	3	71
β-strand	264	1	70
β-strand	265-267	3	71
α-helix	270-272	3
α-helix	278-281	4
α-helix	283-286	4
β-strand	289-304	16	65
α-helix	310-329	20
β-strand	334	1	72

Chain D: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	73
β-strand	29-30	2	73
α-helix	33-46	14
α-helix	81-95	15

16 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerases I, II, and III subunit rpabc 4	1, L	protein	70	SACCHAROMYCES CEREVISIAE	P40422 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA49	2, M	protein	415	SACCHAROMYCES CEREVISIAE	Q01080 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA34	3, N	protein	233	SACCHAROMYCES CEREVISIAE	P47006 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA43	4, G, O, V	protein	326	SACCHAROMYCES CEREVISIAE	P46669 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA190	A, P	protein	1664	SACCHAROMYCES CEREVISIAE	P10964
DNA-directed RNA polymerase I subunit RPA135	B, Q	protein	1203	SACCHAROMYCES CEREVISIAE	P22138
DNA-directed RNA polymerases I and III subunit RPAC1	C, R	protein	335	SACCHAROMYCES CEREVISIAE	P07703
DNA-directed RNA polymerase I subunit RPA14	D, S	protein	137	SACCHAROMYCES CEREVISIAE	P50106
DNA-directed RNA polymerases I, II, and III subunit rpabc 1	E, T	protein	215	SACCHAROMYCES CEREVISIAE	P20434
DNA-directed RNA polymerases I, II, and III subunit rpabc 2	F, U	protein	155	SACCHAROMYCES CEREVISIAE	P20435
DNA-directed RNA polymerases I, II, and III subunit rpabc 3	H, W	protein	146	SACCHAROMYCES CEREVISIAE	P20436
DNA-directed RNA polymerase I subunit RPA12	I, X	protein	125	SACCHAROMYCES CEREVISIAE	P32529

2 more molecules are not listed.

Sequence of entity 1 (1, L), FASTA

>4C2M_1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 (chains 1, L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Sequence of entity 2 (2, M), FASTA

>4C2M_2 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 (chains 2, M)
MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERL
EYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTR
PSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDE
ITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNS
KYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILS
RFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKV
VSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Sequence of entity 3 (3, N), FASTA

>4C2M_3 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 (chains 3, N)
MSKLSKDYVSDSDSDDEVISNEFSIPDGFKKCKHLKNFPLNGDNKKKAKQQQVWLIKFPS
NVDISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQDNLSNMTLLVPSESKESLK
IASTAKDNAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDVPKVEGLKLEHFATGYDAEDF
HVAEEVKENKKEPKKRSHHDDEEESSEKKKKKKEKREKREKKDKKDKKKKHRD

Sequence of entity 4 (4, G, O, V), FASTA

>4C2M_4 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 (chains 4, G, O, V)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 5 (A, P), FASTA

>4C2M_5 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 (chains A, P)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 6 (B, Q), FASTA

>4C2M_6 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 (chains B, Q)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 7 (C, R), FASTA

>4C2M_7 DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 (chains C, R)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 8 (D, S), FASTA

>4C2M_8 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 (chains D, S)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 9 (E, T), FASTA

>4C2M_9 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 (chains E, T)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 10 (F, U), FASTA

>4C2M_10 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 (chains F, U)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 11 (H, W), FASTA

>4C2M_11 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 (chains H, W)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 12 (I, X), FASTA

>4C2M_12 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 (chains I, X)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	14

Water and common crystallization additives (SO4) are not listed.

Primary citation

RNA Polymerase I Structure and Transcription Regulation. Engel, C., Sainsbury, S., Cheung, A.C. et al. Nature (2013) 502:502. DOI 10.1038/NATURE12712 · PubMed

Other PDB entries of the same protein (UniProt P40422 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9SV6 1.96 Å, CryoEM structure of transcribing RNA polymerase II elongation complex with ATP and Elf1
9W8V 2.23 Å, Structure of post-translocation state of yeast Pol II complexed with a cisplatin-induced…
9QEB 2.26 Å, CryoEM structure of transcribing RNA polymerase II elongation complex
1TWF 2.3 Å, RNA polymerase II complexed with UTP at 2.3 A resolution
9RYB 2.33 Å, CryoEM structure of transcribing RNA polymerase II elongation complex in post-catalysis…
9KD8 2.46 Å, The structure of RNA polymerase II elongation complex paused at N-2 state by actinomycin…
9K7F 2.5 Å, RNA polymerase II elongation complex apo structure.
30ES 2.54 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…
30EP 2.55 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…
9W8T 2.56 Å, Structure of yeast Pol II in complex with a cisplatin-induced inter-strand crosslink…
7Z0H 2.6 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.6 A (focus subunit AC40).
9W8U 2.61 Å, Structure of pre-translocation state of yeast Pol II complexed with a cisplatin-induced…

Browse structure collections

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