Melanoma differentiation associated protein-5 Helicase domain complex with inhibitor Non-structural protein V. Determined by X-ray diffraction at 2.29 Å resolution. Released 30 Jan 2013.
Explore 4I1S in 3D Show helices and sheets RCSB PDB PDBe
4I1S contains 16 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 548-564 | 17 | |
| α-helix | 571 | 1 | |
| α-helix | 575-590 | 16 | |
| α-helix | 594-615 | 22 | |
| α-helix | 618-636 | 19 | |
| α-helix | 668-689 | 22 | |
| α-helix | 693-695 | 3 | |
| α-helix | 696-712 | 17 | |
| α-helix | 713-715 | 3 | |
| β-strand | 718-722 | 5 | 1 |
| α-helix | 725-736 | 12 | |
| α-helix | 739-743 | 5 | |
| β-strand | 748-751 | 4 | 1 |
| β-strand | 757 | 1 | 2 |
| β-strand | 760 | 1 | 2 |
| α-helix | 765-777 | 13 | |
| β-strand | 782-786 | 5 | 1 |
| α-helix | 790-792 | 3 | |
| β-strand | 800-804 | 5 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 171-180 | 10 | 1 |
| β-strand | 183-192 | 10 | 1 |
| α-helix | 196-197 | 2 | |
| α-helix | 204-206 | 3 | |
| α-helix | 216-218 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Melanoma differentiation associated protein-5 | A | protein | 243 | Sus scrofa | A7LCX1 (AlphaFold model) |
| Non-structural protein V | B | protein | 52 | Simian virus 5 | P11207 (AlphaFold model) |
>4I1S_1 Melanoma differentiation associated protein-5 (chains A) EDLFKDRLLEIMTNIQTFCQISPMSDFGTQPYEQWLIQMEKKAARDGNRKDRVCAEHLKK YNEALQINDTIRRIDAYNHLKTFYNDEKEKKFEVLSGSGSLDESDIFLMTLFLRNKKILK KLAENPEYENEKLTKLRNTIMEHFTRTEESARGIIFTKTRQSAYALSQWITDNKKFAEVG VKAHHLIGAGHSSEFKPMTQNEQREVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYG LVT
>4I1S_2 Non-structural protein V (chains B) GGFHRREYSIGWVGDEVKVTEWCNPSCSPITAAARRFECTCHQCPVTCSECE
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 2 |
Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz, C., Schuhmann, K.M., Kirchhofer, A. et al. Science (2013) 339:690-693. DOI 10.1126/science.1230949 · PubMed
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