4IM3: Tank-Binding Kinase 1

Structure of Tank-Binding Kinase 1. Determined by X-ray diffraction at 3.34 Å resolution. Released 6 Mar 2013.

Method: X-ray diffraction
Resolution: 3.34 Å
Organism: Homo sapiens
Chains: 1
Atoms: 4,923
Mol. weight: 77.81 kDa
Ligands: HG, BX7
Released: 6 Mar 2013

Explore 4IM3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4IM3 contains 25 α-helices and 21 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	1-3	3	1
β-strand	7-10	4	1
β-strand	14-17	4	1
β-strand	21-28	8	1
β-strand	34-40	7	1
α-helix	50-61	12
β-strand	67	1	2
β-strand	70-75	6	1
β-strand	82-86	5	1
β-strand	92-93	2	2
α-helix	94-99	6
α-helix	101-103	3
β-strand	104	1	3
β-strand	106	1	3
α-helix	109-128	20
β-strand	141-145	5	2
β-strand	151-155	5	2
α-helix	201-216	16
β-strand	221-222	2	4
α-helix	231-239	9
α-helix	241-242	2
β-strand	247-250	4	4
β-strand	257-260	4	4
α-helix	271-284	14
α-helix	289-291	3
α-helix	295-306	12
β-strand	309-315	7	5
β-strand	320-326	7	5
α-helix	332-343	12
α-helix	347-349	3
β-strand	351-354	4	5
β-strand	357-358	2	5
α-helix	367-369	3
α-helix	371-372	2
α-helix	378	1
β-strand	379-382	4	5
α-helix	398-402	5
α-helix	408-470	63
α-helix	473-479	7
α-helix	493-526	34
α-helix	536-539	4
α-helix	544-546	3
α-helix	548-571	24
α-helix	577-600	24
α-helix	601-606	6
α-helix	607-644	38

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein kinase TBK1	A	protein	663	Homo sapiens	Q9UHD2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4IM3_1 Serine/threonine-protein kinase TBK1 (chains A)
GSGSGSMQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR
EFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI
VLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY
GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM
YKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG
FDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIY
EGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASM
AKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRN
IEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLAD
AWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHA
TKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNEL
QET

Ligands and cofactors

ID	Name	Formula	Copies
HG	Mercury (II) ion	Hg	5
BX7	N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]a…	C23 H26 I N7 O2 S	1

Water and common crystallization additives (CL) are not listed.

Primary citation

Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Tu, D., Zhu, Z., Zhou, A.Y. et al. Cell Rep (2013) 3:747-758. DOI 10.1016/j.celrep.2013.01.033 · PubMed

Other PDB entries of the same protein (UniProt Q9UHD2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5EP6 1.45 Å, The crystal structure of NAP1 in complex with TBK1
4EFO 1.77 Å, Crystal structure of the ubiquitin-like domain of human TBK1
4EUU 1.8 Å, Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172
5EOF 2.05 Å, Crystal structure of OPTN NTD and TBK1 CTD complex
4IM0 2.4 Å, Structure of Tank-Binding Kinase 1
4IM2 2.5 Å, Structure of Tank-Binding Kinase 1
5EOA 2.5 Å, Crystal structure of OPTN E50K mutant and TBK1 complex
4EUT 2.6 Å, Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain
4IWO 2.61 Å, Crystal structure and mechanism of activation of TBK1
6RSU 2.75 Å, TBK1 in complex with Inhibitor compound 35
4IWQ 3.0 Å, Crystal structure and mechanism of activation of TBK1
4IWP 3.06 Å, Crystal structure and mechanism of activation of TBK1

Browse structure collections

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