4KS8: PAK6 kinase domain

PAK6 kinase domain in complex with sunitinib. Determined by X-ray diffraction at 1.95 Å resolution. Released 11 Sept 2013.

Method: X-ray diffraction
Resolution: 1.95 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,496
Mol. weight: 33.7 kDa
Ligands: B49
Released: 11 Sept 2013

Explore 4KS8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4KS8 contains 22 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	387-395	9
α-helix	399	1
α-helix	404-406	3
β-strand	407-414	8	1
β-strand	420-426	7	1
β-strand	432-439	8	1
α-helix	446-450	5
α-helix	451-458	8
β-strand	464	1	2
α-helix	465-466	2
β-strand	467-473	7	1
β-strand	476-482	7	1
β-strand	487-488	2	2
α-helix	489-493	5
α-helix	497-499	3
α-helix	500-519	20
β-strand	522-523	2	3
α-helix	529-531	3
β-strand	532-534	3	2
β-strand	540-542	3	2
α-helix	545-547	3
β-strand	549-550	2	3
β-strand	558	1	4
α-helix	565-567	3
α-helix	570-573	4
β-strand	578	1	4
α-helix	582-596	15
α-helix	606-615	10
α-helix	618-621	4
α-helix	624-626	3
α-helix	629-636	8
α-helix	647-648	2
α-helix	649-653	5
α-helix	656-660	5
α-helix	664-670	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein kinase PAK 6	A	protein	292	Homo sapiens	Q9NQU5 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4KS8_1 Serine/threonine-protein kinase PAK 6 (chains A)
GSVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRK
QQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQ
IATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLV
GTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLK
NSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLY

Ligands and cofactors

ID	Name	Formula	Copies
B49	N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene…	C22 H27 F N4 O2	1

Primary citation

Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6. Gao, J., Ha, B.H., Lou, H.J. et al. PLoS One (2013) 8:e77818-e77818. DOI 10.1371/journal.pone.0077818 · PubMed

Other PDB entries of the same protein (UniProt Q9NQU5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4KS7 1.4 Å, PAK6 kinase domain in complex with PF-3758309
2C30 1.6 Å, Crystal Structure Of The Human P21-Activated Kinase 6
6QDR 1.61 Å, Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide
6QDS 1.72 Å, Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide stabilized…
2ODB 2.4 Å, The crystal structure of human cdc42 in complex with the CRIB domain of human…

Browse structure collections

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