4LFH: 9C2 TCR

Crystal Structure of 9C2 TCR. Determined by X-ray diffraction at 2.3 Å resolution. Released 2 Oct 2013.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,670
Mol. weight: 55.47 kDa
Released: 2 Oct 2013

Explore 4LFH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4LFH contains 18 α-helices and 40 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain D: 6 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	6-8	3	1
β-strand	13-17	5	2
β-strand	22-24	3	1
β-strand	27-29	3	1
β-strand	36-42	7	2
β-strand	48-55	8	2
β-strand	62-63	2	1
β-strand	66-71	6	1
β-strand	76-81	6	1
α-helix	86-88	3
β-strand	90-97	8	2
β-strand	107-109	3	2
β-strand	113-118	6	2
α-helix	119-121	3
β-strand	125	1	3
α-helix	126-127	2
β-strand	128-134	7	4
β-strand	137-145	9	4
β-strand	146	1	3
β-strand	151-155	5	5
β-strand	159-162	4	4
α-helix	164-165	2
β-strand	166-169	4	4
β-strand	175-183	9	4
α-helix	186-188	3
β-strand	190-195	6	5
β-strand	198-201	4	5
α-helix	202-205	4

Chain G: 12 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	12-16	5	6
β-strand	22-25	4	7
β-strand	35-41	7	6
β-strand	48-54	7	6
β-strand	59-62	4	6
α-helix	63	1
α-helix	66-67	2
β-strand	71-77	7	7
β-strand	80-85	6	7
α-helix	90-92	3
β-strand	94-101	8	6
β-strand	113-115	3	6
β-strand	119-123	5	6
α-helix	134	1
β-strand	135-139	5	8
α-helix	140-142	3
α-helix	143-149	7
β-strand	151-161	11	8
β-strand	167-172	6	9
α-helix	177-179	3
β-strand	182-183	2	8
α-helix	184-186	3
β-strand	187-189	3	8
β-strand	192-202	11	8
α-helix	203-205	3
β-strand	210-215	6	9
α-helix	220-222	3
α-helix	223-224	2
β-strand	225-229	5	9
α-helix	230-232	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
9C2 TCR delta chain	D	protein	236	Homo sapiens	Q6PJ56 (AlphaFold model)
9C2 TCR gamma chain	G	protein	251	Homo sapiens	P0CF51 (AlphaFold model)

Sequence of entity 1 (D), FASTA

>4LFH_1 9C2 TCR delta chain (chains D)
ETGAQKVTQAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYKQLPSKEMIFLIRQGSDEQN
AKSGRYSVNFKKAAKSVALTISALQLEDSAKYFCALGDPGGLNTDKLIFGKGTRVTVEPR
SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKL
GKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSASGLVPR

Sequence of entity 2 (G), FASTA

>4LFH_2 9C2 TCR gamma chain (chains G)
ETGSSNLEGGTKSVTRPTRSSAEITCDLTVINAFYIHWYLHQEGKAPQRLLYYDVSNSKD
VLESGLSPGKYYTHTPRRWSWILILRNLIENDSGVYYCATWDRGNPKTHYYKKLFGSGTT
LVVTDKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILG
SQEGNTMKTNDTYMKFSWLTVPEESLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMD
PKDNASGLVPR

Primary citation

CD1d-lipid antigen recognition by the gamma delta TCR. Uldrich, A.P., Le Nours, J., Pellicci, D.G. et al. Nat Immunol (2013) 14:1137-1145. DOI 10.1038/ni.2713 · PubMed

Other PDB entries of the same protein (UniProt Q6PJ56 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6D7G 2.75 Å, Structure of 5F3 TCR in complex with HLA-A2/MART-1
4LHU 2.87 Å, Crystal Structure of 9C2 TCR bound to CD1d
8ZD4 2.9 Å, Cryo-EM structure of the gdTCR-ECD
4MNG 3.01 Å, Structure of the DP10.7 TCR with CD1d-sulfatide
4NDM 3.01 Å, Structure of the AB18.1 TCR
9LSY 3.23 Å, Structure of the gdTCR-Fab complex
4MNH 3.3 Å, Structure of the DP10.7 TCR
8ZA6 3.43 Å, Cryo-EM structure of the gdTCR-CD3 complex

Browse structure collections

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