T cell receptor gamma constant 1 (TRGC1) is a 173-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0CF51.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs)…
Gamma-delta TR is a heterodimer composed of a gamma and delta chain; disulfide-linked. The gamma-delta TR is associated with the transmembrane signaling CD3 coreceptor proteins following the stoichiometry: a single gamma-delta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. Upon activation,…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4LFH | X-ray | 2.3 Å | G=1-122 |
| 4LHU | X-ray | 2.87 Å | G=1-122 |
| 9CI8 | EM | 3.01 Å | n=128-165 |
| 8JBV | EM | 3.02 Å | N/n=1-173 |
| 9JY1 | EM | 3.08 Å | N/n=1-173 |
| 9JY2 | EM | 3.24 Å | n=127-164 |
| 9JY4 | EM | 3.29 Å | N/n=1-173 |
| 9JXZ | EM | 3.31 Å | n=1-173 |
| 9JY3 | EM | 3.35 Å | N/n=127-164 |
| 9CIA | EM | 3.39 Å | n=128-163 |
| 8JC0 | EM | 3.4 Å | n=1-173 |
| 9JY0 | EM | 3.69 Å | n=1-173 |
| 8WY0 | EM | 3.8 Å | n=1-173 |
| 8WYI | EM | 3.9 Å | n=1-173 |
| 9J5M | EM | 3.94 Å | B/I=1-109 |
| 8WXE | EM | 4.0 Å | n=1-173 |
| 9J5J | EM | 4.05 Å | B/I=1-109 |
| 8YC0 | EM | 4.12 Å | n=1-173 |
| 8JCB | EM | 9.5 Å | N/n=1-173 |
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