Crystal structure of mouse calcineurin. Determined by X-ray diffraction at 3.11 Å resolution. Released 20 May 2015.
Explore 4ORB in 3D Show helices and sheets RCSB PDB PDBe
4ORB contains 34 α-helices and 29 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 22-24 | 3 | |
| β-strand | 28-29 | 2 | 1 |
| α-helix | 31-34 | 4 | |
| β-strand | 35 | 1 | 2 |
| β-strand | 41 | 1 | 2 |
| α-helix | 43-51 | 9 | |
| β-strand | 55-56 | 2 | 1 |
| α-helix | 58-72 | 15 | |
| β-strand | 78-81 | 4 | 3 |
| α-helix | 82 | 1 | |
| β-strand | 85-88 | 4 | 4 |
| β-strand | 90 | 1 | 5 |
| α-helix | 95-105 | 11 | |
| β-strand | 113-115 | 3 | 4 |
| α-helix | 126-139 | 14 | |
| β-strand | 144-146 | 3 | 4 |
| α-helix | 154-159 | 6 | |
| α-helix | 161-169 | 9 | |
| α-helix | 172-182 | 11 | |
| β-strand | 188-191 | 4 | 3 |
| β-strand | 195-198 | 4 | 3 |
| α-helix | 209-213 | 5 | |
| α-helix | 221-222 | 2 | |
| α-helix | 226-232 | 7 | |
| β-strand | 234-235 | 2 | 6 |
| β-strand | 248-250 | 3 | 6 |
| β-strand | 258-260 | 3 | 6 |
| α-helix | 262-271 | 10 | |
| β-strand | 276-279 | 4 | 3 |
| β-strand | 286-287 | 2 | 4 |
| β-strand | 288-290 | 3 | 3 |
| α-helix | 292 | 1 | |
| β-strand | 293 | 1 | 7 |
| α-helix | 294 | 1 | |
| β-strand | 300 | 1 | 7 |
| β-strand | 302-305 | 4 | 3 |
| β-strand | 306 | 1 | 5 |
| α-helix | 311-313 | 3 | |
| β-strand | 318-325 | 8 | 4 |
| β-strand | 328-334 | 7 | 4 |
| α-helix | 344-346 | 3 | |
| α-helix | 349-369 | 21 | |
| α-helix | 460-466 | 7 | |
| α-helix | 468-471 | 4 | |
| α-helix | 473-474 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 16-29 | 14 | |
| β-strand | 36 | 1 | 8 |
| α-helix | 39-43 | 5 | |
| α-helix | 47-50 | 4 | |
| α-helix | 54-61 | 8 | |
| β-strand | 70 | 1 | 8 |
| α-helix | 71-79 | 9 | |
| β-strand | 82 | 1 | 9 |
| α-helix | 87-98 | 12 | |
| β-strand | 106 | 1 | 10 |
| α-helix | 108-119 | 12 | |
| α-helix | 120-122 | 3 | |
| α-helix | 125-139 | 15 | |
| β-strand | 147 | 1 | 10 |
| α-helix | 149-156 | 8 | |
| α-helix | 157-159 | 3 | |
| α-helix | 161-164 | 4 | |
| β-strand | 167 | 1 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | A | protein | 519 | Mus musculus | P63328 (AlphaFold model) |
| Calcineurin subunit B type 1 | B | protein | 170 | Mus musculus | Q63810 (AlphaFold model) |
>4ORB_1 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (chains A) MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG NEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV LTLKGLTPTGMLPSGVLSGGKQTLQSAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAM PSDANLNSINKALASETNGTDSNGSNSSNIQLEHHHHHH
>4ORB_2 Calcineurin subunit B type 1 (chains B) MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVID IFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMV GNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Li, S.J., Ma, L., Wang, J. et al. To be published.
Other PDB entries of the same protein (UniProt P63328 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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