4OY2: TAF1-TAF7, a TFIID subcomplex
Crystal structure of TAF1-TAF7, a TFIID subcomplex. Determined by X-ray diffraction at 2.9 Å resolution. Released 25 Jun 2014.
- Method
- X-ray diffraction
- Resolution
- 2.9 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 6
- Atoms
- 16,474
- Mol. weight
- 258.64 kDa
- Ligands
- ZN
- Released
- 25 Jun 2014
Explore 4OY2 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
4OY2 contains 109 α-helices and 86 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 25 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 471-475 | 5 | |
| β-strand | 482 | 1 | 1 |
| α-helix | 488-491 | 4 | |
| β-strand | 507-510 | 4 | 2 |
| α-helix | 511-513 | 3 | |
| β-strand | 514 | 1 | 3 |
| α-helix | 515 | 1 | |
| α-helix | 518-521 | 4 | |
| α-helix | 526-529 | 4 | |
| α-helix | 533-536 | 4 | |
| β-strand | 540 | 1 | 3 |
| β-strand | 544-549 | 6 | 2 |
| β-strand | 563-571 | 9 | 2 |
| β-strand | 587-591 | 5 | 2 |
| α-helix | 592 | 1 | |
| α-helix | 595-597 | 3 | |
| β-strand | 607 | 1 | 2 |
| β-strand | 610-615 | 6 | 2 |
| β-strand | 619-626 | 8 | 2 |
| α-helix | 627-629 | 3 | |
| β-strand | 632-640 | 9 | 2 |
| β-strand | 643-650 | 8 | 2 |
| β-strand | 654-658 | 5 | 2 |
| α-helix | 660-661 | 2 | |
| β-strand | 662-663 | 2 | 2 |
| α-helix | 666-668 | 3 | |
| α-helix | 673-694 | 22 | |
| β-strand | 699 | 1 | 4 |
| α-helix | 702-705 | 4 | |
| α-helix | 713-720 | 8 | |
| β-strand | 724-726 | 3 | 4 |
| β-strand | 736-738 | 3 | 4 |
| α-helix | 743-744 | 2 | |
| α-helix | 747-750 | 4 | |
| α-helix | 751-753 | 3 | |
| α-helix | 756-778 | 23 | |
| α-helix | 782-790 | 9 | |
| α-helix | 793-804 | 12 | |
| β-strand | 809-810 | 2 | 5 |
| β-strand | 829-830 | 2 | 5 |
| α-helix | 859-882 | 24 | |
| α-helix | 888-891 | 4 | |
| α-helix | 900-903 | 4 | |
| β-strand | 914-922 | 9 | 6 |
| β-strand | 928-935 | 8 | 6 |
| α-helix | 938-951 | 14 | |
Chain B: 11 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-94 | 5 | |
| β-strand | 98 | 1 | 1 |
| β-strand | 112-119 | 8 | 2 |
| α-helix | 126-135 | 10 | |
| β-strand | 141-145 | 5 | 2 |
| β-strand | 150-155 | 6 | 2 |
| β-strand | 158-175 | 18 | 2 |
| β-strand | 181-197 | 17 | 2 |
| α-helix | 201-204 | 4 | |
| β-strand | 212-213 | 2 | 2 |
| α-helix | 221-223 | 3 | |
| α-helix | 224-234 | 11 | |
| α-helix | 238-240 | 3 | |
| α-helix | 241-244 | 4 | |
| α-helix | 245-249 | 5 | |
| α-helix | 251-256 | 6 | |
| β-strand | 260-261 | 2 | 2 |
| α-helix | 267-269 | 3 | |
| α-helix | 283-301 | 19 | |
| β-strand | 305-311 | 7 | 6 |
Chain C: 26 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 471-474 | 4 | |
| β-strand | 482 | 1 | 7 |
| α-helix | 487-491 | 5 | |
| α-helix | 499-501 | 3 | |
| β-strand | 507-508 | 2 | 8 |
| α-helix | 511-513 | 3 | |
| α-helix | 518-521 | 4 | |
| α-helix | 526-529 | 4 | |
| α-helix | 533-535 | 3 | |
| β-strand | 544-549 | 6 | 8 |
| β-strand | 563-571 | 9 | 8 |
| β-strand | 587-591 | 5 | 8 |
| α-helix | 592 | 1 | |
| α-helix | 595-597 | 3 | |
| α-helix | 600-602 | 3 | |
| β-strand | 607 | 1 | 8 |
| β-strand | 610-615 | 6 | 8 |
| β-strand | 619-626 | 8 | 8 |
| α-helix | 627-629 | 3 | |
| β-strand | 632-639 | 8 | 8 |
| β-strand | 646-650 | 5 | 8 |
| β-strand | 654-658 | 5 | 8 |
| β-strand | 662-663 | 2 | 8 |
| α-helix | 666-668 | 3 | |
| α-helix | 673-676 | 4 | |
| α-helix | 678-694 | 17 | |
| α-helix | 705-707 | 3 | |
| α-helix | 717-720 | 4 | |
| β-strand | 724-725 | 2 | 9 |
| β-strand | 737-738 | 2 | 9 |
| α-helix | 747-750 | 4 | |
| α-helix | 751-753 | 3 | |
| α-helix | 756-778 | 23 | |
| α-helix | 782-790 | 9 | |
| α-helix | 793-804 | 12 | |
| β-strand | 809-812 | 4 | 10 |
| β-strand | 826-830 | 5 | 10 |
| α-helix | 861-882 | 22 | |
| α-helix | 888-891 | 4 | |
| α-helix | 900-903 | 4 | |
| β-strand | 915-922 | 8 | 11 |
| α-helix | 923 | 1 | |
| β-strand | 928-935 | 8 | 11 |
| α-helix | 938-953 | 16 | |
Chain D: 9 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 98 | 1 | 7 |
| β-strand | 112-119 | 8 | 8 |
| α-helix | 124-135 | 12 | |
| β-strand | 141-147 | 7 | 8 |
| β-strand | 150-155 | 6 | 8 |
| β-strand | 159-175 | 17 | 8 |
| β-strand | 181-197 | 17 | 8 |
| α-helix | 201-206 | 6 | |
| β-strand | 212-213 | 2 | 8 |
| α-helix | 224-234 | 11 | |
| α-helix | 238-240 | 3 | |
| α-helix | 245-249 | 5 | |
| α-helix | 251-254 | 4 | |
| β-strand | 260-261 | 2 | 8 |
| α-helix | 267-269 | 3 | |
| α-helix | 272-275 | 4 | |
| α-helix | 283-301 | 19 | |
| β-strand | 307-310 | 4 | 11 |
Chain E: 26 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 471-474 | 4 | |
| β-strand | 482 | 1 | 12 |
| α-helix | 487-491 | 5 | |
| α-helix | 498-500 | 3 | |
| α-helix | 506 | 1 | |
| β-strand | 507-508 | 2 | 13 |
| β-strand | 510 | 1 | 13 |
| α-helix | 512-515 | 4 | |
| α-helix | 518-521 | 4 | |
| α-helix | 526-529 | 4 | |
| α-helix | 533-536 | 4 | |
| β-strand | 544-549 | 6 | 13 |
| β-strand | 563-571 | 9 | 13 |
| β-strand | 587-591 | 5 | 13 |
| α-helix | 596-597 | 2 | |
| β-strand | 607 | 1 | 13 |
| β-strand | 610-615 | 6 | 13 |
| β-strand | 620-626 | 7 | 13 |
| α-helix | 627-629 | 3 | |
| β-strand | 632-640 | 9 | 13 |
| β-strand | 643-650 | 8 | 13 |
| β-strand | 654-658 | 5 | 13 |
| α-helix | 660-661 | 2 | |
| β-strand | 662 | 1 | 13 |
| α-helix | 663 | 1 | |
| α-helix | 666-669 | 4 | |
| α-helix | 673-693 | 21 | |
| β-strand | 698-699 | 2 | 14 |
| α-helix | 702-704 | 3 | |
| α-helix | 713-720 | 8 | |
| β-strand | 724-726 | 3 | 14 |
| β-strand | 736-738 | 3 | 14 |
| α-helix | 747-750 | 4 | |
| α-helix | 751-753 | 3 | |
| α-helix | 756-778 | 23 | |
| α-helix | 782-790 | 9 | |
| α-helix | 793-805 | 13 | |
| β-strand | 810-812 | 3 | 15 |
| β-strand | 826-829 | 4 | 15 |
| α-helix | 830 | 1 | |
| α-helix | 861-882 | 22 | |
| α-helix | 888-891 | 4 | |
| α-helix | 900-903 | 4 | |
| β-strand | 914-922 | 9 | 16 |
| β-strand | 928-935 | 8 | 16 |
| α-helix | 938-952 | 15 | |
Chain F: 12 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 95-97 | 3 | |
| β-strand | 98 | 1 | 12 |
| β-strand | 112-119 | 8 | 13 |
| α-helix | 124-135 | 12 | |
| β-strand | 141-145 | 5 | 13 |
| β-strand | 150-155 | 6 | 13 |
| β-strand | 158-175 | 18 | 13 |
| β-strand | 181-198 | 18 | 13 |
| α-helix | 201-206 | 6 | |
| β-strand | 212-213 | 2 | 13 |
| α-helix | 221-223 | 3 | |
| α-helix | 224-234 | 11 | |
| α-helix | 238-240 | 3 | |
| α-helix | 241-244 | 4 | |
| α-helix | 245-249 | 5 | |
| α-helix | 251-256 | 6 | |
| β-strand | 260-261 | 2 | 13 |
| α-helix | 267-269 | 3 | |
| α-helix | 272-275 | 4 | |
| α-helix | 283-300 | 18 | |
| β-strand | 305-311 | 7 | 16 |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Transcription initiation factor TFIID subunit 1 | A, C, E | protein | 506 | Saccharomyces cerevisiae | P46677 (AlphaFold model) |
| Transcription initiation factor TFIID subunit 7 | B, D, F | protein | 235 | Saccharomyces cerevisiae | Q05021 (AlphaFold model) |
Sequence of entity 1 (A, C, E), FASTA
>4OY2_1 Transcription initiation factor TFIID subunit 1 (chains A, C, E)
QTKVRSTISNLNIQHSQPAINLQSPFYKVAVPRYQLRHFHRENFGSHIRPGTKIVFSKLK
ARKRKRDKGKDVKESFSTSQDLTIGDTAPVYLMEYSEQTPVALSKFGMANKLINYYRKAN
EQDTLRPKLPVGETHVLGVQDKSPFWNFGFVEPGHIVPTLYNNMIRAPVFKHDISGTDFL
LTKSSGFGISNRFYLRNINHLFTVGQTFPVEEIPGPNSRKVTSMKATRLKMIIYRILNHN
HSKAISIDPIAKHFPDQDYGQNRQKVKEFMKYQRDGPEKGLWRLKDDEKLLDNEAVKSLI
TPEQISQVESMSQGLQFQEDNEAYNFDSKLKSLEENLLPWNITKNFINSTQMRAMIQIHG
VGDPTGCGEGFSFLKTSMKGGFVKSGSPSSNNNSSNKKGTNTHSYNVAQQQKAYDEEIAK
TWYTHTKSLSISNPFEEMTNPDEINQTNKHVKTDRDDKKILKIVRKKRDENGIIQRQTIF
IRDPRVIQGYIKIKEQDKEDVNKLLE
Sequence of entity 2 (B, D, F), FASTA
>4OY2_2 Transcription initiation factor TFIID subunit 7 (chains B, D, F)
KLRLKPIRIPGEAYDSEASDIEDDPLIESGVILRILPDIQLEFVKNSLESGDYSGISIKW
KNERHAVVTINDVMYGAILVDLPTVIEVNKSVDRKNLLKTFDVSQMLLCIRPIQEEEEVY
ALEAPDTEDLVVKHFEGIEDEIWENKETFLKGYNGAPLSDMEAKHLKEIALKGYDYKHGI
SPPLYNVRNRRFRRKMDPNEIDYVEKVVDMLLKQDKQAEEVSYDLVDKSELQARQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 1 |
Water and common crystallization additives (TRS) are not listed.
Primary citation
Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Bhattacharya, S., Lou, X., Hwang, P. et al. Proc Natl Acad Sci U S A (2014) 111:9103-9108. DOI 10.1073/pnas.1408293111 · PubMed
Other PDB entries of the same protein (UniProt P46677 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4B0A 1.97 Å, The high-resolution structure of yTBP-yTAF1 identifies conserved and competing…
- 6E16 2.4 Å, Ternary structure of c-Myc-TBP-TAF1
- 6E24 3.0 Å, Ternary structure of c-Myc-TBP-TAF1
Browse structure collections
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