Crystal Structure of a TAF1-TAF7 Complex in Human Transcription Factor IID. Determined by X-ray diffraction at 2.3 Å resolution. Released 3 Dec 2014.
Explore 4RGW in 3D Show helices and sheets RCSB PDB PDBe
4RGW contains 28 α-helices and 21 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 614-617 | 4 | |
| α-helix | 630-634 | 5 | |
| α-helix | 639-641 | 3 | |
| α-helix | 648-650 | 3 | |
| β-strand | 655-659 | 5 | 1 |
| α-helix | 661-676 | 16 | |
| α-helix | 689-692 | 4 | |
| β-strand | 698-704 | 7 | 1 |
| α-helix | 713-714 | 2 | |
| β-strand | 718-725 | 8 | 1 |
| α-helix | 727-728 | 2 | |
| α-helix | 735-737 | 3 | |
| β-strand | 742-745 | 4 | 1 |
| α-helix | 754-756 | 3 | |
| β-strand | 760-765 | 6 | 1 |
| β-strand | 769-777 | 9 | 1 |
| α-helix | 778-779 | 2 | |
| β-strand | 782-788 | 7 | 1 |
| β-strand | 791-795 | 5 | 1 |
| β-strand | 799-803 | 5 | 1 |
| β-strand | 807-808 | 2 | 1 |
| α-helix | 811-814 | 4 | |
| α-helix | 818-838 | 21 | |
| β-strand | 845-847 | 3 | 2 |
| α-helix | 848-854 | 7 | |
| α-helix | 860-868 | 9 | |
| β-strand | 871-874 | 4 | 2 |
| β-strand | 882-885 | 4 | 2 |
| α-helix | 889-893 | 5 | |
| α-helix | 894-900 | 7 | |
| α-helix | 903-921 | 19 | |
| α-helix | 926-928 | 3 | |
| α-helix | 946-949 | 4 | |
| α-helix | 952-963 | 12 | |
| β-strand | 968-971 | 4 | 3 |
| β-strand | 985-989 | 5 | 3 |
| α-helix | 1076-1099 | 24 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 12-13 | 2 | |
| β-strand | 14-19 | 6 | 1 |
| α-helix | 22-34 | 13 | |
| α-helix | 39-42 | 4 | |
| β-strand | 43-47 | 5 | 1 |
| β-strand | 53-58 | 6 | 1 |
| β-strand | 61-79 | 19 | 1 |
| β-strand | 84-98 | 15 | 1 |
| β-strand | 131 | 1 | 1 |
| α-helix | 138-140 | 3 | |
| α-helix | 143-146 | 4 | |
| α-helix | 149-153 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transcription initiation factor TFIID subunit 1 | A | protein | 638 | Homo sapiens | P21675 (AlphaFold model) |
| Transcription initiation factor TFIID subunit 7 | B | protein | 350 | Homo sapiens | Q15545 (AlphaFold model) |
>4RGW_1 Transcription initiation factor TFIID subunit 1 (chains A) SGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQ PLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMA TKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKM PETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWK SKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIR AMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRA FIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRR LSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAE HQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQL SREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGK EYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQ
>4RGW_2 Transcription initiation factor TFIID subunit 7 (chains B) SMSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVD RVPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKAS KKKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVST RWEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQ DEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRA KRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK
Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Wang, H., Curran, E.C., Hinds, T.R. et al. Cell Res (2014) 24:1433-1444. DOI 10.1038/cr.2014.148 · PubMed
Other PDB entries of the same protein (UniProt P21675 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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