4ROW: DNA dC->dU-editing enzyme APOBEC-3G

The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA. Determined by X-ray diffraction at 1.7 Å resolution. Released 31 Dec 2014.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,782
Mol. weight: 23.25 kDa
Ligands: ZN
Released: 31 Dec 2014

Explore 4ROW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4ROW contains 13 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	194	1	1
β-strand	197	1	2
α-helix	199-206	8
β-strand	219-228	10	1
β-strand	231-234	4	1
α-helix	236-238	3
β-strand	240-243	4	1
α-helix	244	1
β-strand	245	1	3
α-helix	246-247	2
β-strand	256	1	3
α-helix	258-265	8
α-helix	266-269	4
β-strand	277-283	7	1
α-helix	286-288	3
α-helix	289-301	13
β-strand	305-311	7	1
α-helix	321-330	10
β-strand	334-337	4	1
α-helix	340-350	11
β-strand	351	1	2
α-helix	356-358	3
α-helix	360-361	2
α-helix	364-379	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA dC->dU-editing enzyme APOBEC-3G	A	protein	198	Homo sapiens	Q9HC16 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4ROW_1 DNA dC->dU-editing enzyme APOBEC-3G (chains A)
GSHMASLRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQA
PHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVS
LCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDE
HSQALSGRLRAILQNQEN

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA. Lu, X., Zhang, T., Xu, Z. et al. J Biol Chem (2015) 290:4010-4021. DOI 10.1074/jbc.M114.624262 · PubMed

Other PDB entries of the same protein (UniProt Q9HC16 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3V4K 1.38 Å, First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase…
7UXD 1.5 Å, Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy…
4ROV 1.8 Å, The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode…
6BUX 1.86 Å, Crystal structure of APOBEC3G catalytic domain complex with substrate ssDNA
5ZVB 2.0 Å, APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dT9)
3V4J 2.04 Å, First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase…
3IR2 2.25 Å, Crystal structure of the APOBEC3G catalytic domain
3E1U 2.3 Å, The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain
3IQS 2.3 Å, Crystal structure of the anti-viral APOBEC3G catalytic domain
5ZVA 2.3 Å, APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dC9)
8J62 2.5 Å, Cryo-EM structure of APOBEC3G-Vif complex
8CX0 2.7 Å, Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex

Browse structure collections

About this viewer

MolViewer shows 4ROW directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.