4V6M: Cell division protein FtsQ

Structure of the ribosome-SecYE complex in the membrane environment. Determined by electron microscopy at 7.1 Å resolution. Released 9 Jul 2014.

Method
Electron microscopy
Resolution
7.1 Å
Organisms
Escherichia coli, Escherichia coli DH1, Escherichia coli O157:H7
Chains
60
Atoms
163,040
Mol. weight
2410.93 kDa
Ligands
PGV, PEV
Released
9 Jul 2014

Explore 4V6M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4V6M contains 272 α-helices and 303 β-strands across 55 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A0: 14 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix51-9747
α-helix98-1003
α-helix103-11917
α-helix122-14120
α-helix142-1454
α-helix151-1533
α-helix154-1585
α-helix1591
α-helix164-1674
α-helix174-1763
α-helix179-19416
α-helix198-2058
α-helix209-2113
α-helix213-22412
Chain A1: 15 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix51-6212
α-helix65-695
α-helix75-11945
α-helix121-13010
α-helix138-1403
α-helix144-1496
α-helix150-1534
α-helix156-1583
α-helix160-1623
α-helix167-1759
α-helix181-19313
α-helix195-20511
α-helix209-21810
α-helix220-2234
β-strand226114
β-strand228114
α-helix240-2412
Chain AB: 13 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix2-109
β-strand30-31222
β-strand39-40222
α-helix45-517
β-strand66-67223
α-helix76-794
α-helix80-823
β-strand88-89223
α-helix103-1064
α-helix108-11912
α-helix130-14112
α-helix144-1474
α-helix148-1503
β-strand160-161224
α-helix171-1744
α-helix180-1812
β-strand182-183224
α-helix209-2124
α-helix225-23915
Chain AC: 6 helices, 10 β-strands
ElementResiduesLengthSheet
β-strand20-21230
α-helix28-4518
β-strand51-58830
β-strand63-69730
α-helix72-754
α-helix81-9313
β-strand98-100330
α-helix112-12312
α-helix130-14213
β-strand148-152531
α-helix156-1583
β-strand165-169531
β-strand181132
β-strand184-188531
β-strand195-201731
β-strand202132
Chain AD: 10 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix7-126
α-helix49-6113
α-helix68-7811
α-helix85-928
β-strand96137
α-helix97-1026
α-helix110-1189
β-strand122-124338
β-strand127-128238
β-strand135137
β-strand142-144338
α-helix146-1483
α-helix152-1587
α-helix160-1623
β-strand178-179238
α-helix196-2049
Chain AE: 8 helices, 6 β-strands
ElementResiduesLengthSheet
β-strand11-231341
β-strand28-391241
β-strand45142
α-helix57-648
β-strand71142
β-strand92-96543
α-helix109-1113
α-helix113-1164
β-strand123-127543
α-helix132-1354
α-helix136-1383
α-helix139-1446
α-helix149-1524
α-helix155-16511
Chain AF: 6 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand2-8750
α-helix15-173
α-helix18-3013
β-strand35-43950
α-helix45-473
β-strand59-66850
α-helix68-7811
β-strand87-91550
α-helix101-11111
α-helix118-12912
Chain AG: 10 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix5-73
α-helix12-143
α-helix24-285
β-strand31155
β-strand34155
α-helix35-5218
α-helix62-654
β-strand72-74356
β-strand87-89356
α-helix90-912
α-helix92-10514
α-helix116-1249
α-helix137-14610
α-helix154-16411

47 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
16S ribosomal RNAAARNA1542Escherichia coli
mRNAAXRNA11Escherichia coli
FtsQ nascent chainAVRNA77Escherichia coli DH1
Cell division protein FtsQAZprotein98Escherichia coli O157:H7Q8X9Y5 (AlphaFold model)
Apolipoprotein A-IA0, A1protein200Homo sapiensP02647 (AlphaFold model)
30S ribosomal protein S2ABprotein240Escherichia coli K-12P0A7V0 (AlphaFold model)
30S ribosomal protein S3ACprotein232Escherichia coli K-12P0A7V3 (AlphaFold model)
30S ribosomal protein S4ADprotein205Escherichia coli K-12P0A7V8
30S ribosomal protein S5AEprotein166Escherichia coli K-12P0A7W1
30S ribosomal protein S6AFprotein135Escherichia coli K-12P02358
30S ribosomal protein S7AGprotein178Escherichia coli K-12P02359
30S ribosomal protein S8AHprotein129Escherichia coli K-12P0A7W7

47 more molecules are not listed.

Sequence of entity 1 (AA), FASTA
>4V6M_1 16S RIBOSOMAL RNA (chains AA)
AAAUUGAAGAGUUUGAUCAUGGCUCAGAUUGAACGCUGGCGGCAGGCCUAACACAUGCAA
GUCGAACGGUAACAGGAAGAAGCUUGCUUCUUUGCUGACGAGUGGCGGACGGGUGAGUAA
UGUCUGGGAAACUGCCUGAUGGAGGGGGAUAACUACUGGAAACGGUAGCUAAUACCGCAU
AACGUCGCAAGACCAAAGAGGGGGACCUUCGGGCCUCUUGCCAUCGGAUGUGCCCAGAUG
GGAUUAGCUAGUAGGUGGGGUAACGGCUCACCUAGGCGACGAUCCCUAGCUGGUCUGAGA
GGAUGACCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGGGAGGCAGCAGUGG
GGAAUAUUGCACAAUGGGCGCAAGCCUGAUGCAGCCAUGCCGCGUGUAUGAAGAAGGCCU
UCGGGUUGUAAAGUACUUUCAGCGGGGAGGAAGGGAGUAAAGUUAAUACCUUUGCUCAUU
GACGUUACCCGCAGAAGAAGCACCGGCUAACUCCGUGCCAGCAGCCGCGGUAAUACGGAG
GGUGCAAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGCACGCAGGCGGUUUGUUAAGUCA
GAUGUGAAAUCCCCGGGCUCAACCUGGGAACUGCAUCUGAUACUGGCAAGCUUGAGUCUC
GUAGAGGGGGGUAGAAUUCCAGGUGUAGCGGUGAAAUGCGUAGAGAUCUGGAGGAAUACC
GGUGGCGAAGGCGGCCCCCUGGACGAAGACUGACGCUCAGGUGCGAAAGCGUGGGGAGCA
AACAGGAUUAGAUACCCUGGUAGUCCACGCCGUAAACGAUGUCGACUUGGAGGUUGUGCC
CUUGAGGCGUGGCUUCCGGAGCUAACGCGUUAAGUCGACCGCCUGGGGAGUACGGCCGCA
AGGUUAAAACUCAAAUGAAUUGACGGGGGCCCGCACAAGCGGUGGAGCAUGUGGUUUAAU
UCGAUGCAACGCGAAGAACCUUACCUGGUCUUGACAUCCACGGAAGUUUUCAGAGAUGAG
AAUGUGCCUUCGGGAACCGUGAGACAGGUGCUGCAUGGCUGUCGUCAGCUCGUGUUGUGA
AAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCUUAUCCUUUGUUGCCAGCGGUCCGGC
CGGGAACUCAAAGGAGACUGCCAGUGAUAAACUGGAGGAAGGUGGGGAUGACGUCAAGUC
AUCAUGGCCCUUACGACCAGGGCUACACACGUGCUACAAUGGCGCAUACAAAGAGAAGCG
ACCUCGCGAGAGCAAGCGGACCUCAUAAAGUGCGUCGUAGUCCGGAUUGGAGUCUGCAAC
UCGACUCCAUGAAGUCGGAAUCGCUAGUAAUCGUGGAUCAGAAUGCCACGGUGAAUACGU
UCCCGGGCCUUGUACACACCGCCCGUCACACCAUGGGAGUGGGUUGCAAAAGAAGUAGGU
AGCUUAACCUUCGGGAGGGCGCUUACCACUUUGUGAUUCAUGACUGGGGUGAAGUCGUAA
CAAGGUAACCGUAGGGGAACCUGCGGUUGGAUCACCUCCUUA
Sequence of entity 2 (AX), FASTA
>4V6M_2 mRNA (chains AX)
UCGCCCCUGAA
Sequence of entity 3 (AV), FASTA
>4V6M_3 FtsQ nascent chain (chains AV)
CGGCACGUAGCGCAGCCUGGUAGCGCACCGUCAUGGGGUGUCGGGGGUCGGAGGUUCAAA
UCCUCUCGUGCCGACCA
Sequence of entity 4 (AZ), FASTA
>4V6M_4 Cell division protein FtsQ (chains AZ)
GTRLAGILFLLTVLTTVLVSGWVVLGWMEDAQRLPLSKLVLTGERHYTRNDDIRQSILAL
GEPGTFMTQDVNIIQTQIEQRLQHARLDKPGARHPCWP
Sequence of entity 5 (A0, A1), FASTA
>4V6M_5 Apolipoprotein A-I (chains A0, A1)
LKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDD
FQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHL
APYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLE
SFKVSFLSALEEYTKKLNTQ
Sequence of entity 6 (AB), FASTA
>4V6M_6 30S ribosomal protein S2 (chains AB)
ATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIA
SRKGKILFVGTKRAASEAVKDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQS
QDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGI
PVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEAE
Sequence of entity 7 (AC), FASTA
>4V6M_7 30S ribosomal protein S3 (chains AC)
GQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPA
KSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSIT
SQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRAD
IDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK
Sequence of entity 8 (AD), FASTA
>4V6M_8 30S ribosomal protein S4 (chains AD)
ARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKV
RRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHK
AIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGT
FKRKPERSDLSADINEHLIVELYSK
Sequence of entity 9 (AE), FASTA
>4V6M_9 30S ribosomal protein S5 (chains AE)
AHIEKQAGELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQ
KAMEKARRNMINVALNNGTLQHPVKGVHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVH
NVLAKAYGSTNPINVVRATIDGLENMNSPEMVAAKRGKSVEEILGK
Sequence of entity 10 (AF), FASTA
>4V6M_10 30S ribosomal protein S6 (chains AF)
MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYV
LMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANET
ADDAEAGDSEEEEEE
Sequence of entity 11 (AG), FASTA
>4V6M_11 30S ribosomal protein S7 (chains AG)
PRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEA
FEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLA
NELSDAAENKGTAVKKREDVHRMAEANKAFAHYRWLSLRSFSHQAGASSKQPALGYLN
Sequence of entity 12 (AH), FASTA
>4V6M_12 30S ribosomal protein S8 (chains AH)
SMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELEL
TLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGL
GGEIICYVA

Ligands and cofactors

IDNameFormulaCopies
PGV(1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoylo…C40 H77 O10 P32
PEV(1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl…C39 H78 N O8 P101

Primary citation

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Frauenfeld, J., Gumbart, J., Sluis, E.O. et al. Nat Struct Mol Biol (2011) 18:614-621. DOI 10.1038/nsmb.2026 · PubMed

Browse structure collections

About this viewer

MolViewer shows 4V6M directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.