Apolipoprotein A-I (APOA1) is a 267-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02647.
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The mean pLDDT of this model is 73.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 2% |
| 70 to 90 | Confident: backbone generally right | 61% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility
Homodimer (By similarity). Interacts with NAXE and CLU (PubMed:11991719, PubMed:1742316). Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin (PubMed:1909888). Interacts with NDRG1 (PubMed:15922294). Interacts with SCGB3A2 (PubMed:12847263). Interacts with NAXE and YJEFN3 (PubMed:23719382)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7KJR | EM | 2.08 Å | C/D=79-267 |
| 9PVY | EM | 2.15 Å | A/B/C/D/E/F/G/H/I/J=25-267 |
| 3R2P | X-ray | 2.2 Å | A=25-208 |
| 9PVZ | EM | 2.3 Å | A/B/C/D/E/F/G/H/I/J=25-267 |
| 8VXJ | X-ray | 2.7 Å | C/D=25-267 |
| 9PW3 | EM | 2.73 Å | A/B/C/D/E/F/G/H/I/J=25-267 |
| 8EQS | EM | 3.1 Å | C/D=79-267 |
| 1AV1 | X-ray | 4.0 Å | A/B/C/D=68-267 |
| 4V6M | EM | 7.1 Å | A0/A1=68-267 |
| 9MXZ | EM | 9.8 Å | A/E=25-267 |
| 1GW3 | NMR | A=166-211 | |
| 1GW4 | NMR | A=166-211 | |
| 1ODP | NMR | A=190-209 | |
| 1ODQ | NMR | A=190-209 | |
| 1ODR | NMR | A=190-209 | |
| 2MSC | NMR | A/C=68-265 | |
| 2MSD | NMR | A/C=68-265 | |
| 2MSE | NMR | A/C=68-265 | |
| 2N5E | NMR | A/B=79-267 | |
| 3K2S | X-ray | A/B=25-267 |
Showing 20 of 31 experimental structures (best resolution first).
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