4XBR: In cellulo Crystal Structure of PAK4

In cellulo Crystal Structure of PAK4 in complex with Inka. Determined by X-ray diffraction at 2.94 Å resolution. Released 2 Dec 2015.

Method: X-ray diffraction
Resolution: 2.94 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,536
Mol. weight: 41.8 kDa
Ligands: MG, ATP
Released: 2 Dec 2015

Explore 4XBR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4XBR contains 22 α-helices and 17 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	184-185	2	1
α-helix	191-194	4
α-helix	298-311	14
α-helix	317-319	3
β-strand	321-329	9	2
β-strand	334-340	7	2
β-strand	346-353	8	2
α-helix	360-362	3
α-helix	363-372	10
β-strand	378	1	3
β-strand	381-387	7	2
β-strand	390-395	6	2
β-strand	401-402	2	3
α-helix	403-408	6
α-helix	414-433	20
β-strand	436-437	2	4
α-helix	443-445	3
β-strand	446-448	3	3
β-strand	454-456	3	3
α-helix	459-461	3
β-strand	463-464	2	4
β-strand	466	1	5
β-strand	469	1	5
β-strand	472	1	6
β-strand	476-477	2	1
α-helix	479-481	3
α-helix	484-487	4
β-strand	492	1	6
α-helix	495-510	16
α-helix	520-529	10
α-helix	531-533	3
α-helix	543-552	10
α-helix	561-562	2
α-helix	563-566	4
α-helix	570-574	5
α-helix	575-577	3
α-helix	578-580	3
α-helix	582-584	3
α-helix	586-588	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein FAM212A,Serine/threonine-protein kinase PAK 4	A	protein	366	Homo sapiens	O96013 (AlphaFold model), Q96EL1 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4XBR_1 Protein FAM212A,Serine/threonine-protein kinase PAK 4 (chains A)
MDYKDDDDKSGSEAEDWTAALLNRGRSRQPLVLGDNCFADLVHNWMELPEEFPAAPAVPG
PPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGK
LVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD
IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV
SKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMK
MIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM
RQNRTR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	2
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	1

Primary citation

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. Baskaran, Y., Ang, K.C., Anekal, P.V. et al. Nat Commun (2015) 6:8681-8681. DOI 10.1038/ncomms9681 · PubMed

Other PDB entries of the same protein (UniProt O96013 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2J0I 1.6 Å, Crystal structure of the human P21-activated kinase 4
2Q0N 1.75 Å, Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide
5VEF 1.75 Å, PAK4 kinase domain in complex with fasudil
5ZJW 1.8 Å, Crystal Structure of PAK4 in complex with inhibitor CZg353
5XVA 1.85 Å, Crystal Structure of PAK4 in complex with inhibitor CZH216
4JDI 1.85 Å, Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide S…
8AHG 1.89 Å, PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit…
6WLY 1.9 Å, PAK4 kinase domain in complex with LIMK1 Thr508 substrate peptide
7S48 1.9 Å, PAK4cat in complex with Integrin beta5 760-770 peptide
4FIH 1.97 Å, Catalytic domain of human PAK4 with QKFTGLPRQW peptide
4FII 2.0 Å, Catalytic domain of human PAK4 with RPKPLVDP peptide
4JDH 2.0 Å, Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide T…

Browse structure collections

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