4XDN: Scc4

Crystal structure of Scc4 in complex with Scc2n. Determined by X-ray diffraction at 2.08 Å resolution. Released 17 Jun 2015.

Method
X-ray diffraction
Resolution
2.08 Å
Organism
Saccharomyces cerevisiae
Chains
2
Atoms
6,189
Mol. weight
96.91 kDa
Released
17 Jun 2015

Explore 4XDN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4XDN contains 40 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 35 helices, 4 β-strands

ElementResiduesLengthSheet
β-strand7-931
α-helix10-2617
α-helix34-5724
α-helix62-7918
β-strand8012
α-helix83-10018
α-helix107-1159
α-helix116-1205
α-helix121-1255
α-helix128-14619
α-helix151-17020
α-helix174-18714
α-helix1891
α-helix193-20917
α-helix211-2144
α-helix215-2228
α-helix226-2294
α-helix231-24717
α-helix253-27220
β-strand278-28363
β-strand286-29163
α-helix293-2964
α-helix298-31215
α-helix320-34122
α-helix350-37930
α-helix396-40712
α-helix413-4219
α-helix427-44721
α-helix453-47119
α-helix475-4784
α-helix480-49415
α-helix502-5043
α-helix507-52418
α-helix539-5413
α-helix544-55714
α-helix562-57514
α-helix576-5783
α-helix583-60018
α-helix603-62018
Chain B: 5 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix-3-04
α-helix14-174
α-helix32-376
β-strand41-4333
β-strand59-6131
α-helix79-813
β-strand85-8732
α-helix112-1209
β-strand128-13032

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
MAU2 chromatid cohesion factor homologAprotein643Saccharomyces cerevisiaeP40090 (AlphaFold model)
Sister chromatid cohesion protein 2Bprotein200Saccharomyces cerevisiaeQ04002 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>4XDN_1 MAU2 chromatid cohesion factor homolog (chains A)
MKSSHHHHHHENLYFQSNAMENLGDKLSISQVYHLAQEYRDHAYSIANKIGSEEGLKQYY
GLMNMSIQMFQLLKTKCTLSVLEDSKVTFEMVELLIQETYNFDLAELYISSLKERLQTHQ
SDTDLVEEIMRCEFLLLHDLPLMRDSKFHYKIALRNCNELVQYMVNLQDELYQNWASVFQ
YVGVMLCIKLKQHRRVKTSFHGLLSQCREKSQWKWFLNLCYVNYLLNERFPIPEDALQEL
RSTELHTVGPELYAWKLALEMVIQLCKDGNITDHLNEFKNFFDTNKQSLVTNEGKGCVIK
IMPRIALKVELPMIFHYKELKNILLLLQSVSYIVNCYDEKGNFSRKFLPKVYSTTQKLIK
NIAAGGVSMNELDSRIQTYKSILEFCEFYKVWEQTLLKGAVVTTESPKLGPSPGYVRLLQ
AMKVQFEGGGAVEEYTRLAQSGGTSSEVKMISLLNCYTVQAARVSRCSGDKQGELVEQCN
KVWLQVEKLLQETDLQFNPIWECTVTILWLFSHFEPFSWNPLPCSDKQRAEYVSKLREFY
SSNKFVAGEAVADNRFKLKKALLLQILVNYLGGRMLEHDLGEIYAISAKCFDMCRQQGGM
RKVQYVIGIWHLMNCTVAMRGKDVALTNAKLEALVKQITSVKQ
Sequence of entity 2 (B), FASTA
>4XDN_2 Sister chromatid cohesion protein 2 (chains B)
MKSSHHHHHHENLYFQSNAMSYPGKDKNIPGRIIEALEDLPLSYLVPKDGLAALVNAPMR
VSLPFDKTIFTSADDGRDVNINVLGTANSTTSSIKNEAEKERLVFKRPSNFTSSANSVDY
VPTNFLEGLSPLAQSVLSTHKGLNDSINIEKKSEIVSRPEAKHKLESVTSNAGNLSFNDN
SSNKKTKTSTGVTMTQANLA

Primary citation

Structural evidence for Scc4-dependent localization of cohesin loading. Hinshaw, S.M., Makrantoni, V., Kerr, A. et al. Elife (2015) 4:e06057-e06057. DOI 10.7554/eLife.06057 · PubMed

Other PDB entries of the same protein (UniProt P40090 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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