4YRU: Neuronal calcium sensor 1

Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus. Determined by X-ray diffraction at 2.8 Å resolution. Released 1 Apr 2015.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: Rattus norvegicus
Chains: 4
Atoms: 5,214
Mol. weight: 82.65 kDa
Ligands: CA
Released: 1 Apr 2015

Explore 4YRU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4YRU contains 36 α-helices and 16 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	26-37	12
β-strand	43-44	2	1
α-helix	45-55	11
α-helix	62-72	11
β-strand	79-80	2	1
α-helix	82-93	12
α-helix	97-108	12
β-strand	116-117	2	2
α-helix	118-132	15
α-helix	145-156	12
β-strand	163-164	2	2
α-helix	166-173	8

Chain B: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	15-18	4
α-helix	26-37	12
β-strand	43-44	2	3
α-helix	45-55	11
α-helix	62-72	11
β-strand	79-80	2	3
α-helix	82-93	12
α-helix	97-108	12
β-strand	116-117	2	4
α-helix	118-132	15
α-helix	145-156	12
β-strand	163-164	2	4
α-helix	166-174	9

Chain C: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	15-18	4
α-helix	26-34	9
β-strand	44	1	5
α-helix	45-55	11
α-helix	62-72	11
β-strand	79	1	5
α-helix	82-94	13
α-helix	97-108	12
β-strand	116-117	2	6
α-helix	118-132	15
α-helix	145-156	12
β-strand	163-164	2	6
α-helix	166-173	8

Chain D: 10 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	12-18	7
α-helix	26-35	10
β-strand	44	1	7
α-helix	45-55	11
α-helix	62-72	11
β-strand	79	1	7
α-helix	82-93	12
α-helix	97-108	12
β-strand	116-117	2	8
α-helix	118-128	11
α-helix	129-133	5
α-helix	145-156	12
β-strand	163-164	2	8
α-helix	166-172	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neuronal calcium sensor 1	A, B, C, D	protein	177	Rattus norvegicus	P62168 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>4YRU_1 Neuronal calcium sensor 1 (chains A, B, C, D)
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD
PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
MLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADP

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	12

Primary citation

Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions. Pandalaneni, S., Karuppiah, V., Saleem, M. et al. J Biol Chem (2015) 290:18744-18756. DOI 10.1074/jbc.M114.627059 · PubMed

Other PDB entries of the same protein (UniProt P62168 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5AEQ 1.95 Å, Neuronal calcium sensor (NCS-1)from Rattus norvegicus
5AER 2.19 Å, Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine…
5AFP 2.3 Å, Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase…
4OV2 2.6 Å, Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus…

Browse structure collections

About this viewer

MolViewer shows 4YRU directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.