Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail. Determined by X-ray diffraction at 1.79 Å resolution. Released 1 Apr 2015.
Explore 4YYX in 3D Show helices and sheets RCSB PDB PDBe
4YYX contains 4 α-helices and 16 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 20-27 | 8 | 1 |
| β-strand | 29 | 1 | 2 |
| β-strand | 33 | 1 | 2 |
| β-strand | 36-39 | 4 | 1 |
| β-strand | 55-59 | 5 | 1 |
| α-helix | 73 | 1 | |
| β-strand | 74-78 | 5 | 1 |
| β-strand | 81-82 | 2 | 1 |
| α-helix | 88-96 | 9 | |
| β-strand | 101-108 | 8 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tight junction protein ZO-1 fused with Claudin-2 C-terminal | A, B | protein | 107 | Homo sapiens | P57739 (AlphaFold model), Q07157 (AlphaFold model) |
>4YYX_1 Tight junction protein ZO-1 fused with Claudin-2 C-terminal (chains A, B) GSHMIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQEND RVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKGGGYSLTGYV
Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins. Nomme, J., Antanasijevic, A., Caffrey, M. et al. J Biol Chem (2015) 290:16595-16606. DOI 10.1074/jbc.M115.646695 · PubMed
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