Tight junction protein 1 (TJP1) is a 1748-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07157.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 54.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly…
Homodimer (PubMed:16737969, PubMed:17928286). Forms heterodimers TJP3 (By similarity). Forms a heterodimer (via PDZ2 domain) with TJP2/ZO2 (via PDZ2 domain) (PubMed:17897942, PubMed:9792688). Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1 (PubMed:11734628, PubMed:12023291, PubMed:12154091, PubMed:15183511, PubMed:18823282, PubMed:20200156, PubMed:7798316).…
Cell membrane, Cell junction, tight junction, Cell junction, Cell junction, gap junction, Cell projection, podosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4Q2Q | X-ray | 1.45 Å | A=419-504 |
| 2H2B | X-ray | 1.6 Å | A=18-110 |
| 2RCZ | X-ray | 1.7 Å | A/B=186-264 |
| 9HM2 | X-ray | 1.72 Å | A/B=186-263 |
| 4YYX | X-ray | 1.79 Å | A/B=18-110 |
| 4OEO | X-ray | 1.9 Å | A/B/C=18-110 |
| 3TSV | X-ray | 1.99 Å | A=417-516 |
| 2H2C | X-ray | 2.0 Å | A=18-110 |
| 4OEP | X-ray | 2.35 Å | A/B=18-110 |
| 3CYY | X-ray | 2.4 Å | A/B=182-273 |
| 3TSZ | X-ray | 2.5 Å | A=417-803 |
| 3LH5 | X-ray | 2.6 Å | A=516-803 |
| 3SHU | X-ray | 2.75 Å | A/B=421-512 |
| 3TSW | X-ray | 2.85 Å | A/B/C/D=417-803 |
| 2H3M | X-ray | 2.9 Å | A=18-110 |
| 3SHW | X-ray | 2.9 Å | A=421-888 |
| 2JWE | NMR | A/B=185-264 | |
| 2KXR | NMR | A=1631-1748 | |
| 2KXS | NMR | A=1631-1748 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.