Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10). Determined by X-ray diffraction at 3.3 Å resolution. Released 18 May 2016.
Explore 4ZRY in 3D Show helices and sheets RCSB PDB PDBe
4ZRY contains 3 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 348-455 | 108 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 387-476 | 90 | |
| α-helix | 478-488 | 11 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Keratin, type I cytoskeletal 10 | A | protein | 124 | Homo sapiens | P13645 (AlphaFold model) |
| Keratin, type II cytoskeletal 1 | B | protein | 120 | Homo sapiens | P04264 (AlphaFold model) |
>4ZRY_1 Keratin, type I cytoskeletal 10 (chains A) GSHMEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEAS LAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIKIRLENEIQTYRSL LEGE
>4ZRY_2 Keratin, type II cytoskeletal 1 (chains B) ESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDA EQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGE
The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease. Bunick, C.G., Milstone, L.M. J Invest Dermatol (2017) 137:142-150. DOI 10.1016/j.jid.2016.08.018 · PubMed
Other PDB entries of the same protein (UniProt P13645 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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