5A9Q: Human nuclear pore complex
Human nuclear pore complex. Determined by electron microscopy at 23.0 Å resolution. Released 30 Sept 2015.
- Method
- Electron microscopy
- Resolution
- 23.0 Å
- Organism
- HOMO SAPIENS
- Chains
- 38
- Atoms
- 95,884
- Mol. weight
- 3243.76 kDa
- Released
- 30 Sept 2015
Explore 5A9Q in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5A9Q contains 814 α-helices and 752 β-strands across 38 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains 0, 9, I and R: 3 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-8 | 4 | 1 |
| β-strand | 13-18 | 6 | 2 |
| α-helix | 19-22 | 4 | |
| α-helix | 28-29 | 2 | |
| β-strand | 31-36 | 6 | 2 |
| β-strand | 42-48 | 7 | 2 |
| β-strand | 66-73 | 8 | 2 |
| β-strand | 77-82 | 6 | 3 |
| β-strand | 87-92 | 6 | 3 |
| β-strand | 97-102 | 6 | 3 |
| β-strand | 109-115 | 7 | 3 |
| β-strand | 134-140 | 7 | 4 |
| β-strand | 143-148 | 6 | 4 |
| β-strand | 152-157 | 6 | 4 |
| β-strand | 165-168 | 4 | 4 |
| β-strand | 175-180 | 6 | 5 |
| β-strand | 185-190 | 6 | 5 |
| β-strand | 194-199 | 6 | 5 |
| β-strand | 209-212 | 4 | 5 |
| β-strand | 220-225 | 6 | 6 |
| β-strand | 232-237 | 6 | 6 |
| β-strand | 242-246 | 5 | 6 |
| β-strand | 255-257 | 3 | 6 |
| β-strand | 264-269 | 6 | 7 |
| β-strand | 276-281 | 6 | 7 |
| β-strand | 286-290 | 5 | 7 |
| β-strand | 341-344 | 4 | 7 |
| α-helix | 347 | 1 | |
| β-strand | 353-359 | 7 | 1 |
| β-strand | 362-367 | 6 | 1 |
| β-strand | 371-375 | 5 | 1 |
Chains 1, a, J and S: 48 helices, 37 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-51 | 7 | 9 |
| β-strand | 60-63 | 4 | 10 |
| α-helix | 64-66 | 3 | |
| α-helix | 76-79 | 4 | |
| β-strand | 84-88 | 5 | 10 |
| α-helix | 100-101 | 2 | |
| β-strand | 102-108 | 7 | 10 |
| β-strand | 115-120 | 6 | 10 |
| β-strand | 128-131 | 4 | 10 |
| α-helix | 137-138 | 2 | |
| β-strand | 143-144 | 2 | 11 |
| β-strand | 151-156 | 6 | 11 |
| β-strand | 161-166 | 6 | 11 |
| α-helix | 170-173 | 4 | |
| α-helix | 193-195 | 3 | |
| β-strand | 199-202 | 4 | 11 |
| β-strand | 215-219 | 5 | 12 |
| β-strand | 226-230 | 5 | 12 |
| β-strand | 238-242 | 5 | 12 |
| β-strand | 253-257 | 5 | 12 |
| β-strand | 265 | 1 | 13 |
| β-strand | 285-291 | 7 | 13 |
| β-strand | 298-303 | 6 | 13 |
| β-strand | 307-312 | 6 | 13 |
| β-strand | 317-323 | 7 | 13 |
| β-strand | 346-348 | 3 | 14 |
| β-strand | 355-360 | 6 | 14 |
| β-strand | 367-375 | 9 | 14 |
| β-strand | 381-387 | 7 | 14 |
| β-strand | 391 | 1 | 14 |
| β-strand | 395-402 | 8 | 15 |
| β-strand | 405-412 | 8 | 15 |
| β-strand | 416-425 | 10 | 15 |
| β-strand | 429-434 | 6 | 15 |
| β-strand | 435 | 1 | 9 |
| α-helix | 444-446 | 3 | |
| α-helix | 453-462 | 10 | |
| α-helix | 469-478 | 10 | |
| α-helix | 484-488 | 5 | |
| α-helix | 491-505 | 15 | |
| β-strand | 508 | 1 | 16 |
| β-strand | 510 | 1 | 17 |
| β-strand | 515 | 1 | 17 |
| α-helix | 517-540 | 24 | |
| α-helix | 541-543 | 3 | |
| β-strand | 545-551 | 7 | 9 |
| β-strand | 556-561 | 6 | 9 |
| β-strand | 564-570 | 7 | 9 |
| α-helix | 571-572 | 2 | |
| α-helix | 573-578 | 6 | |
| α-helix | 582-587 | 6 | |
| α-helix | 602-616 | 15 | |
| α-helix | 619-632 | 14 | |
| α-helix | 638-642 | 5 | |
| α-helix | 643-648 | 6 | |
| α-helix | 649 | 1 | |
| α-helix | 655-664 | 10 | |
| α-helix | 668-679 | 12 | |
| β-strand | 703 | 1 | 18 |
| α-helix | 707-709 | 3 | |
| α-helix | 710-742 | 33 | |
| α-helix | 747-752 | 6 | |
| α-helix | 763-782 | 20 | |
| α-helix | 814-816 | 3 | |
| α-helix | 822-829 | 8 | |
| β-strand | 832 | 1 | 18 |
| α-helix | 853-866 | 14 | |
| α-helix | 872-873 | 2 | |
| α-helix | 874-884 | 11 | |
| α-helix | 888-893 | 6 | |
| α-helix | 907-919 | 13 | |
| α-helix | 923-932 | 10 | |
| α-helix | 944-946 | 3 | |
| α-helix | 947-955 | 9 | |
| α-helix | 960-972 | 13 | |
| α-helix | 976-989 | 14 | |
| α-helix | 994-1011 | 18 | |
| α-helix | 1016-1027 | 12 | |
| α-helix | 1031-1044 | 14 | |
| α-helix | 1047-1056 | 10 | |
| α-helix | 1059-1073 | 15 | |
| α-helix | 1081-1092 | 12 | |
| α-helix | 1096-1112 | 17 | |
| α-helix | 1117-1134 | 18 | |
| α-helix | 1177-1199 | 23 | |
Chains 2, b, K and T: 0 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-14 | 4 | 26 |
| β-strand | 21-23 | 3 | 27 |
| β-strand | 35-39 | 5 | 27 |
| β-strand | 43-50 | 8 | 27 |
| β-strand | 62-70 | 9 | 27 |
| β-strand | 75-80 | 6 | 28 |
| β-strand | 85-86 | 2 | 29 |
| β-strand | 91-92 | 2 | 29 |
| β-strand | 93-99 | 7 | 28 |
| β-strand | 104-109 | 6 | 28 |
| β-strand | 113-117 | 5 | 28 |
| β-strand | 127-135 | 9 | 30 |
| β-strand | 137-144 | 8 | 30 |
| β-strand | 148-154 | 7 | 30 |
| β-strand | 158-163 | 6 | 30 |
| β-strand | 168-174 | 7 | 31 |
| β-strand | 177-185 | 9 | 31 |
| β-strand | 190-194 | 5 | 31 |
| β-strand | 200-204 | 5 | 31 |
| β-strand | 213-217 | 5 | 32 |
| β-strand | 222-226 | 5 | 32 |
| β-strand | 231-235 | 5 | 32 |
| β-strand | 244 | 1 | 16 |
| β-strand | 250-253 | 4 | 32 |
| β-strand | 258-259 | 2 | 33 |
| β-strand | 266-270 | 5 | 33 |
| β-strand | 279-284 | 6 | 33 |
| β-strand | 293-294 | 2 | 33 |
| β-strand | 299-304 | 6 | 26 |
| β-strand | 310-315 | 6 | 26 |
| β-strand | 318-323 | 6 | 26 |
Chains 3, C, L and U: 35 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 522-525 | 4 | |
| α-helix | 544-549 | 6 | |
| α-helix | 562-569 | 8 | |
| α-helix | 599-607 | 9 | |
| α-helix | 613-616 | 4 | |
| α-helix | 639-650 | 12 | |
| α-helix | 662-671 | 10 | |
| α-helix | 687-690 | 4 | |
| α-helix | 694-696 | 3 | |
| α-helix | 724-734 | 11 | |
| α-helix | 737-740 | 4 | |
| α-helix | 779-787 | 9 | |
| α-helix | 797-802 | 6 | |
| α-helix | 806-822 | 17 | |
| α-helix | 830-832 | 3 | |
| α-helix | 835-841 | 7 | |
| α-helix | 850-853 | 4 | |
| α-helix | 859-865 | 7 | |
| α-helix | 870-879 | 10 | |
| α-helix | 885-891 | 7 | |
| α-helix | 897-900 | 4 | |
| α-helix | 902-905 | 4 | |
| α-helix | 922-924 | 3 | |
| α-helix | 926-930 | 5 | |
| α-helix | 936-942 | 7 | |
| α-helix | 946-959 | 14 | |
| α-helix | 964-980 | 17 | |
| α-helix | 985-1006 | 22 | |
| α-helix | 1012-1015 | 4 | |
| α-helix | 1028-1034 | 7 | |
| α-helix | 1045-1049 | 5 | |
| α-helix | 1066-1079 | 14 | |
| α-helix | 1096-1103 | 8 | |
| α-helix | 1125-1128 | 4 | |
| α-helix | 1144-1147 | 4 | |
Chains 4 and M: 40 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 151-153 | 3 | |
| α-helix | 154-167 | 14 | |
| α-helix | 171-190 | 20 | |
| α-helix | 203-231 | 29 | |
| α-helix | 249-259 | 11 | |
| α-helix | 261-275 | 15 | |
| α-helix | 298-302 | 5 | |
| α-helix | 326-330 | 5 | |
| α-helix | 337-356 | 20 | |
| α-helix | 359-369 | 11 | |
| α-helix | 372-379 | 8 | |
| β-strand | 383 | 1 | 52 |
| α-helix | 384 | 1 | |
| β-strand | 385 | 1 | 53 |
| β-strand | 399 | 1 | 53 |
| β-strand | 401 | 1 | 52 |
| α-helix | 404-416 | 13 | |
| α-helix | 422-432 | 11 | |
| α-helix | 438-441 | 4 | |
| α-helix | 445-467 | 23 | |
| α-helix | 473-475 | 3 | |
| α-helix | 489-499 | 11 | |
| α-helix | 506-509 | 4 | |
| α-helix | 511-521 | 11 | |
| α-helix | 525-534 | 10 | |
| α-helix | 544-560 | 17 | |
| α-helix | 566-583 | 18 | |
| α-helix | 587-589 | 3 | |
| α-helix | 590-593 | 4 | |
| α-helix | 597-600 | 4 | |
| α-helix | 668-680 | 13 | |
| α-helix | 682-684 | 3 | |
| α-helix | 685-700 | 16 | |
| α-helix | 705-714 | 10 | |
| α-helix | 719-723 | 5 | |
| α-helix | 738-767 | 30 | |
| α-helix | 770-776 | 7 | |
| α-helix | 782-821 | 40 | |
| α-helix | 837-838 | 2 | |
| α-helix | 840-867 | 28 | |
| α-helix | 871-875 | 5 | |
| α-helix | 877-882 | 6 | |
| α-helix | 888-891 | 4 | |
| α-helix | 894-913 | 20 | |
Chains 5, E and N: 23 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 278-289 | 12 | |
| β-strand | 296-298 | 3 | 54 |
| β-strand | 304-306 | 3 | 54 |
| β-strand | 317-319 | 3 | 54 |
| α-helix | 321-323 | 3 | |
| α-helix | 331-334 | 4 | |
| α-helix | 336-345 | 10 | |
| β-strand | 348 | 1 | 55 |
| β-strand | 357 | 1 | 55 |
| α-helix | 366-371 | 6 | |
| α-helix | 388-400 | 13 | |
| α-helix | 412-443 | 32 | |
| α-helix | 451-460 | 10 | |
| α-helix | 463-473 | 11 | |
| α-helix | 476-483 | 8 | |
| α-helix | 491-502 | 12 | |
| α-helix | 513-523 | 11 | |
| α-helix | 538-541 | 4 | |
| α-helix | 544-554 | 11 | |
| α-helix | 562-572 | 11 | |
| α-helix | 611-620 | 10 | |
| α-helix | 626-634 | 9 | |
| α-helix | 642-655 | 14 | |
| α-helix | 662-679 | 18 | |
| α-helix | 682-690 | 9 | |
| α-helix | 695-714 | 20 | |
| α-helix | 722-728 | 7 | |
| α-helix | 733-747 | 15 | |
Chains 6 and O: 5 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16-21 | 6 | 58 |
| α-helix | 22 | 1 | |
| α-helix | 23-25 | 3 | |
| β-strand | 27-32 | 6 | 58 |
| β-strand | 36-43 | 8 | 58 |
| β-strand | 46-54 | 9 | 58 |
| β-strand | 60-65 | 6 | 59 |
| α-helix | 66-67 | 2 | |
| α-helix | 68-70 | 3 | |
| β-strand | 74-78 | 5 | 59 |
| β-strand | 83-86 | 4 | 59 |
| β-strand | 95-99 | 5 | 59 |
| β-strand | 108-111 | 4 | 60 |
| β-strand | 119-123 | 5 | 60 |
| β-strand | 129-134 | 6 | 60 |
| β-strand | 140-142 | 3 | 60 |
| β-strand | 145 | 1 | 60 |
| β-strand | 153 | 1 | 61 |
| β-strand | 157-158 | 2 | 62 |
| α-helix | 159-160 | 2 | |
| β-strand | 181 | 1 | 63 |
| β-strand | 182-183 | 2 | 62 |
| β-strand | 186 | 1 | 61 |
| β-strand | 190 | 1 | 64 |
| β-strand | 193-196 | 4 | 63 |
| β-strand | 202-206 | 5 | 63 |
| β-strand | 209 | 1 | 64 |
| β-strand | 215-219 | 5 | 65 |
| β-strand | 230-235 | 6 | 65 |
| β-strand | 239-244 | 6 | 65 |
| β-strand | 254 | 1 | 65 |
| β-strand | 257-260 | 4 | 65 |
| β-strand | 265-270 | 6 | 66 |
| β-strand | 277-281 | 5 | 66 |
| β-strand | 286-291 | 6 | 66 |
| β-strand | 297-302 | 6 | 66 |
Chains 7, G, P and Y: 1 helix, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2 | 1 | 69 |
| β-strand | 7-8 | 2 | 70 |
| β-strand | 15-20 | 6 | 71 |
| β-strand | 26-31 | 6 | 71 |
| β-strand | 35-41 | 7 | 71 |
| β-strand | 45 | 1 | 69 |
| β-strand | 47-54 | 8 | 71 |
| β-strand | 60-65 | 6 | 72 |
| β-strand | 73-78 | 6 | 72 |
| β-strand | 83-88 | 6 | 72 |
| β-strand | 103-109 | 7 | 72 |
| β-strand | 116-121 | 6 | 73 |
| α-helix | 124-126 | 3 | |
| β-strand | 129-134 | 6 | 73 |
| β-strand | 138-143 | 6 | 73 |
| β-strand | 154-160 | 7 | 73 |
| β-strand | 167-170 | 4 | 74 |
| β-strand | 181-185 | 5 | 74 |
| β-strand | 198-202 | 5 | 74 |
| β-strand | 209-213 | 5 | 74 |
| β-strand | 224-227 | 4 | 75 |
| β-strand | 236-241 | 6 | 75 |
| β-strand | 245-251 | 7 | 75 |
| β-strand | 257 | 1 | 76 |
| β-strand | 260 | 1 | 76 |
| β-strand | 267-274 | 8 | 75 |
| β-strand | 283-286 | 4 | 77 |
| β-strand | 293-296 | 4 | 77 |
| β-strand | 302-307 | 6 | 77 |
| β-strand | 313-320 | 8 | 77 |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Nucleoporin NUP43 | 0, 9, I, R | protein | 380 | HOMO SAPIENS | Q8NFH3 (AlphaFold model) |
| Nuclear pore complex protein NUP160 | 1, J, S, a | protein | 1436 | HOMO SAPIENS | Q12769 (AlphaFold model) |
| Nucleoporin NUP37 | 2, K, T, b | protein | 326 | HOMO SAPIENS | Q8NFH4 (AlphaFold model) |
| Nuclear pore complex protein NUP133 | 3, C, L, U | protein | 1156 | HOMO SAPIENS | Q8WUM0 (AlphaFold model) |
| Nuclear pore complex protein NUP107 | 4, D, M, V | protein | 925 | HOMO SAPIENS | P57740 |
| Nuclear pore complex protein NUP96 | 5, E, N, W | protein | 937 | HOMO SAPIENS | P52948 |
| Protein SEC13 homolog | 6, F, O, X | protein | 322 | HOMO SAPIENS | P55735 |
| Nucleoporin SEH1 | 7, G, P, Y | protein | 360 | HOMO SAPIENS | Q96EE3 |
| Nuclear pore complex protein NUP85 | 8, H, Q, Z | protein | 656 | HOMO SAPIENS | Q9BW27 |
| Nuclear pore complex protein NUP155 | A, B | protein | 1391 | HOMO SAPIENS | O75694 |
Sequence of entity 1 (0, 9, I, R), FASTA
>5A9Q_1 NUCLEOPORIN NUP43 (chains 0, 9, I, R)
MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGG
FEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHY
HTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTF
LRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDG
MLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSS
LFHQGGRSSTFLSHSISNQANVHQSVISSWLSTDPAKDRIEITSLLPSRSLSVNTLDVLG
PCLVCGTDAEAIYVTRHLFS
Sequence of entity 2 (1, J, S, a), FASTA
>5A9Q_2 NUCLEAR PORE COMPLEX PROTEIN NUP160 (chains 1, J, S, a)
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFR
EFTVCSIGTANAVAGAVKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLD
INLLNNAIRLKFQNCSVLPGGVYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVD
SQMQSIFTDIGKVDFTDPCNYQLIPAVPGISPNSTASTAWLSSDGEALFALPCASGGIFV
LKLPPYDIPGMVSVVELKQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIF
ALCQDHKLRMWSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYM
HAPKRGQFCIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVK
YINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFC
RGTERNLDLSWSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQE
ALSHPLALHLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIA
RDVICLIKCLRLIEESVTVDMSVIMEMSCYNLQSPEKAAEQILEDMITIDVENVMEDICS
KLQEIRNPIHAIGLLIREMDYETEVEMEKGFNPAQPLNIRMNLTQLYGSNTAGYIVCRGV
HKIASTRFLICRDLLILQQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGS
ECLATDVPLDTLESNLQHLSVLELTDSGALMANRFVSSPQTIVELFFQEVARKHIISHLF
SQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHP
WCQVNVGSCRFMLGRCYLVTGEGQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPRL
QYYDKVLRLLDVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEA
LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNY
YELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRPEYA
WIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLAQHD
PSAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAA
QAEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVP
LPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAP
MVWLPYSSIDQLLQALGENSANSHNIALSQKILDKLEDYQQKVDKATRDLLYRRTL
Sequence of entity 3 (2, K, T, b), FASTA
>5A9Q_3 NUCLEOPORIN NUP37 (chains 2, K, T, b)
MKQDASRNAAYTVDCEDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEG
IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVL
EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPEETFK
LMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRS
SYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMGSVAVGS
GLSWHRTLPLCVIGGDHKLLFWVTEV
Sequence of entity 4 (3, C, L, U), FASTA
>5A9Q_4 NUCLEAR PORE COMPLEX PROTEIN NUP133 (chains 3, C, L, U)
MFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSS
RGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEVDDQLTINIDEGGWACLVCK
EKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATR
EGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKI
HQHILPQGQGMLSGIGRKVSSLFGILSPSSDLTLSSVLWDRERSSFYSLTSSNISKWELD
DSSEKHAYSWDINRALKENITDAIWGSESNYEAIKEGVNIRYLDLKQNCDGLVILAAAWH
SADNPCLIYYSLITIEDNGCQMSDAVTVEVTQYNPPFQSEDLILCQLTVPNFSNQTAYLY
NESAVYVCSTGTGKFSLPQEKIVFNAQGDSVLGAGACGGVPIIFSRNSGLVSITSRENVS
ILAEDLEGSLASSVAGPNSESMIFETTTKNETIAQEDKIKLLKAAFLQYCRKDLGHAQMV
VDELFSSHSDLDSDSELDRAVTQISVDLMDDYPASDPRWAESVPEEAPGFSNTSLIILHQ
LEDKMKAHSFLMDFIHQVGLFGRLGSFPVRGTPMATRLLLCEHAEKLSAAIVLKNHHSRL
SDLVNTAILIALNKREYEIPSNLTPADVFFREVSQVDTICECLLEHEEQVLRDAPMDSIE
WAEVVINVNNILKDMLQAASHYRQNRNSLYRREESLEKEPEYVPWTATSGPGGIRTVIIR
QHEIVLKVAYPQADSNLRNIVTEQLVALIDCFLDGYVSQLKSVDKSSNRERYDNLEMEYL
QKRSDLLSPLLSLGQYLWAASLAEKYCDFDILVQMCEQTDNQSRLQRYMTQFADQNFSDF
LFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHATLLGLANME
TRYFAKKKTLLGLSKLAALASDFSEDMLQEKIEEMAEQERFLLHQETLPEQLLAEKQLNL
SAMPVLTAPQLIGLYICEENRRANEYDFKKALDLLEYIDEEEDININDLKLEILCKALQR
DNWSSSDGKDDPIEVSKDSIFVKILQKLLKDGIQLSEYLPEVKDLLQADQLGSLKSNPYF
EFVLKANYEYYVQGQI
Sequence of entity 5 (4, D, M, V), FASTA
>5A9Q_5 NUCLEAR PORE COMPLEX PROTEIN NUP107 (chains 4, D, M, V)
MDRSGFGEISSPVIREAEVTRTARKQSAQKRVLLQASQDENFGNTTPRNQVIPRTPSSFR
QPFTPTSRSLLRQPDISCILGTGGKSPRLTQSSGFFGNLSMVTNLDDSNWAAAFSSQRSG
LFTNTEPHSITEDVTISAVMLREDDPGEAASMSMFSDFLQSFLKHSSSTVFDLVEEYENI
CGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVTWRLLASLYRDRIQSALEEESVF
AVTAVNASEKTVVEALFQRDSLVRQSQLVVDWLESIAKDEIGEFSDNIEFYAKSVYWENT
LHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMPLDDLDREDEVRLLKYLFTLIRAGMTE
EAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELF
NRYERAIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPR
EYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLILGDIDGLMDEFSKWLSKSRN
NLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDL
AVAQYALFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPAL
DTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLASKKHEAAKEVFVKIPQDSI
AEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQP
TFTEKVAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDH
ERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKL
LQKLRESSLMLLDQGLDPLGYEIQL
Sequence of entity 6 (5, E, N, W), FASTA
>5A9Q_6 NUCLEAR PORE COMPLEX PROTEIN NUP96 (chains 5, E, N, W)
SKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQL
GRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLT
DEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLS
PSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPR
EKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFL
PNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPN
LGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQIL
ERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLAL
LLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCS
QLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAE
EQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHL
SAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWA
KETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAII
NENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLH
IKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPL
RLLAPHIGRLPMPEDYAMDELRSLTQSYLRELAVGSL
Sequence of entity 7 (6, F, O, X), FASTA
>5A9Q_7 PROTEIN SEC13 HOMOLOG (chains 6, F, O, X)
MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV
WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL
ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK
RFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV
FIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI
SDVNKGQGSVSASVTEGQQNEQ
Sequence of entity 8 (7, G, P, Y), FASTA
>5A9Q_8 NUCLEOPORIN SEH1 (chains 7, G, P, Y)
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV
WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK
FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP
MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI
ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG
CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRKHS
Sequence of entity 9 (8, H, Q, Z), FASTA
>5A9Q_9 NUCLEAR PORE COMPLEX PROTEIN NUP85 (chains 8, H, Q, Z)
MEELDGEPTVTLIPGVNSKKNQMYFDWGPGEMLVCETSFNKKEKSEMVPSCPFIYIIRKD
VDVYSQILRKLFNESHGIFLGLQRIDEELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVA
IAAKDPANGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSL
SADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTM
PILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKEL
LSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQV
IKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLG
VDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRN
NRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGK
YREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYEL
MRCLEDLTSRRPVHGESDTEQLQDDDIETTKVEMLRLSLARNLARAIIREGSLEGS
Sequence of entity 10 (A, B), FASTA
>5A9Q_10 NUCLEAR PORE COMPLEX PROTEIN NUP155 (chains A, B)
MPSSLLGAAMPASTSAAALQEALENAGRLIDRQLQEDRMYPDLSELLMVSAPNNPTVSGM
SDMDYPLQGPGLLSVPNLPEISSIRRVPLPPELVEQFGHMQCNCMMGVFPPISRAWLTID
SDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRHLLVLATPVDIVILGLSY
ANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFLAGKDGCLYEVAY
QAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYTRSEKGVI
QVYDLGQDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLLA
VTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASSTVEKPSKVHRALYSKGILLM
AASENEDNDILWCVNHDTFPFQKPMMETQMTAGVDGHSWALSAIDELKVDKIITPLNKDH
IPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLRHLLVSNVGGDGEEIERFFK
LHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGEAQMRFPTTLPPPSNVGPILGS
PVYSSSPVPSGSPYPNPSFLGTPSHGIQPPAMSTPVCALGNPATQATNMSCVTGPEIVYS
GKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAIESSVPCQLLESVLQELKGLQEF
LDRNSQFAGGPLGNPNTTAKVQQRLIGFMRPENGNPQQMQQELQRKFHEAQLSEKISLQA
IQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKITTFKDLVIRDKELTGALIAS
LINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANELLQRSRQVQNKTEKERMLRES
LKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEPEEDIV
GLQAFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHF
EQMLKLSQRSKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYMDL
LWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEF
LHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAE
CKLAIIHCAGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPR
FFPLDFIVQFLEQQVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKP
LHLLDCIHVLLIRYVENPSQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQAITGNF
KSLQAKLERLH
Primary citation
In Situ Structural Analysis of the Human Nuclear Pore Complex. Von Appen, A., Kosinski, J., Sparks, L. et al. Nature (2015) 526:140. DOI 10.1038/NATURE15381 · PubMed
Other PDB entries of the same protein (UniProt Q8NFH3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4I79 1.75 Å, Crystal structure of human NUP43
- 7R5K 12.0 Å, Human nuclear pore complex (constricted)
- 7PEQ 35.0 Å, Model of the outer rings of the human nuclear pore complex
- 7R5J 50.0 Å, Human nuclear pore complex (dilated)
- 9A25 Molecular assembly pathway of the human Nuclear Pore Complex after cell division
- 9A8T Integrative spatiotemporal modeling of biomolecular processes: application to the…
Browse structure collections
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