Neuronal calcium sensor (NCS-1)from Rattus norvegicus. Determined by X-ray diffraction at 1.95 Å resolution. Released 18 Feb 2015.
Explore 5AEQ in 3D Show helices and sheets RCSB PDB PDBe
5AEQ contains 22 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 10-18 | 9 | |
| α-helix | 24-37 | 14 | |
| β-strand | 42-43 | 2 | 1 |
| α-helix | 45-49 | 5 | |
| α-helix | 62-72 | 11 | |
| β-strand | 80-81 | 2 | 1 |
| α-helix | 82-94 | 13 | |
| α-helix | 97-108 | 12 | |
| β-strand | 115-117 | 3 | 2 |
| α-helix | 118-130 | 13 | |
| α-helix | 140-142 | 3 | |
| α-helix | 145-156 | 12 | |
| β-strand | 163-165 | 3 | 2 |
| α-helix | 166-175 | 10 | |
| α-helix | 177-183 | 7 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 11-18 | 8 | |
| α-helix | 24-37 | 14 | |
| β-strand | 43 | 1 | 3 |
| α-helix | 45-55 | 11 | |
| α-helix | 62-72 | 11 | |
| β-strand | 80 | 1 | 3 |
| α-helix | 82-94 | 13 | |
| α-helix | 97-108 | 12 | |
| β-strand | 116-117 | 2 | 4 |
| α-helix | 118-132 | 15 | |
| α-helix | 140-142 | 3 | |
| α-helix | 145-156 | 12 | |
| β-strand | 163-164 | 2 | 4 |
| α-helix | 166-175 | 10 | |
| α-helix | 177-183 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Neuronal calcium sensor 1 | A, B | protein | 190 | RATTUS NORVEGICUS | P62168 (AlphaFold model) |
>5AEQ_1 NEURONAL CALCIUM SENSOR 1 (chains A, B) MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE MLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIV QALSLYDGLV
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 6 |
Water and common crystallization additives (NA) are not listed.
Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions. Pandalaneni, S., Karuppiah, V., Saleem, M. et al. J Biol Chem (2015) 290:18744. DOI 10.1074/JBC.M114.627059 · PubMed
Other PDB entries of the same protein (UniProt P62168 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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