5AJJ: Variola virus virulence factor F1L

Crystal structure of variola virus virulence factor F1L in complex with human Bid BH3 domain. Determined by X-ray diffraction at 1.75 Å resolution. Released 25 Mar 2015.

Method: X-ray diffraction
Resolution: 1.75 Å
Organisms: VARIOLA VIRUS, HOMO SAPIENS
Chains: 2
Atoms: 1,477
Mol. weight: 23.51 kDa
Released: 25 Mar 2015

Explore 5AJJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5AJJ contains 10 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	66-69	4
α-helix	73-96	24
α-helix	99-118	20
α-helix	120-132	13
α-helix	137-150	14
α-helix	155-169	15
α-helix	174-188	15
α-helix	191-200	10

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	82-100	19
α-helix	102	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Homolog of vaccinia virus cds F1L putative	A	protein	168	VARIOLA VIRUS	Q85365
BH3-interacting domain death agonist	B	protein	34	HOMO SAPIENS	P55957 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5AJJ_1 HOMOLOG OF VACCINIA VIRUS CDS F1L PUTATIVE (chains A)
GPLGSKASNNDDHNYVYPLPENMVYRFNKSTNILDYLSTERDHVMMAVQYYMSKQRLDDL
YRQLPTKTRSYIDIINMYCDKVNNDYNRDMNIMYDMASTESFTVYDINNEVNTMLLDNKG
LGVRLATISFITELGKRCMNPVETIKMFTLLSHTICDDCFIDYITDIS

Sequence of entity 2 (B), FASTA

>5AJJ_2 BH3-INTERACTING DOMAIN DEATH AGONIST (chains B)
QEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQ

Primary citation

Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim. Marshall, B., Puthalakath, H., Caria, S. et al. Cell Death Dis (2015) 6:E1680. DOI 10.1038/CDDIS.2015.52 · PubMed

Other PDB entries of the same protein (UniProt Q85365), best resolution first:

5AJK 2.55 Å, Crystal structure of variola virus virulence factor F1L in complex with human Bak BH3…

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