5AN4: N-glycosylase/dna lyase

Crystal structure of the human 8-oxoguanine glycosylase (OGG1) processed with the CrystalDirect automated mounting and cryo-cooling technology. Determined by X-ray diffraction at 1.6 Å resolution. Released 13 Apr 2016.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 2,586
Mol. weight: 35.28 kDa
Released: 13 Apr 2016

Explore 5AN4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5AN4 contains 19 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	20-22	3
β-strand	24-27	4	1
α-helix	35-38	4
β-strand	47-51	5	1
β-strand	54-58	5	1
β-strand	63-68	6	1
β-strand	72-77	6	1
α-helix	80-82	3
α-helix	87-89	3
α-helix	90-99	10
α-helix	106-115	10
α-helix	118-126	9
α-helix	137-145	9
α-helix	152-166	15
β-strand	169-173	5	2
β-strand	176-179	4	2
α-helix	180-183	4
α-helix	184-187	4
α-helix	192-198	7
α-helix	204-218	15
α-helix	222-230	9
α-helix	233-241	9
α-helix	248-258	11
α-helix	269-279	11
α-helix	293-307	15
α-helix	311-322	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
N-glycosylase/dna lyase	A	protein	312	HOMO SAPIENS	O15527 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5AN4_1 N-GLYCOSYLASE/DNA LYASE (chains A)
GHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEE
QLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVR
LLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPE
VEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVA
DCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYA
GWAQAVLFSADL

Primary citation

Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation. Zander, U., Hoffmann, G., Cornaciu, I. et al. Acta Crystallogr D Biol Crystallogr (2016) 72:454. DOI 10.1107/S2059798316000954 · PubMed

Other PDB entries of the same protein (UniProt O15527 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8XWC 1.45 Å, Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the substrate…
2XHI 1.55 Å, Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA…
8XWU 1.68 Å, Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the reaction…
8XXK 1.7 Å, Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the reaction…
8XXG 1.82 Å, Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the reaction…
9NZ8 1.85 Å, Crystal structure of human OGG1 in a DNA-free state
1M3Q 1.9 Å, Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine
6RLW 2.0 Å, Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487
7AYY 2.0 Å, Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator…
9NZ9 2.0 Å, Crystal structure of product-bound human OGG1(WT)
1LWY 2.01 Å, hOgg1 Borohydride-Trapped Intermediate without 8-oxoguanine
2NOH 2.01 Å, Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to…

Browse structure collections

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