5GIW: Humanin containing a D-isomerized serine residue

Solution NMR structure of Humanin containing a D-isomerized serine residue. Determined by solution NMR. Released 20 Jul 2016.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 186
Mol. weight: 2.69 kDa
Released: 20 Jul 2016

Explore 5GIW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5GIW contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain X: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	6-13	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Humanin	X	protein	24	Homo sapiens	Q8IVG9 (AlphaFold model)

Sequence of entity 1 (X), FASTA

>5GIW_1 Humanin (chains X)
MAPRGFSCLLLLTSEIDLPVKRRA

Primary citation

Solution NMR structure and inhibitory effect against amyloid-beta fibrillation of Humanin containing a d-isomerized serine residue. Alsanousi, N., Sugiki, T., Furuita, K. et al. Biochem Biophys Res Commun (2016) 477:647-653. DOI 10.1016/j.bbrc.2016.06.114 · PubMed

Other PDB entries of the same protein (UniProt Q8IVG9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7WVX 2.8 Å, Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2
1Y32 NMR structure of humanin in 30% TFE solution
2GD3 NMR structure of S14G-humanin in 30% TFE solution

Browse structure collections

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