5I50: OmoMYC

Structure of OmoMYC bound to double-stranded DNA. Determined by X-ray diffraction at 2.7 Å resolution. Released 26 Oct 2016.

Method: X-ray diffraction
Resolution: 2.7 Å
Organisms: Homo sapiens, synthetic construct
Chains: 4
Atoms: 2,462
Mol. weight: 41.58 kDa
Released: 26 Oct 2016

Explore 5I50 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5I50 contains 5 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	2-32	31
α-helix	35-37	3
α-helix	45-85	41

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	0-31	32
α-helix	45-85	41

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Myc proto-oncogene protein	A, B	protein	118	Homo sapiens	P01106 (AlphaFold model)
DNA (5'-d(pcpapcpcpcpgpgptpcpapcpgptpgpgpcpcptpapcpapc)-3')	C	DNA	22	synthetic construct
DNA (5'-d(pgptpgptpapgpgpcpcpapcpgptpgpapcpcpgpgpgptpg)-3')	D	DNA	22	synthetic construct

Sequence of entity 1 (A, B), FASTA

>5I50_1 Myc proto-oncogene protein (chains A, B)
MKHHHHHHPMSDYDIPTTENLYFQGAMATEENVKRRTHNVLERQRRNELKRSFFALRDQI
PELENNEKAPKVVILKKATAYILSVQAETQKLISEIDLLRKQNEQLKHKLEQLRNSCA

Sequence of entity 2 (C), FASTA

>5I50_2 DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3') (chains C)
CACCCGGTCACGTGGCCTACAC

Sequence of entity 3 (D), FASTA

>5I50_3 DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3') (chains D)
GTGTAGGCCACGTGACCGGGTG

Primary citation

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Jung, L.A., Gebhardt, A., Koelmel, W. et al. Oncogene (2017) 36:1911-1924. DOI 10.1038/onc.2016.354 · PubMed

Other PDB entries of the same protein (UniProt P01106 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9QNH 1.3 Å, Myc pS294 phosphopeptide binding to 14-3-3sigma
6G6K 1.35 Å, The crystal structures of Human MYC:MAX bHLHZip complex
1NKP 1.8 Å, Crystal structure of Myc-Max recognizing DNA
8Q1N 1.84 Å, Cyclic peptide binder of the WBM-site of WDR5
4Y7R 1.9 Å, Crystal structure of WDR5 in complex with MYC MbIIIb peptide
8J2Q 1.92 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
5I4Z 1.95 Å, Structure of apo OmoMYC
8X8V 2.0 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
8X8S 2.04 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
1EE4 2.1 Å, Crystal structure of yeast karyopherin (importin) alpha in a complex with a C-myc nls…
6G6L 2.2 Å, The crystal structures of Human MYC:MAX bHLHZip complex
6G6J 2.25 Å, The crystal structures of Human MYC:MAX bHLHZip complex

Browse structure collections

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