Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with dasatinib. Determined by X-ray diffraction at 1.23 Å resolution. Released 9 Nov 2016.
Explore 5I9Y in 3D Show helices and sheets RCSB PDB PDBe
5I9Y contains 22 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 601-604 | 4 | |
| α-helix | 606 | 1 | |
| β-strand | 607 | 1 | 1 |
| α-helix | 608-609 | 2 | |
| α-helix | 610-612 | 3 | |
| β-strand | 613-621 | 9 | 1 |
| β-strand | 626-632 | 7 | 1 |
| β-strand | 641-648 | 8 | 1 |
| α-helix | 654-667 | 14 | |
| β-strand | 675 | 1 | 2 |
| α-helix | 676-677 | 2 | |
| β-strand | 678-682 | 5 | 1 |
| β-strand | 688-693 | 6 | 1 |
| β-strand | 698-699 | 2 | 2 |
| α-helix | 700-706 | 7 | |
| α-helix | 713-732 | 20 | |
| α-helix | 742-744 | 3 | |
| β-strand | 745-747 | 3 | 2 |
| β-strand | 753-755 | 3 | 2 |
| α-helix | 761-766 | 6 | |
| α-helix | 781-783 | 3 | |
| α-helix | 786-791 | 6 | |
| α-helix | 796-811 | 16 | |
| α-helix | 815-816 | 2 | |
| α-helix | 823-831 | 9 | |
| α-helix | 836-839 | 4 | |
| β-strand | 843 | 1 | 3 |
| α-helix | 844-853 | 10 | |
| α-helix | 858-860 | 3 | |
| α-helix | 862-863 | 2 | |
| α-helix | 864-876 | 13 | |
| α-helix | 878-882 | 5 | |
| β-strand | 884 | 1 | 3 |
| α-helix | 885-887 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ephrin type-A receptor 2 | A | protein | 306 | Homo sapiens | P29317 (AlphaFold model) |
>5I9Y_1 Ephrin type-A receptor 2 (chains A) GDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTE KQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVL QLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTT SGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGF RLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIR LPSTSG
| ID | Name | Formula | Copies |
|---|---|---|---|
| 1N1 | N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpy… | C22 H26 Cl N7 O2 S | 1 |
Water and common crystallization additives (EDO) are not listed.
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. Heinzlmeir, S., Kudlinzki, D., Sreeramulu, S. et al. ACS Chem Biol (2016) 11:3400-3411. DOI 10.1021/acschembio.6b00709 · PubMed
Other PDB entries of the same protein (UniProt P29317 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 5I9Y directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.