5IO9: N-terminal domain of human doublecortin

X-ray structure of the N-terminal domain of human doublecortin. Determined by X-ray diffraction at 1.3 Å resolution. Released 23 Mar 2016.

Method: X-ray diffraction
Resolution: 1.3 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,863
Mol. weight: 24.41 kDa
Released: 23 Mar 2016

Explore 5IO9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5IO9 contains 8 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	133	1
β-strand	134-140	7	1
β-strand	149-153	5	1
α-helix	161-172	12
β-strand	184-187	4	1
β-strand	193-194	2	1
α-helix	197-199	3
β-strand	205-209	5	1
α-helix	213-215	3

Chain B: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	134-140	7	2
β-strand	149-153	5	2
α-helix	161-172	12
β-strand	184-187	4	2
β-strand	193-194	2	2
α-helix	197-199	3
β-strand	205-209	5	2
α-helix	213-215	3
α-helix	227-229	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neuronal migration protein doublecortin	A, B	protein	106	Homo sapiens	O43602 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>5IO9_1 Neuronal migration protein doublecortin (chains A, B)
LVPRGSHMAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRY
IYTIDGSRKIGSMDELEEGESYVCSSDNFFDDVEYTKNVNPNWSVN

Primary citation

Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies. Burger, D., Stihle, M., Sharma, A. et al. J Biol Chem (2016) 291:16292-16306. DOI 10.1074/jbc.M116.726547 · PubMed

Other PDB entries of the same protein (UniProt O43602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5IP4 1.81 Å, X-ray structure of the C-terminal domain of human doublecortin
5IKC 2.06 Å, X-RAY STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN in complex with FAB
2BQQ 2.2 Å, X-ray Structure of the N-terminal Domain of Human Doublecortin
6FNZ 2.23 Å, Crystal Structure of domain-swapped C-terminal domain of human doublecortin
5IOI 2.4 Å, X-ray structure of the N-terminal domain of human doublecortin
5IN7 2.48 Å, X-ray structure of the N-terminal domain of human doublecortin
6REV 3.8 Å, Cryo-EM structure of the N-terminal DC repeat (NDC) of human doublecortin (DCX) bound to…
6RF8 3.8 Å, Cryo-EM structure of the N-terminal DC repeat (NDC) of NDC-NDC chimera (human sequence)…
6RFD 3.9 Å, Cryo-EM structure of the N-terminal DC repeat (NDC) of NDC-NDC chimera (human sequence)…
6RF2 4.2 Å, Cryo-EM structure of the C-terminal DC repeat (CDC) of human doublecortin (DCX) bound to…
2XRP 8.2 Å, Human Doublecortin N-DC Repeat (1MJD) and Mammalian Tubulin (1JFF and 3HKE) Docked into…
4ATU 8.3 Å, Human doublecortin N-DC repeat plus linker, and tubulin (2XRP) docked into an 8A cryo-EM…

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