5IY6: Human holo-PIC in the closed state

Human holo-PIC in the closed state. Determined by electron microscopy at 7.2 Å resolution. Released 18 May 2016.

Method: Electron microscopy
Resolution: 7.2 Å
Organism: Homo sapiens
Chains: 29
Atoms: 61,839
Mol. weight: 1203.9 kDa
Ligands: MG, ZN
Released: 18 May 2016

Explore 5IY6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5IY6 contains 359 α-helices and 333 β-strands across 27 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 8 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	59-66	8	93
α-helix	69-72	4
α-helix	80-98	19
β-strand	102-110	9	93
β-strand	113-121	9	93
α-helix	124-135	12
α-helix	145-157	13
β-strand	164-171	8	93
α-helix	182-192	11
β-strand	194-201	8	93
α-helix	206-215	10
β-strand	218-222	5	93
α-helix	225-236	12
α-helix	238-240	3

Chain 1: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	4-12	9	94
α-helix	18-25	8
β-strand	35-37	3	94
β-strand	43-46	4	94
α-helix	50-60	11

Chain 2: 18 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	29-44	16
α-helix	52-61	10
α-helix	77-83	7
α-helix	89-100	12
α-helix	118-128	11
α-helix	130-140	11
α-helix	160-176	17
α-helix	181-184	4
α-helix	188-198	11
α-helix	204-220	17
α-helix	229-232	4
α-helix	233-239	7
α-helix	240-247	8
α-helix	252-267	16
α-helix	391-398	8
β-strand	405-411	7	94
α-helix	416-427	12
β-strand	434-436	3	94
β-strand	441-445	5	94
α-helix	446-448	3
α-helix	449-455	7

Chain 3: 12 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	8-16	9	29
α-helix	21-24	4
α-helix	34-51	18
β-strand	55-62	8	29
β-strand	67-71	5	29
α-helix	101-103	3
α-helix	104-118	15
α-helix	125-127	3
α-helix	133-153	21
β-strand	157-165	9	29
α-helix	173-187	15
β-strand	191-195	5	29
α-helix	201-210	10
β-strand	214-216	3	29
α-helix	217	1
α-helix	220-222	3
α-helix	223-225	3
α-helix	226-230	5

Chain A: 77 helices, 65 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15-16	2	1
β-strand	20-22	3	2
β-strand	25	1	3
α-helix	28-34	7
β-strand	71	1	4
β-strand	73	1	4
β-strand	86-95	10	5
α-helix	97-109	13
β-strand	110	1	6
β-strand	117	1	6
α-helix	124-131	8
α-helix	137-149	13
β-strand	153	1	7
α-helix	186	1
β-strand	187	1	7
α-helix	188-189	2
β-strand	190-194	5	8
β-strand	197-204	8	8
β-strand	208-215	8	8
α-helix	216-217	2
α-helix	218-227	10
α-helix	230-236	7
β-strand	239	1	9
β-strand	243	1	9
α-helix	245-248	4
β-strand	249-255	7	5
α-helix	256-257	2
α-helix	275-295	21
α-helix	301-318	18
α-helix	334-336	3
α-helix	339-344	6
α-helix	350-354	5
β-strand	357-359	3	10
β-strand	362-366	5	11
β-strand	367-369	3	12
β-strand	377-381	5	11
α-helix	382-387	6
β-strand	389-393	5	13
α-helix	394	1
α-helix	399-408	10
α-helix	409-411	3
β-strand	416-420	5	13
β-strand	426-428	3	13
β-strand	445-449	5	13
α-helix	450	1
β-strand	455-459	5	11
α-helix	466-468	3
β-strand	469-477	9	11
β-strand	482-484	3	12
α-helix	486-492	7
β-strand	500-504	5	11
α-helix	509-514	6
α-helix	515-519	5
β-strand	520	1	11
α-helix	521-525	5
β-strand	526-527	2	14
β-strand	532-533	2	14
α-helix	540-548	9
β-strand	554-555	2	15
α-helix	557-566	10
α-helix	574-577	4
β-strand	579	1	16
β-strand	585	1	16
β-strand	586-587	2	15
α-helix	588-595	8
β-strand	603-604	2	17
β-strand	628-631	4	17
β-strand	634-637	4	17
α-helix	642-645	4
α-helix	652-659	8
α-helix	661-683	23
α-helix	689-692	4
α-helix	696-721	26
α-helix	725-728	4
α-helix	733-759	27
α-helix	765-772	8
α-helix	778-781	4
α-helix	782-786	5
β-strand	789-790	2	18
β-strand	792-793	2	19
β-strand	796-797	2	19
α-helix	798-799	2
α-helix	811	1
α-helix	818-820	3
β-strand	822-823	2	18
α-helix	833-868	36
β-strand	871-873	3	20
β-strand	879-881	3	20
β-strand	886-888	3	20
α-helix	891-893	3
β-strand	896	1	21
α-helix	898-900	3
β-strand	901-905	5	22
α-helix	913-920	8
α-helix	939-942	4
α-helix	946-969	24
β-strand	976-980	5	22
α-helix	983-994	12
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1052	2
α-helix	1053-1057	5
α-helix	1062-1079	18
β-strand	1080	1	21
α-helix	1081-1082	2
α-helix	1087-1099	13
α-helix	1121-1128	8
β-strand	1139-1141	3	23
β-strand	1143	1	24
α-helix	1151-1161	11
β-strand	1164-1165	2	25
α-helix	1166-1169	4
β-strand	1170-1177	8	26
α-helix	1187-1195	9
β-strand	1210-1216	7	26
α-helix	1218-1224	7
α-helix	1228-1239	12
β-strand	1243-1247	5	26
β-strand	1255-1261	7	26
α-helix	1281-1295	15
β-strand	1297-1299	3	25
β-strand	1309-1312	4	23
α-helix	1313-1315	3
β-strand	1321-1322	2	27
β-strand	1328-1329	2	27
β-strand	1334-1338	5	23
α-helix	1343-1348	6
β-strand	1352	1	24
β-strand	1358-1359	2	23
α-helix	1362-1368	7
α-helix	1371-1389	19
α-helix	1395-1406	12
α-helix	1416-1421	6
α-helix	1426-1431	6
α-helix	1436-1445	10
β-strand	1448-1449	2	2
α-helix	1455-1459	5
α-helix	1463-1464	2
β-strand	1471-1475	5	28
α-helix	1477-1483	7

Chain B: 52 helices, 78 β-strands

Element	Residues	Length	Sheet
α-helix	25-36	12
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
β-strand	65-68	4	30
β-strand	83-93	11	30
α-helix	94-95	2
β-strand	97-99	3	31
β-strand	105-107	3	31
α-helix	110-115	6
β-strand	121-132	12	30
β-strand	141-153	13	30
α-helix	162-165	4
α-helix	168-173	6
β-strand	185-187	3	32
β-strand	190-194	5	32
α-helix	195	1
β-strand	196-200	5	33
α-helix	201	1
β-strand	206-208	3	34
β-strand	215-222	8	34
β-strand	234-240	7	34
β-strand	258-259	2	34
β-strand	267	1	34
α-helix	269-276	8
α-helix	281-288	8
α-helix	295-308	14
α-helix	314-325	12
α-helix	332-341	10
α-helix	342-346	5
α-helix	349-351	3
α-helix	357-377	21
α-helix	381-384	4
β-strand	391-394	4	33
α-helix	396-425	30
α-helix	431-434	4
α-helix	437-450	14
α-helix	461-463	3
β-strand	467-469	3	32
α-helix	470-471	2
α-helix	475-483	9
β-strand	484-486	3	33
α-helix	503-505	3
β-strand	509	1	35
β-strand	520	1	36
β-strand	523	1	36
β-strand	524-525	2	33
β-strand	526	1	35
β-strand	531-532	2	37
α-helix	539-548	10
α-helix	558-561	4
β-strand	565-569	5	38
β-strand	572-577	6	38
α-helix	580-592	13
β-strand	602-606	5	38
β-strand	611-615	5	38
β-strand	621-627	7	37
β-strand	628-629	2	39
β-strand	632-633	2	39
α-helix	637-648	12
α-helix	653-659	7
β-strand	662-666	5	37
α-helix	667-670	4
β-strand	675-676	2	37
α-helix	679-682	4
β-strand	695-696	2	37
α-helix	700-703	4
α-helix	714-716	3
β-strand	717	1	40
α-helix	719-731	13
β-strand	732	1	41
β-strand	748-751	4	42
β-strand	759-760	2	43
α-helix	763-766	4
β-strand	775-782	8	44
β-strand	793-797	5	44
α-helix	798-803	6
β-strand	808-817	10	42
β-strand	820	1	45
β-strand	826	1	45
β-strand	829	1	46
β-strand	838	1	47
β-strand	848	1	48
β-strand	853	1	49
β-strand	854	1	48
α-helix	855	1
β-strand	859-860	2	42
β-strand	865-867	3	49
β-strand	869	1	46
β-strand	870-871	2	47
β-strand	890-891	2	47
β-strand	894-895	2	49
β-strand	902-911	10	42
β-strand	917-927	11	42
β-strand	934-937	4	44
β-strand	942-949	8	44
β-strand	956	1	50
β-strand	965-967	3	44
α-helix	971-975	5
β-strand	977	1	40
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	43
α-helix	1009-1017	9
β-strand	1025-1026	2	51
β-strand	1029	1	50
α-helix	1035	1
β-strand	1036	1	50
α-helix	1037	1
β-strand	1041-1042	2	51
β-strand	1043-1050	8	44
β-strand	1051	1	41
α-helix	1055-1058	4
β-strand	1060-1062	3	11
β-strand	1067-1068	2	52
β-strand	1073-1074	2	52
α-helix	1075	1
α-helix	1078-1080	3
β-strand	1084-1086	3	10
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1114-1119	6	1
β-strand	1122	1	1
β-strand	1137	1	53
β-strand	1142	1	53
β-strand	1146-1151	6	1
α-helix	1153-1164	12
β-strand	1167	1	3
β-strand	1170-1172	3	2

Chain C: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	9-14	6	54
β-strand	18-23	6	54
α-helix	28-36	9
α-helix	37-41	5
β-strand	43-55	13	55
α-helix	61-70	10
α-helix	79-81	3
α-helix	83-84	2
β-strand	98-106	9	55
α-helix	112	1
β-strand	113-116	4	56
α-helix	117-119	3
β-strand	120-122	3	55
β-strand	149-153	5	56
β-strand	158-169	12	55
α-helix	174-176	3
β-strand	179	1	57
β-strand	183-185	3	54
α-helix	200-202	3
α-helix	204-206	3
β-strand	229-234	6	54
β-strand	235	1	57
α-helix	241-269	29

Chain D: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	58
α-helix	17-19	3
β-strand	21	1	58
α-helix	24-27	4
α-helix	29	1
β-strand	30-31	2	28
α-helix	34-50	17
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-120	5
α-helix	124-137	14

19 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1970	Homo sapiens	P24928 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB2	B	protein	1174	Homo sapiens	P30876 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Homo sapiens	P19387 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4	D	protein	142	Homo sapiens	O15514 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB5	E	protein	210	Homo sapiens	P19388
DNA-directed RNA polymerase II subunit RPB6	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Homo sapiens	P62487
DNA-directed RNA polymerase II subunit RPB8	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Homo sapiens	P36954
DNA-directed RNA polymerase II subunit RPB10	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Homo sapiens	P52435
DNA-directed RNA polymerase II subunit RPB12	L	protein	58	Homo sapiens	P53803

17 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>5IY6_1 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>5IY6_2 DNA-directed RNA polymerase II subunit RPB2 (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>5IY6_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLISDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>5IY6_4 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>5IY6_5 DNA-directed RNA polymerase II subunit RPB5 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>5IY6_6 DNA-directed RNA polymerase II subunit RPB6 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 7 (G), FASTA

>5IY6_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>5IY6_8 DNA-directed RNA polymerase II subunit RPB8 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>5IY6_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>5IY6_10 DNA-directed RNA polymerase II subunit RPB10 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>5IY6_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>5IY6_12 DNA-directed RNA polymerase II subunit RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	2
ZN	Zinc ion	Zn	11

Primary citation

Near-atomic resolution visualization of human transcription promoter opening. He, Y., Yan, C., Fang, J. et al. Nature (2016) 533:359-365. DOI 10.1038/nature17970 · PubMed

Other PDB entries of the same protein (UniProt P24928 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6G0R 1.25 Å, Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated…
7Z1K 1.55 Å, Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA…
3D9N 1.6 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
6XKB 1.6 Å, Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide…
6IC9 1.75 Å, Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD…
3D9M 1.75 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
2GHT 1.8 Å, CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA…
4JXT 1.9 Å, CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD
6IC8 1.93 Å, Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD…
3D9O 2.0 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
2GHQ 2.05 Å, CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA…
3D9P 2.1 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…

Browse structure collections

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