5IY7: Human holo-PIC in the open state

Human holo-PIC in the open state. Determined by electron microscopy at 8.6 Å resolution. Released 18 May 2016.

Method: Electron microscopy
Resolution: 8.6 Å
Organism: Homo sapiens
Chains: 29
Atoms: 62,705
Mol. weight: 1211.33 kDa
Ligands: ZN, MG
Released: 18 May 2016

Explore 5IY7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5IY7 contains 365 α-helices and 326 β-strands across 27 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 8 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	59-66	8	89
α-helix	69-72	4
α-helix	80-98	19
β-strand	102-110	9	89
β-strand	113-121	9	89
α-helix	124-135	12
α-helix	145-157	13
β-strand	164-171	8	89
α-helix	182-192	11
β-strand	194-201	8	89
α-helix	206-215	10
β-strand	218-222	5	89
α-helix	225-236	12
α-helix	238-240	3

Chain 1: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	4-12	9	90
α-helix	18-25	8
β-strand	35-37	3	90
β-strand	43-46	4	90
α-helix	50-60	11

Chain 2: 18 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	29-44	16
α-helix	52-61	10
α-helix	77-83	7
α-helix	89-100	12
α-helix	118-128	11
α-helix	130-140	11
α-helix	160-176	17
α-helix	181-184	4
α-helix	188-198	11
α-helix	204-220	17
α-helix	229-232	4
α-helix	233-239	7
α-helix	240-247	8
α-helix	252-267	16
α-helix	391-398	8
β-strand	405-411	7	90
α-helix	416-427	12
β-strand	434-436	3	90
β-strand	441-445	5	90
α-helix	446-448	3
α-helix	449-455	7

Chain 3: 12 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	8-16	9	29
α-helix	21-24	4
α-helix	34-51	18
β-strand	55-62	8	29
β-strand	67-71	5	29
α-helix	101-103	3
α-helix	104-118	15
α-helix	125-127	3
α-helix	133-153	21
β-strand	157-165	9	29
α-helix	173-187	15
β-strand	191-195	5	29
α-helix	201-210	10
β-strand	214-216	3	29
α-helix	217	1
α-helix	220-222	3
α-helix	223-225	3
α-helix	226-230	5

Chain A: 80 helices, 65 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-23	4	2
α-helix	25-27	3
α-helix	28-34	7
β-strand	71	1	3
β-strand	73	1	3
β-strand	86-95	10	4
α-helix	100-109	10
β-strand	110	1	5
α-helix	111	1
β-strand	117	1	5
α-helix	124-131	8
α-helix	137-150	14
α-helix	186-189	4
β-strand	192-194	3	6
β-strand	197-200	4	6
β-strand	214-215	2	6
α-helix	216-217	2
α-helix	218-226	9
α-helix	230-235	6
α-helix	245-248	4
β-strand	249-255	7	4
α-helix	275-295	21
α-helix	301-318	18
β-strand	328	1	7
β-strand	329	1	8
β-strand	335	1	8
α-helix	336	1
α-helix	339-343	5
α-helix	350-354	5
β-strand	362-369	8	9
β-strand	377-381	5	9
α-helix	382-387	6
β-strand	389-393	5	10
α-helix	394	1
α-helix	399-407	9
β-strand	416-420	5	10
β-strand	426-428	3	10
α-helix	435-437	3
β-strand	442	1	11
β-strand	444	1	11
β-strand	445-449	5	10
α-helix	450	1
β-strand	455-459	5	9
α-helix	466-468	3
β-strand	469-477	9	9
β-strand	482-484	3	9
α-helix	486-488	3
α-helix	489-492	4
β-strand	500-504	5	9
α-helix	509-514	6
α-helix	515-519	5
β-strand	520	1	9
α-helix	521-524	4
β-strand	526	1	12
β-strand	533	1	12
α-helix	539-549	11
β-strand	554-555	2	13
α-helix	557-566	10
α-helix	573-577	5
β-strand	579-581	3	14
β-strand	585	1	14
β-strand	586-587	2	13
α-helix	588-595	8
β-strand	629-631	3	15
β-strand	634-637	4	15
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
β-strand	686	1	16
α-helix	696-721	26
α-helix	733-759	27
α-helix	765-771	7
α-helix	778-781	4
α-helix	782-786	5
β-strand	789-790	2	17
β-strand	793	1	18
β-strand	796	1	18
β-strand	802	1	19
β-strand	805	1	19
α-helix	811	1
α-helix	818-820	3
β-strand	822-823	2	17
α-helix	833-868	36
β-strand	872	1	20
β-strand	880	1	20
β-strand	886	1	20
α-helix	891-893	3
β-strand	896	1	21
β-strand	902-905	4	22
α-helix	907-909	3
α-helix	913-920	8
α-helix	922-923	2
β-strand	936	1	23
α-helix	939-942	4
α-helix	946-969	24
β-strand	976-979	4	22
α-helix	983-994	12
β-strand	1002	1	23
α-helix	1006-1019	14
α-helix	1028-1036	9
α-helix	1039-1048	10
α-helix	1051-1052	2
α-helix	1053-1058	6
α-helix	1062-1079	18
β-strand	1080	1	21
α-helix	1081-1082	2
α-helix	1087-1099	13
α-helix	1121-1128	8
β-strand	1138-1142	5	24
β-strand	1143	1	25
α-helix	1145-1148	4
α-helix	1151-1161	11
α-helix	1166-1169	4
β-strand	1170-1177	8	26
α-helix	1181-1183	3
α-helix	1187-1189	3
α-helix	1190-1195	6
α-helix	1203-1205	3
β-strand	1210-1216	7	26
α-helix	1218-1223	6
α-helix	1228-1239	12
β-strand	1245-1247	3	26
β-strand	1255-1259	5	26
α-helix	1265-1267	3
α-helix	1281-1295	15
β-strand	1308-1312	5	24
β-strand	1320	1	27
β-strand	1330	1	27
β-strand	1334-1339	6	24
α-helix	1343-1348	6
β-strand	1352	1	25
β-strand	1358-1359	2	24
α-helix	1363-1369	7
α-helix	1371-1388	18
α-helix	1395-1406	12
α-helix	1419-1421	3
α-helix	1426-1430	5
α-helix	1436-1445	10
β-strand	1448-1449	2	2
α-helix	1454-1460	7
α-helix	1468-1470	3
β-strand	1472-1475	4	28
α-helix	1477-1483	7

Chain B: 60 helices, 72 β-strands

Element	Residues	Length	Sheet
α-helix	23-25	3
α-helix	26-36	11
α-helix	41-49	9
α-helix	50-55	6
α-helix	56-60	5
β-strand	65-68	4	30
β-strand	83-93	11	30
α-helix	94	1
α-helix	96	1
β-strand	97-99	3	31
β-strand	105-107	3	31
α-helix	110-116	7
β-strand	121-131	11	30
β-strand	142-153	12	30
β-strand	155	1	32
α-helix	162-165	4
α-helix	168-173	6
β-strand	185-187	3	32
β-strand	190-194	5	32
α-helix	195	1
β-strand	196-200	5	33
β-strand	205-209	5	34
β-strand	215-221	7	34
β-strand	236-240	5	34
β-strand	257-259	3	34
β-strand	267-268	2	34
α-helix	269-275	7
α-helix	281-289	9
α-helix	295-308	14
α-helix	309-311	3
α-helix	314-325	12
α-helix	327-328	2
α-helix	332-341	10
α-helix	342-346	5
α-helix	349-351	3
α-helix	355-357	3
α-helix	358-377	20
α-helix	381-384	4
α-helix	388-390	3
β-strand	391-394	4	33
α-helix	396-425	30
α-helix	437-450	14
α-helix	461-463	3
β-strand	467-469	3	32
α-helix	475-482	8
β-strand	484-486	3	33
α-helix	503-505	3
β-strand	509	1	35
β-strand	523-525	3	33
β-strand	526	1	35
β-strand	531-532	2	36
α-helix	539-548	10
α-helix	550	1
β-strand	551-552	2	37
α-helix	553-555	3
α-helix	558-560	3
β-strand	565-569	5	37
β-strand	572-577	6	37
α-helix	580-592	13
α-helix	598-600	3
β-strand	602-606	5	37
α-helix	607-609	3
β-strand	611-615	5	37
β-strand	621-627	7	36
β-strand	628-629	2	38
β-strand	632-633	2	38
α-helix	637-644	8
α-helix	645-647	3
α-helix	653-658	6
β-strand	662-666	5	36
α-helix	667-670	4
β-strand	675-676	2	36
α-helix	679-684	6
β-strand	695-696	2	36
α-helix	700-703	4
α-helix	707-710	4
α-helix	714-716	3
β-strand	717	1	39
α-helix	720-731	12
β-strand	732	1	40
α-helix	739-741	3
β-strand	747-751	5	41
β-strand	755	1	42
α-helix	762-766	5
β-strand	775-782	8	43
β-strand	783	1	16
β-strand	794-797	4	43
α-helix	798-802	5
β-strand	808-817	10	41
β-strand	826-829	4	44
β-strand	837-838	2	44
β-strand	841	1	45
β-strand	853	1	46
β-strand	859	1	41
β-strand	865-867	3	46
β-strand	869-872	4	44
β-strand	889-891	3	44
β-strand	894-895	2	46
β-strand	903-911	9	41
β-strand	917-927	11	41
β-strand	931	1	47
β-strand	933	1	47
β-strand	934-937	4	43
β-strand	943-944	2	43
β-strand	947-949	3	43
α-helix	955-956	2
β-strand	965-967	3	43
α-helix	971-975	5
β-strand	977	1	39
α-helix	979-993	15
α-helix	1007-1017	11
β-strand	1025-1026	2	43
β-strand	1029	1	48
α-helix	1035	1
β-strand	1036	1	48
α-helix	1037	1
β-strand	1041-1050	10	43
β-strand	1051	1	40
α-helix	1055-1058	4
β-strand	1060-1062	3	9
β-strand	1067	1	49
β-strand	1074	1	49
α-helix	1078-1080	3
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1114-1119	6	1
β-strand	1137	1	50
β-strand	1142	1	50
β-strand	1146-1151	6	1
α-helix	1153-1163	11
β-strand	1167-1170	4	2

Chain C: 6 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	51
β-strand	18-24	7	51
α-helix	28-40	13
β-strand	43-55	13	52
α-helix	61-70	10
β-strand	73	1	53
α-helix	79-81	3
β-strand	99-106	8	52
β-strand	113-115	3	54
β-strand	121-122	2	52
β-strand	130	1	53
β-strand	151-153	3	54
β-strand	158-169	12	52
β-strand	179-186	8	51
α-helix	200-202	3
α-helix	204-206	3
β-strand	229-235	7	51
α-helix	241-266	26

Chain D: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	55
α-helix	17-19	3
β-strand	21	1	55
α-helix	29	1
β-strand	30-32	3	28
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-119	4
α-helix	124-137	14

19 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1970	Homo sapiens	P24928 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB2	B	protein	1174	Homo sapiens	P30876 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Homo sapiens	P19387 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4	D	protein	142	Homo sapiens	O15514 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB5	E	protein	210	Homo sapiens	P19388
DNA-directed RNA polymerase II subunit RPB6	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Homo sapiens	P62487
DNA-directed RNA polymerase II subunit RPB8	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Homo sapiens	P36954
DNA-directed RNA polymerase II subunit RPB10	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Homo sapiens	P52435
DNA-directed RNA polymerase II subunit RPB12	L	protein	58	Homo sapiens	P53803

17 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>5IY7_1 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>5IY7_2 DNA-directed RNA polymerase II subunit RPB2 (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>5IY7_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLISDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>5IY7_4 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>5IY7_5 DNA-directed RNA polymerase II subunit RPB5 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>5IY7_6 DNA-directed RNA polymerase II subunit RPB6 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 7 (G), FASTA

>5IY7_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>5IY7_8 DNA-directed RNA polymerase II subunit RPB8 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>5IY7_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>5IY7_10 DNA-directed RNA polymerase II subunit RPB10 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>5IY7_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>5IY7_12 DNA-directed RNA polymerase II subunit RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	11
MG	Magnesium ion	Mg	2

Primary citation

Near-atomic resolution visualization of human transcription promoter opening. He, Y., Yan, C., Fang, J. et al. Nature (2016) 533:359-365. DOI 10.1038/nature17970 · PubMed

Other PDB entries of the same protein (UniProt P24928 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6G0R 1.25 Å, Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated…
7Z1K 1.55 Å, Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA…
3D9N 1.6 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
6XKB 1.6 Å, Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide…
6IC9 1.75 Å, Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD…
3D9M 1.75 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
2GHT 1.8 Å, CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA…
4JXT 1.9 Å, CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD
6IC8 1.93 Å, Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD…
3D9O 2.0 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
2GHQ 2.05 Å, CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA…
3D9P 2.1 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…

Browse structure collections

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