5IYD: Human core-PIC in the initial transcribing state

Human core-PIC in the initial transcribing state (no IIS). Determined by electron microscopy at 3.9 Å resolution. Released 18 May 2016.

Method: Electron microscopy
Resolution: 3.9 Å
Organism: Homo sapiens
Chains: 23
Atoms: 46,709
Mol. weight: 865.37 kDa
Ligands: MG, ZN
Released: 18 May 2016

Explore 5IYD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5IYD contains 240 α-helices and 254 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 75 helices, 61 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	20-22	3	2
β-strand	25	1	3
α-helix	28-34	7
β-strand	86-95	10	4
α-helix	100-109	10
β-strand	110	1	5
α-helix	111	1
β-strand	117	1	5
α-helix	124-131	8
α-helix	137-151	15
β-strand	192-194	3	6
β-strand	197-199	3	6
β-strand	215	1	6
α-helix	218-227	10
α-helix	230-235	6
α-helix	245-248	4
β-strand	249-255	7	4
α-helix	275-295	21
α-helix	300-318	19
α-helix	326-327	2
β-strand	328-330	3	7
β-strand	334-335	2	7
α-helix	339-344	6
α-helix	351-355	5
β-strand	358-359	2	8
β-strand	362-369	8	9
β-strand	377-381	5	9
α-helix	382-387	6
β-strand	389-393	5	10
α-helix	394	1
α-helix	399-408	10
α-helix	409-411	3
β-strand	416-420	5	10
β-strand	426-428	3	10
α-helix	435-437	3
β-strand	445-449	5	10
β-strand	455-459	5	9
α-helix	466-468	3
β-strand	469-477	9	9
β-strand	482-484	3	9
α-helix	486-489	4
β-strand	500-504	5	9
α-helix	509-514	6
α-helix	515-519	5
α-helix	521-523	3
β-strand	526	1	11
β-strand	533	1	11
α-helix	539-549	11
β-strand	554-555	2	12
α-helix	557-566	10
α-helix	574-577	4
β-strand	579-581	3	13
β-strand	585	1	13
β-strand	586-587	2	12
α-helix	588-595	8
α-helix	616-618	3
β-strand	629-631	3	14
β-strand	634-637	4	14
α-helix	642-645	4
α-helix	652-660	9
α-helix	662-683	22
β-strand	686	1	15
α-helix	689-692	4
α-helix	696-721	26
α-helix	727-728	2
α-helix	733-759	27
α-helix	765-772	8
α-helix	778-785	8
β-strand	789	1	16
β-strand	793	1	17
β-strand	796	1	17
β-strand	802	1	18
β-strand	805	1	18
α-helix	811	1
β-strand	823	1	16
α-helix	833-868	36
β-strand	872-873	2	19
β-strand	879-880	2	19
β-strand	886-888	3	19
α-helix	891-893	3
β-strand	896	1	20
β-strand	901-905	5	21
α-helix	913-920	8
α-helix	922-923	2
β-strand	936	1	22
α-helix	938-941	4
α-helix	946-969	24
β-strand	976-980	5	21
α-helix	983-994	12
α-helix	1001	1
β-strand	1002	1	22
α-helix	1006-1019	14
α-helix	1028-1048	21
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1079	18
β-strand	1080	1	20
α-helix	1088-1096	9
α-helix	1097-1100	4
α-helix	1121-1129	9
β-strand	1139-1142	4	23
β-strand	1143	1	24
α-helix	1145-1149	5
α-helix	1151-1161	11
α-helix	1166-1169	4
β-strand	1170-1177	8	25
α-helix	1181-1183	3
α-helix	1187-1189	3
α-helix	1190-1195	6
α-helix	1203-1205	3
β-strand	1210-1216	7	25
α-helix	1218-1223	6
α-helix	1228-1239	12
β-strand	1243-1247	5	25
β-strand	1255-1261	7	25
α-helix	1265-1267	3
α-helix	1281-1294	14
β-strand	1309-1313	5	23
β-strand	1320-1322	3	26
β-strand	1328-1330	3	26
β-strand	1333-1338	6	23
α-helix	1343-1347	5
β-strand	1352	1	24
β-strand	1358-1359	2	23
α-helix	1362-1369	8
α-helix	1371-1388	18
α-helix	1395-1406	12
α-helix	1416-1419	4
α-helix	1426-1430	5
α-helix	1436-1445	10
β-strand	1448-1449	2	2
α-helix	1454-1460	7
α-helix	1467-1470	4
β-strand	1471-1475	5	27
α-helix	1477-1483	7

Chain B: 54 helices, 75 β-strands

Element	Residues	Length	Sheet
α-helix	23-36	14
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-59	5
β-strand	65-68	4	28
β-strand	83-93	11	28
β-strand	97-99	3	29
β-strand	105-107	3	29
α-helix	110-115	6
β-strand	121-131	11	28
β-strand	142-153	12	28
α-helix	154	1
β-strand	155	1	30
α-helix	163-165	3
α-helix	168-174	7
β-strand	185-187	3	30
β-strand	190-194	5	30
β-strand	196-200	5	31
α-helix	201	1
β-strand	206-208	3	32
β-strand	215-222	8	32
β-strand	234-240	7	32
β-strand	255-259	5	32
β-strand	267-268	2	32
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-308	14
α-helix	314-325	12
α-helix	333-345	13
α-helix	349-351	3
α-helix	355-357	3
α-helix	358-377	20
α-helix	388-390	3
β-strand	391-394	4	31
α-helix	396-425	30
α-helix	431-434	4
α-helix	438-450	13
β-strand	467-469	3	30
α-helix	475-482	8
β-strand	484-486	3	31
α-helix	501-502	2
β-strand	509	1	33
β-strand	523-525	3	31
β-strand	526	1	33
β-strand	527	1	34
β-strand	531-532	2	35
α-helix	539-548	10
α-helix	550	1
β-strand	551-552	2	36
α-helix	553-555	3
β-strand	565-569	5	36
β-strand	572-577	6	36
α-helix	580-592	13
β-strand	602-606	5	36
α-helix	607-609	3
β-strand	611-615	5	36
β-strand	621-627	7	35
β-strand	628-629	2	37
β-strand	632-633	2	37
α-helix	637-645	9
α-helix	646-648	3
α-helix	653-658	6
β-strand	662-666	5	35
α-helix	669-671	3
β-strand	675-676	2	35
α-helix	679-684	6
β-strand	695-696	2	35
α-helix	700-703	4
β-strand	705	1	34
α-helix	707-709	3
α-helix	714-716	3
α-helix	719-731	13
β-strand	732	1	38
β-strand	734	1	39
α-helix	738-742	5
β-strand	747-751	5	39
β-strand	755	1	40
β-strand	759-760	2	41
α-helix	762-767	6
β-strand	775	1	40
β-strand	776-782	7	42
β-strand	783	1	15
β-strand	793-797	5	42
α-helix	798-802	5
β-strand	808-817	10	39
β-strand	826-829	4	43
β-strand	838	1	43
α-helix	845-847	3
β-strand	853	1	44
β-strand	859-861	3	39
β-strand	867	1	44
β-strand	869-872	4	43
β-strand	889-891	3	43
β-strand	894	1	44
β-strand	901-911	11	39
β-strand	917-927	11	39
β-strand	934-937	4	42
β-strand	941-949	9	42
β-strand	956-957	2	45
β-strand	965-967	3	42
α-helix	971-975	5
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	41
α-helix	1007-1018	12
β-strand	1025-1026	2	42
β-strand	1028-1029	2	45
α-helix	1030	1
α-helix	1035	1
β-strand	1036	1	45
α-helix	1037	1
β-strand	1041-1050	10	42
β-strand	1051	1	38
α-helix	1055-1058	4
β-strand	1060-1062	3	9
β-strand	1067	1	46
β-strand	1074	1	46
α-helix	1078-1080	3
β-strand	1084-1085	2	8
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1114-1119	6	1
β-strand	1137	1	47
β-strand	1142	1	47
β-strand	1146-1151	6	1
α-helix	1153-1164	12
β-strand	1167	1	3
β-strand	1170-1172	3	2

Chain C: 10 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	48
β-strand	18-24	7	48
α-helix	28-36	9
α-helix	37-41	5
β-strand	44-55	12	49
α-helix	61-68	8
β-strand	73	1	50
α-helix	79-81	3
β-strand	99-106	8	49
β-strand	113-116	4	51
α-helix	117-119	3
β-strand	121-122	2	49
β-strand	130	1	50
β-strand	149-153	5	51
β-strand	158-168	11	49
α-helix	174-176	3
β-strand	179-186	8	48
α-helix	200-202	3
α-helix	204-205	2
α-helix	209-212	4
β-strand	229-235	7	48
α-helix	241-268	28

Chain D: 11 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	52
α-helix	17-19	3
β-strand	21	1	52
α-helix	24-27	4
α-helix	29	1
β-strand	30-31	2	27
α-helix	34-51	18
α-helix	54-58	5
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-120	5
α-helix	124-137	14

Chain E: 12 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	2-24	23
α-helix	30-33	4
α-helix	37-43	7
α-helix	54-57	4
β-strand	60-62	3	53
β-strand	72-75	4	53
β-strand	81-82	2	54
α-helix	84-97	14
β-strand	101-106	6	53
β-strand	109-110	2	54
α-helix	112-121	10
β-strand	126-131	6	53
α-helix	132-135	4
α-helix	139-141	3
α-helix	145-146	2
β-strand	147-150	4	55
α-helix	153-163	11
α-helix	167-169	3
β-strand	172-173	2	55
α-helix	178-183	6
β-strand	190-196	7	55
β-strand	202-209	8	55

Chain F: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56-57	2	56
α-helix	58	1
α-helix	59-73	15
α-helix	77-79	3
α-helix	89-99	11
β-strand	104-109	6	27
β-strand	115-119	5	27
β-strand	124-125	2	56

Chain G: 2 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	27
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	27
β-strand	43-54	12	27
β-strand	57-59	3	27
β-strand	66-77	12	27
β-strand	84-93	10	57
β-strand	96-101	6	57
β-strand	104-109	6	57
β-strand	117-120	4	58
β-strand	127-130	4	58
β-strand	136-137	2	58
β-strand	142-153	12	57
β-strand	156-162	7	57
β-strand	169	1	57

Chain H: 0 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	13
β-strand	25-32	8	13
β-strand	38-44	7	13
β-strand	55-61	7	13
β-strand	90-100	11	13
β-strand	112-118	7	13
β-strand	121-127	7	13
β-strand	141-146	6	13

12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1970	Homo sapiens	P24928 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB2	B	protein	1174	Homo sapiens	P30876 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Homo sapiens	P19387 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4	D	protein	142	Homo sapiens	O15514 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB5	E	protein	210	Homo sapiens	P19388
DNA-directed RNA polymerase II subunit RPB6	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Homo sapiens	P62487
DNA-directed RNA polymerase II subunit RPB8	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Homo sapiens	P36954
DNA-directed RNA polymerase II subunit RPB10	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Homo sapiens	P52435
DNA-directed RNA polymerase II subunit RPB12	L	protein	58	Homo sapiens	P53803

11 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>5IYD_1 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>5IYD_2 DNA-directed RNA polymerase II subunit RPB2 (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>5IYD_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLISDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>5IYD_4 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>5IYD_5 DNA-directed RNA polymerase II subunit RPB5 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>5IYD_6 DNA-directed RNA polymerase II subunit RPB6 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 7 (G), FASTA

>5IYD_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>5IYD_8 DNA-directed RNA polymerase II subunit RPB8 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>5IYD_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>5IYD_10 DNA-directed RNA polymerase II subunit RPB10 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>5IYD_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>5IYD_12 DNA-directed RNA polymerase II subunit RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	2
ZN	Zinc ion	Zn	11

Primary citation

Near-atomic resolution visualization of human transcription promoter opening. He, Y., Yan, C., Fang, J. et al. Nature (2016) 533:359-365. DOI 10.1038/nature17970 · PubMed

Other PDB entries of the same protein (UniProt P24928 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6G0R 1.25 Å, Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated…
7Z1K 1.55 Å, Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA…
3D9N 1.6 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
6XKB 1.6 Å, Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide…
6IC9 1.75 Å, Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD…
3D9M 1.75 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
2GHT 1.8 Å, CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA…
4JXT 1.9 Å, CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD
6IC8 1.93 Å, Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD…
3D9O 2.0 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…
2GHQ 2.05 Å, CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA…
3D9P 2.1 Å, Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of…

Browse structure collections

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