5LGJ: IgE fc mutant - P333C

The crystal structure of IgE fc mutant - P333C. Determined by X-ray diffraction at 2.6 Å resolution. Released 15 Mar 2017.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 2
Atoms: 5,305
Mol. weight: 74.13 kDa
Released: 15 Mar 2017

Explore 5LGJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5LGJ contains 30 α-helices and 54 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	233-239	7	1
α-helix	240-241	2
α-helix	246-248	3
β-strand	250-259	11	1
β-strand	264-270	7	2
β-strand	273-274	2	2
α-helix	275-276	2
α-helix	277-279	3
β-strand	280-287	8	1
β-strand	290-300	11	1
α-helix	301-305	5
β-strand	310-316	7	2
β-strand	319-325	7	2
β-strand	338-340	3	3
α-helix	341-344	4
α-helix	345-349	5
β-strand	355-363	9	3
β-strand	371-376	6	4
α-helix	384-386	3
β-strand	388-391	4	3
β-strand	397-404	8	3
α-helix	407-411	5
β-strand	416-421	6	4
β-strand	429-433	5	4
β-strand	441	1	5
β-strand	444-449	6	6
α-helix	450-453	4
β-strand	459-469	11	6
β-strand	470	1	5
β-strand	475-480	6	7
β-strand	483-484	2	7
α-helix	485-486	2
α-helix	487-489	3
β-strand	490-492	3	6
α-helix	493-495	3
β-strand	496-497	2	6
β-strand	503-512	10	6
α-helix	513-518	6
β-strand	522-527	6	7
β-strand	536-541	6	7

Chain B: 16 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	233-239	7	1
α-helix	240-241	2
α-helix	246-248	3
β-strand	250-259	11	1
β-strand	264-270	7	8
β-strand	273-275	3	8
α-helix	276	1
α-helix	277-279	3
β-strand	280-284	5	1
β-strand	291-300	10	1
α-helix	301-305	5
β-strand	310-316	7	8
β-strand	319-325	7	8
α-helix	328-330	3
β-strand	337-340	4	9
α-helix	341-344	4
α-helix	345-346	2
α-helix	347-351	5
β-strand	355-363	9	9
β-strand	371-376	6	10
α-helix	380-382	3
β-strand	386-391	6	9
β-strand	397-404	8	9
α-helix	407-411	5
β-strand	416-421	6	10
β-strand	429-433	5	10
β-strand	441	1	11
β-strand	444-449	6	12
α-helix	450-452	3
β-strand	453	1	13
β-strand	456	1	13
β-strand	459-469	11	12
β-strand	470	1	11
β-strand	475-480	6	14
β-strand	483-484	2	14
α-helix	485-486	2
α-helix	487-489	3
β-strand	490-492	3	12
α-helix	493-495	3
β-strand	496-497	2	12
β-strand	503-512	10	12
α-helix	513-518	6
β-strand	522-527	6	14
β-strand	536-541	6	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ig epsilon chain C region	A	protein	319	Homo sapiens	P01854 (AlphaFold model)
Ig epsilon chain C region	B	protein	320	Homo sapiens	P01854 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5LGJ_1 Ig epsilon chain C region (chains A)
DFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTIQITWLEDGQVMDVDLSTASTTQ
EGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNCRGVSAYLSRPSPF
DLFIRKSPTITCLVVDLAPSKGTVQLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVG
TRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLI
QNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRA
VHEAASPSQTVQRAVSVNP

Sequence of entity 2 (B), FASTA

>5LGJ_2 Ig epsilon chain C region (chains B)
DFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTIQITWLEDGQVMDVDLSTASTTQ
EGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNCRGVSAYLSRPSPF
DLFIRKSPTITCLVVDLAPSKGTVQLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVG
TRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLI
QNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRA
VHEAASPSQTVQRAVSVNPG

Primary citation

THE CRYSTAL STRUCTURE OF IGE FC MUTANT - P333C. Dhaliwal, B., Pang, M.O.Y., Keeble, A.H. et al. To be published.

Other PDB entries of the same protein (UniProt P01854 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5MOL 1.75 Å, Human IgE-Fc crystal structure
2WQR 1.9 Å, The high resolution crystal structure of IgE Fc
5MOK 2.0 Å, Crystal structure of human IgE-Fc epsilon 3-4
5MOI 2.2 Å, Crystal structure of human IgE-Fc epsilon 3-4
3H9Y 2.23 Å, Crystal structure of the IgE-Fc3-4 domains
5MOJ 2.26 Å, Crystal structure of IgE-Fc epsilon 3-4
1FP5 2.3 Å, Crystal structure analysis of the human IgE-fc CEPSILON3-CEPSILON4 fragment.
30AF 2.4 Å, Complex between IgE-Fc and anti-IgE Fab aeFab98
3H9Z 2.45 Å, Crystal structure of the IgE-Fc3-4 domains
5HYS 2.5 Å, Structure of IgE complexed with omalizumab
1O0V 2.6 Å, The crystal structure of IgE Fc reveals an asymmetrically bent conformation
4GT7 2.61 Å, An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, non-receptor…

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