5LV0: Human Neurolysin

Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product. Determined by X-ray diffraction at 2.7 Å resolution. Released 6 Dec 2017.

Method
X-ray diffraction
Resolution
2.7 Å
Organism
Homo sapiens
Chains
4
Atoms
10,786
Mol. weight
158.61 kDa
Ligands
ZN
Released
6 Dec 2017

Explore 5LV0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5LV0 contains 82 α-helices and 32 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 40 helices, 16 β-strands

ElementResiduesLengthSheet
α-helix31-5424
α-helix57-593
α-helix62-665
α-helix67-8418
α-helix86-894
α-helix93-11422
α-helix117-12913
α-helix137-15216
α-helix159-18527
β-strand189-19241
α-helix202-2076
α-helix2091
β-strand21011
β-strand216-21941
α-helix222-23110
α-helix235-24511
α-helix250-27021
α-helix276-2816
α-helix289-32537
β-strand33412
α-helix338-35013
α-helix354-3574
α-helix358-3603
β-strand36213
α-helix363-37816
β-strand380-38564
β-strand396-40274
β-strand408-41584
β-strand427-43264
β-strand43615
β-strand44215
α-helix443-4442
β-strand445-45064
β-strand45716
β-strand46016
β-strand46313
α-helix466-48419
α-helix504-5107
α-helix511-5144
α-helix516-5227
α-helix530-5334
α-helix534-5429
α-helix543-5453
α-helix548-56518
α-helix573-5808
α-helix581-5855
β-strand58812
α-helix589-5902
α-helix596-5983
α-helix600-6023
α-helix612-62312
α-helix624-6285
α-helix636-6427
α-helix643-6475
α-helix655-6639
α-helix670-6767
Chain B: 42 helices, 14 β-strands
ElementResiduesLengthSheet
α-helix15-173
α-helix31-5424
α-helix62-676
α-helix68-8417
α-helix86-894
α-helix93-11422
α-helix117-12913
α-helix132-1343
α-helix137-15216
α-helix159-18426
β-strand189-19247
α-helix202-2076
β-strand21017
β-strand216-21947
α-helix222-23110
α-helix235-24511
α-helix250-27021
α-helix276-2816
α-helix289-32537
β-strand33418
α-helix335-35016
α-helix354-3574
α-helix358-3603
β-strand36219
α-helix363-37816
β-strand381-385510
β-strand396-401610
β-strand408-415810
β-strand427-432610
β-strand436111
α-helix4411
β-strand442111
α-helix443-4442
β-strand445-450610
β-strand46319
α-helix466-48419
α-helix490-4923
α-helix504-5107
α-helix511-5144
α-helix516-5227
α-helix530-5334
α-helix534-5429
α-helix543-5453
α-helix548-56518
α-helix573-5808
α-helix581-5855
β-strand58818
α-helix589-5902
α-helix596-5983
α-helix600-6034
α-helix612-62312
α-helix624-6285
α-helix636-6427
α-helix643-6475
α-helix655-6639
α-helix670-6745
Chains C and D: 0 helices, 1 β-strand
ElementResiduesLengthSheet
β-strand514

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Neurolysin, mitochondrialA, Bprotein686Homo sapiensQ9BYT8 (AlphaFold model)
GLY-VAL-VAL amyloid 35-40 fragmentC, Dprotein6Homo sapiensP05067 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>5LV0_1 Neurolysin, mitochondrial (chains A, B)
MGSSHHHHHHSSGLVPRGSSSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGML
GIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSM
RGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKKRMSEL
CIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDDKYKITLKYPHYFPVMKKCCIP
ETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAF
LDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQE
FLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLD
LYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLLRHDEVRTYFHQ
FGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADD
LLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEILGVAATPGTNM
PATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDG
MDMLHNFLKREPNQKAFLMSRGLHAP
Sequence of entity 2 (C, D), FASTA
>5LV0_2 GLY-VAL-VAL amyloid 35-40 fragment (chains C, D)
MVGGVV

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn2

Water and common crystallization additives (CL) are not listed.

Primary citation

Structural and functional analysis of Neurolysin, a new component of the mitochondrial peptidolytic network. Teixeira, P.F., Masuyer, G., Pinho, C. et al. To be published.

Other PDB entries of the same protein (UniProt Q9BYT8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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