Structure of human Myosin 7a C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain. Determined by X-ray diffraction at 2.6 Å resolution. Released 5 Jul 2017.
Explore 5MV9 in 3D Show helices and sheets RCSB PDB PDBe
5MV9 contains 33 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1708-1712 | 5 | |
| α-helix | 1715-1721 | 7 | |
| β-strand | 1722 | 1 | 1 |
| α-helix | 1723-1726 | 4 | |
| β-strand | 1757 | 1 | 1 |
| α-helix | 1758-1760 | 3 | |
| α-helix | 1764-1780 | 17 | |
| α-helix | 1794-1805 | 12 | |
| α-helix | 1808-1821 | 14 | |
| α-helix | 1827-1841 | 15 | |
| α-helix | 1845-1847 | 3 | |
| α-helix | 1851-1859 | 9 | |
| α-helix | 1867-1880 | 14 | |
| α-helix | 1886-1888 | 3 | |
| α-helix | 1889-1896 | 8 | |
| β-strand | 1902-1908 | 7 | 2 |
| β-strand | 1912-1918 | 7 | 2 |
| β-strand | 1923 | 1 | 3 |
| α-helix | 1924-1934 | 11 | |
| β-strand | 1943-1949 | 7 | 2 |
| β-strand | 1953-1955 | 3 | 2 |
| α-helix | 1956-1957 | 2 | |
| β-strand | 1961 | 1 | 3 |
| α-helix | 1962-1975 | 14 | |
| β-strand | 1989-1995 | 7 | 2 |
| α-helix | 2007-2008 | 2 | |
| α-helix | 2009-2014 | 6 | |
| α-helix | 2015-2024 | 10 | |
| α-helix | 2031-2046 | 16 | |
| α-helix | 2053-2055 | 3 | |
| α-helix | 2057-2059 | 3 | |
| α-helix | 2060-2063 | 4 | |
| α-helix | 2069-2071 | 3 | |
| α-helix | 2074-2085 | 12 | |
| α-helix | 2086-2088 | 3 | |
| α-helix | 2093-2104 | 12 | |
| β-strand | 2113-2119 | 7 | 4 |
| β-strand | 2128-2134 | 7 | 4 |
| β-strand | 2137-2141 | 5 | 4 |
| β-strand | 2148-2152 | 5 | 4 |
| α-helix | 2154-2156 | 3 | |
| β-strand | 2157-2162 | 6 | 4 |
| β-strand | 2166-2171 | 6 | 4 |
| β-strand | 2179-2183 | 5 | 4 |
| α-helix | 2187-2204 | 18 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 453-458 | 6 | 5 |
| β-strand | 466-471 | 6 | 5 |
| β-strand | 478-484 | 7 | 5 |
| α-helix | 490-493 | 4 | |
| α-helix | 500 | 1 | |
| β-strand | 501-505 | 5 | 5 |
| β-strand | 508-509 | 2 | 5 |
| α-helix | 515-527 | 13 | |
| β-strand | 533-538 | 6 | 5 |
| α-helix | 539-542 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Unconventional myosin-VIIa | A | protein | 527 | Homo sapiens | Q13402 (AlphaFold model) |
| cDNA FLJ51329, highly similar to Harmonin | B | protein | 130 | Homo sapiens | Q9Y6N9 (AlphaFold model) |
>5MV9_1 Unconventional myosin-VIIa (chains A) MGSSHHHHHHSSGTAEPEVRAKPYTLEEFSYDYFRPPPKHTLSRVMVSKARGKDRLWSHT REPLKQALLKKLLGSEELSQEACLAFIAVLKYMGDYPSKRTRSVNELTDQIFEGPLKAEP LKDEAYVQILKQLTDNHIRYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAI DCLQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFC QNIATRLLLKSSEGFSLFVKIADKVLSVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLT YQVFFMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEE DKSYFPSIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWP TFGSAFFEVKQTTEPNFPEILLIAINKYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFH ITIGNLVRGSKLLCETSLGYKMDDLLTSYISQMLTAMSKQRGSRSGK
>5MV9_2 cDNA FLJ51329, highly similar to Harmonin (chains B) GAMGSQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVS AVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPP KEYDDELTFF
Myosin 7 and its adaptors link cadherins to actin. Yu, I.M., Planelles-Herrero, V.J., Sourigues, Y. et al. Nat Commun (2017) 8:15864-15864. DOI 10.1038/ncomms15864 · PubMed
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