Harmonin (USH1C) is a 552-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y6N9.
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The mean pLDDT of this model is 79.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 46% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018)
Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (PubMed:24725409, PubMed:26812018, PubMed:32209652). Part of a complex composed of USH1C, USH1G and MYO7A (PubMed:21709241). Interacts with F-actin (By similarity). Interacts with USH2A (PubMed:16301216). Interacts with SLC4A7 (PubMed:16301216). Interacts (via…
Cytoplasm, cytosol, Cytoplasm, cytoskeleton, Cell projection, microvillus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5XBF | X-ray | 1.8 Å | B=428-552 |
| 7X2E | X-ray | 1.85 Å | A=193-370 |
| 5MV8 | X-ray | 1.88 Å | B=428-552 |
| 3K1R | X-ray | 2.3 Å | A=1-192 |
| 5MV9 | X-ray | 2.6 Å | B=428-552 |
| 5F3X | X-ray | 2.65 Å | A/C=1-194 |
| 1X5N | NMR | A=201-301 | |
| 2KBQ | NMR | A=1-80 | |
| 2KBR | NMR | A=1-80 | |
| 2KBS | NMR | A=208-299 | |
| 2LSR | NMR | A=1-80 |
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