5NJ8: Aryl hydrocarbon receptor

Structural basis for aryl hydrocarbon receptor mediated gene activation. Determined by X-ray diffraction at 3.3 Å resolution. Released 28 Jun 2017.

Method
X-ray diffraction
Resolution
3.3 Å
Organisms
Homo sapiens, Mus musculus
Chains
8
Atoms
5,848
Mol. weight
126.5 kDa
Ligands
ER3
Released
28 Jun 2017

Explore 5NJ8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5NJ8 contains 30 α-helices and 29 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix35-5218
α-helix58-614
α-helix66-8621
α-helix113-1219
β-strand126-13051
β-strand13412
β-strand135-13841
α-helix142-1465
α-helix150-1523
β-strand15712
α-helix158-1614
β-strand16211
α-helix164-17411
β-strand217-22481
β-strand235-246121
β-strand262-27091
Chain B: 7 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix87-11226
α-helix128-14215
α-helix161-17111
β-strand174-18073
β-strand186-18943
α-helix191-1933
α-helix209-2124
β-strand21313
α-helix215-2173
α-helix218-2225
β-strand260-26893
β-strand303-314123
β-strand335-34393
Chain C: 9 helices, 12 β-strands
ElementResiduesLengthSheet
α-helix35-5218
α-helix58-614
α-helix66-8722
α-helix110-12112
β-strand126-13054
β-strand13415
β-strand135-13844
α-helix142-1454
α-helix150-1534
β-strand15715
α-helix158-1614
β-strand16216
α-helix164-1729
β-strand21814
β-strand221-22227
β-strand22416
β-strand237-23827
β-strand240-24124
β-strand244-24524
α-helix260-2623
β-strand263-26864
Chain D: 6 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix87-11529
α-helix117-1204
α-helix125-1273
α-helix128-14215
α-helix161-17212
α-helix191-1933
β-strand26318
β-strand308-31148
β-strand338-34148

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Aryl hydrocarbon receptorA, Cprotein254Homo sapiensP35869 (AlphaFold model)
Aryl hydrocarbon receptor nuclear translocatorB, Dprotein239Mus musculusP27540 (AlphaFold model)
DNA (5'-d(*gp*gp*tp*cp*ap*cp*gp*cp*ap*ap*cp*c)-3')E, GDNA12Homo sapiens
DNA (5'-d(*gp*gp*tp*tp*gp*cp*gp*tp*gp*ap*cp*c)-3')F, HDNA12Homo sapiens
Sequence of entity 1 (A, C), FASTA
>5NJ8_1 Aryl hydrocarbon receptor (chains A, C)
GPMVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRA
KSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYAS
STIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQT
VVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSIL
PPQLALFAIATPLQ
Sequence of entity 2 (B, D), FASTA
>5NJ8_2 Aryl hydrocarbon receptor nuclear translocator (chains B, D)
GPGSDADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH
MKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN
QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRVLDLKTGTVKKEGQQSSMRMSMG
SRRSFICRMRCGTSSHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQV
Sequence of entity 3 (E, G), FASTA
>5NJ8_3 DNA (5'-D(*GP*GP*TP*CP*AP*CP*GP*CP*AP*AP*CP*C)-3') (chains E, G)
GGTCACGCAACC
Sequence of entity 4 (F, H), FASTA
>5NJ8_4 DNA (5'-D(*GP*GP*TP*TP*GP*CP*GP*TP*GP*AP*CP*C)-3') (chains F, H)
GGTTGCGTGACC

Ligands and cofactors

IDNameFormulaCopies
ER3Erbium (III) ionEr12

Water and common crystallization additives (ACT) are not listed.

Primary citation

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation. Schulte, K.W., Green, E., Wilz, A. et al. Structure (2017) 25:1025-1033.e3. DOI 10.1016/j.str.2017.05.008 · PubMed

Other PDB entries of the same protein (UniProt P35869 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 5NJ8 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.