XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13605a. Determined by X-ray diffraction at 1.46 Å resolution. Released 13 May 2020.
Explore 5R4Z in 3D Show helices and sheets RCSB PDB PDBe
5R4Z contains 7 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 980-1001 | 22 | |
| α-helix | 1004-1009 | 6 | |
| α-helix | 1021-1024 | 4 | |
| α-helix | 1031-1039 | 9 | |
| α-helix | 1046-1063 | 18 | |
| α-helix | 1069-1092 | 24 | |
| α-helix | 1095-1107 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| ATPase family AAA domain-containing protein 2 | A | protein | 130 | Homo sapiens | Q6PL18 (AlphaFold model) |
>5R4Z_1 ATPase family AAA domain-containing protein 2 (chains A) SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYRTVIKEPMDLSSVISKI DLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFE QLCEEIQESR
| ID | Name | Formula | Copies |
|---|---|---|---|
| GWA | ~{N}-(3-acetamidophenyl)-2-methoxy-ethanamide | C11 H14 N2 O3 | 1 |
Water and common crystallization additives (EDO, SO4) are not listed.
XChem fragment screen. Talon, R., Krojer, T., Fairhead, M. et al. To be published.
Other PDB entries of the same protein (UniProt Q6PL18 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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