5SVY: MORC3 CW

MORC3 CW in complex with histone H3K4me1. Determined by X-ray diffraction at 1.05 Å resolution. Released 5 Oct 2016.

Method: X-ray diffraction
Resolution: 1.05 Å
Organism: Homo sapiens
Chains: 2
Atoms: 686
Mol. weight: 7.37 kDa
Ligands: ZN
Released: 5 Oct 2016

Explore 5SVY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5SVY contains 4 α-helices and 3 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	407	1
β-strand	408-412	5	1
β-strand	419-422	4	1
α-helix	435-437	3
α-helix	441-443	3
α-helix	449-454	6

Chain B: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	3-6	4	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MORC family CW-type zinc finger protein 3	A	protein	50	Homo sapiens	Q14149 (AlphaFold model)
H3K4me1	B	protein	11	Homo sapiens	P68431 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5SVY_1 MORC family CW-type zinc finger protein 3 (chains A)
SDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDE

Sequence of entity 2 (B), FASTA

>5SVY_2 H3K4me1 (chains B)
ARTKQTARKST

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Water and common crystallization additives (ACT) are not listed.

Primary citation

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Andrews, F.H., Tong, Q., Sullivan, K.D. et al. Cell Rep (2016) 16:3195-3207. DOI 10.1016/j.celrep.2016.08.050 · PubMed

Other PDB entries of the same protein (UniProt Q14149 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6O5W 1.41 Å, Crystal structure of MORC3 CW domain fused with viral influenza A NS1 peptide
5SVX 1.56 Å, MORC3 CW in complex with histone H3K4me3
5SVI 1.61 Å, MORC3 CW domain in complex with unmodified histone H3
4QQ4 1.75 Å, CW-type zinc finger of MORC3 in complex with the amino terminus of histone H3
6O1E 2.41 Å, The crystal structure of human MORC3 ATPase-CW in complex with AMPPNP

Browse structure collections

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